DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc6

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1372	Identity:	439/1372 - (31%)
Similarity:	691/1372 - (50%)	Gaps:	145/1372 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FKNEDLPEN--PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWA 66
            |..:..|.|  |...::..|...||:......||.:..||.|||:...:|:.:|.|.::|...|.
  Rat   199 FSEDSKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWR 263

  Fly    67 ---NELETNK-------------------KNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPM 109
               :||..:|                   :...|||.::|||...|:...|.|...:......|.
  Rat   264 RNFSELPGHKGHSGMGTPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPK 328

  Fly   110 FLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCL 174
             |:.|...|.....:|....:..|..:.|.:.|:.:....|.:.|..|.:::|..::.::|||.|
  Rat   329 -LLSLFLEFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKVL 392

  Fly   175 RLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFI 239
            .|:.......:.|.::||:|.|:.|:...|...:.|||..|..::....::|.:|.:|:..:...
  Rat   393 VLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAVF 457

  Fly   240 LLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINS 304
            |..:||..::.||.|..:.:...:...|.|:.:.::..::.||.:.||..|.:.:.|.|.:|:.:
  Rat   458 LSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELGA 522

  Fly   305 IRHVAYAKCLIWSFNRFLTPVSIFL-SLVGF-----VLMGRFLTAEVAFLITAYYNVVRTNMTAY 363
            ::..|:    ::|.:.....||.|| :||.|     |.....:.||.||:.....::: ....|:
  Rat   523 LKTSAF----LFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSIL-NKAQAF 582

  Fly   364 FSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPH 428
            ....|....:..||..|:...|..       |.|..||             :..:|.|.
  Rat   583 LPFSVHCLVQARVSFDRLAAFLCL-------EEVDPNG-------------MVLSPSRC------ 621

  Fly   429 NSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEI 493
            :|:|.:||......|:..||. .|.|:||.|..|.|:|:||..|:|||||:.|:||||....|.:
  Rat   622 SSKDRISIHNGTFAWSQESPP-CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSV 685

  Fly   494 EVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGAS 558
            .:.||::|..||.|:.:.:|.:|:.|.|.:|......|:..|||..|....|....|.:|::|.:
  Rat   686 SIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMN 750

  Fly   559 LSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQLQFL 621
            ||||||.|:||||:|||.|::||:||||:|:|:.|::.:|::.:  .|.|:....|||||.|..|
  Rat   751 LSGGQKQRLSLARAVYRRAAVYLMDDPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVL 815

  Fly   622 QQADQIVIMEMGKVKAVGTYES-LHKSGLDFGIVLD---DPVNDNEAAEDRSRTSSI-------- 674
            .|||||:::..|.:..:|:|:. ||::|...|: ||   .|..:.|.....:.||..
  Rat   816 PQADQILVLANGTIAEMGSYQDLLHRNGALVGL-LDGARQPAGEGEGEAHAAATSDDLGGFSGGG 879

  Fly   675 TDQRR---------SSVKSVLSHAESCP--EDV-------GEEQKINLQRQQLGRNGLGVYVDYF 721
            |..||         :.||...|.|:..|  :||       ||:.      .|.||.....|:.|.
  Rat   880 TPTRRPERPRPSDAAPVKGSTSEAQMEPSLDDVEVTGLTAGEDS------VQYGRVKSATYLSYL 938

  Fly   722 RAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLI 786
            ||.|..|. :..:..|:|.|..:....|:||.|        |.:...|.|    :||:|....:.
  Rat   939 RAVGTPLC-TYTLFLFLCQQVASFCQGYWLSLW--------ADDPVVDGK----QMHSALRGSIF 990

  Fly   787 TVLSIMVTIKRSFLFFNLA------MRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMG 845
            .:|..:..|.   ||.::|      .|||..|..|:...::|:.:.||.:.|.|::||||||:..
  Rat   991 GLLGCLQAIG---LFASMAAVFLGGARASCLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETD 1052

  Fly   846 QVDEMLPTIIMTVIQDFLLFG----GNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKR 906
            .||..:|..:.|::.  ..||    |  :.:::..||.::..|...::....:|.|:.|...::|
  Rat  1053 IVDVDIPDKMRTLLT--YAFGLLEVG--LAVSMATPLAIVAILPLMLLYAGFQSLYVATCCQLRR 1113

  Fly   907 LEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIF- 970
            ||:::.|.|.||.|.:..|...:|||.|.....|:.|...|.:...|:..:...|..|..:::.
  Rat  1114 LESASYSSVCSHLAETFQGSQVVRAFQAQGPFTAQHDALMDENQRISFPRLVADRWLAANLELLG 1178

  Fly   971 -CVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIE 1034
             .::|:| .|.:.......||...|.:::.|:.:|.|:||.||...:|||:|::|||:.:|....
  Rat  1179 NGLVFVA-ATCAVLSKAHLSAGLAGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYVHTP 1242

  Fly  1035 PEGP--LEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGA 1097
            .|.|  |.::|   ....||..|:|||.:..||:.|.|  ...::.:|..|...|||||||||||
  Rat  1243 KEAPWRLPSSA---AQPLWPCGGQIEFRDFGLRHRPEL--PMAVQGVSLKIHAGEKVGIVGRTGA 1302

  Fly  1098 GKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSD 1161
            |||||...|.|| ...:|.:.||.....|||||.|||:|:||||:||||.|::|.|||...|.:|
  Rat  1303 GKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQENTD 1367

  Fly  1162 DRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVD 1226
            :.:|.|||.|:||..|.|:...|:.:.:..|.:.||||:||:|||||:||..:||::|||||:||
  Rat  1368 EGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVD 1432

  Fly  1227 PQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDL 1291
            |.|:..:||.:...|.:||||.:||||.::|:..||||||.|:|.|.|:|.:||.  ....|..|
  Rat  1433 PGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARVLVMDEGQVAESGSPAQLLA--QKGLFYRL 1495

  Fly  1292 VKQTGQA 1298
            .:::|.|
  Rat  1496 AQESGLA 1502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	432/1345 (32%)
		ABC_membrane	94..360	CDD:294371	63/271 (23%)
		ABCC_MRP_domain1	434..634	CDD:213217	86/201 (43%)
		ABC_membrane	736..980	CDD:294371	68/255 (27%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	113/221 (51%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	437/1369 (32%)
		ABC_membrane	313..577	CDD:294371	63/269 (23%)
		ABCC_MRP_domain1	627..828	CDD:213217	86/201 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		12/54 (22%)
		ABC_membrane	950..1215	CDD:294371	74/284 (26%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	113/221 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345091
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650