DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc3

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001350116.1	Gene:	Abcc3 / 76408	MGIID:	1923658	Length:	1523	Species:	Mus musculus

Alignment Length:	1390	Identity:	486/1390 - (34%)
Similarity:	749/1390 - (53%)	Gaps:	158/1390 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FKNEDLPEN--PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW- 65
            |..|:|..|  |...:..||.||||:.....|.|.:..|..:||:...:|..:..:..:|..:|
Mouse   197 FSPENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQ 261

  Fly    66 -----ANELET-------------------NKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILT- 105
                 |:..:|                   ..|..|.||.|.|.|....    |:..|..:|..
Mouse   262 KQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSL----LMSACFNLIQNL 322

  Fly   106 ---VQPMFLMKLISSFSNP-SPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVS 166
               |.|..|..||...|:| :||..|  :..||.:.|.|.::.::::.|...:..:.|::|..:.
Mouse   323 LGFVNPQLLSILIRFISDPTAPTWWG--FLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAII 385

  Fly   167 SMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIA 231
            .:||||.|.:|.:...|.:.|.::||:|.|..|......|.:.||.||||.::..|.::|.:|.:
Mouse   386 GVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPS 450

  Fly   232 AVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAH 296
            |:.|:..|:|.|||...:..|:...::|.....|.|:::|:||:.||:|:|:||||..|.:.|..
Mouse   451 ALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKG 515

  Fly   297 ARHKEINSIRHVAYAKCL---IWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVR- 357
            .|..|:..:|..||.:.:   ||....||..: |.|.:..:|.....|.||.||:..:.:|:::
Mouse   516 IRQSELQLLRKGAYLQAISTFIWICTPFLVTL-ITLGVYVYVDESNVLDAEKAFVSLSLFNILKI 579

  Fly   358 -TNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMR 421
             .||......|:||.:   ||:||:|..|              |..|.|.|....|   |.:|..
Mouse   580 PLNMLPQLISGLTQAS---VSLKRIQDFL--------------NQNELDPQCVERK---TISPGY 624

  Fly   422 APEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGEL 486
            |           ::|......|..:.|. ||..:|:|:..|||||:||..|.|||||:.|:|||:
Mouse   625 A-----------ITIHNGTFTWAQDLPP-TLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEM 677

  Fly   487 RVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTI 551
            ....|.:.|.||::|..|:.|:.:.|:::|:||||||:.:||...:..|||..|.::||..|:|.
Mouse   678 EKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTE 742

  Fly   552 LGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILV 614
            :|::|.:|||||:.|:||||:||.||:|:|||||||||||.||:.:|::.:  .|.|..|..:||
Mouse   743 IGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLV 807

  Fly   615 THQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVL-----DDPVNDNEAA--------- 665
            ||.:.||.|.|.|:::..|:|..:|.|.:|.:....|...|     |:...|:|||
Mouse   808 THGISFLPQTDFIIVLAGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVL 872

  Fly   666 --EDRSRT-SSITD----------QRRSSVKSVLSHAESCPEDVGEEQKINLQRQQL-------- 709
              ||...| :.:||          |....:.|:.|..|.....:.::...:|:::.|
Mouse   873 LLEDTLSTHTDLTDNEPAIYEVRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETG 937

  Fly   710 ----------GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLG-DYFLSPWVSRNEKMVA 763
                      |...|.||.||.::.|...:.|:.:.:  ..|..|::| :.:||.|.:..|:...
Mouse   938 ALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLY--GGQSAAAIGANVWLSAWSNDAEEHGQ 1000

  Fly   764 HNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFF 828
            .|.|:....         :|..:.:|..::.:..:|.....|::|:..||.::.....|:...||
Mouse  1001 QNKTSVRLG---------VYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFF 1056

  Fly   829 NKNPAGSILNRFSKDMGQVDEML-PTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYY 892
            :..|:|.||||||||:..:||:| |||:| ::..|......|:||....|||::..|...::..:
Mouse  1057 DTTPSGRILNRFSKDIYVIDEVLAPTILM-LLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGF 1120

  Fly   893 LRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFI 957
            ::.||:.||..:||||:.:|||::|||:.::.|.|.|||:|.....:...|...|.:..:||.:|
Mouse  1121 VQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYI 1185

  Fly   958 STSRAFAYWMDIF------CVLFIAMITLSFFIFPPSSAAD--VGLAITQAMGLTGTVQWTVRQS 1014
            :::|    |:.:.      ||:..|.:   |.:...:|...  |||:::.|:.:|..:.|.:|..
Mouse  1186 ASNR----WLGVHVEFVGNCVVLFAAL---FAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMI 1243

  Fly  1015 AELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSL 1079
            ::||:.:|:|||:.||.:.:.|.|....:::.| |.||.:|.:||...|:||.|.|  |.|||::
Mouse  1244 SDLESNIIAVERVKEYSKTKTEAPWVVESNRAP-EGWPTRGMVEFRNYSVRYRPGL--ELVLKNV 1305

  Fly  1080 SFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPV 1143
            :..::..|||||||||||||||:...||| |...:|.:.||..:...:|||||||:::||||:|:
Mouse  1306 TVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPI 1370

  Fly  1144 LFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARA 1208
            |||||:|.|||||..||::.:|.|||...|...|:|...||:.:..|||.|.|||||||||||||
Mouse  1371 LFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARA 1435

  Fly  1209 ILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEF 1273
            :||.:|:||:|||||.:|.:||.|||.|||.:|.:|||||:||||:||||.:||||:|.|.|.||
Mouse  1436 LLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEF 1500

  Fly  1274 GTPYELLTADDTNAFQDLVKQTGQA 1298
            .:|..|:.|.  ..|..:.|..|.|
Mouse  1501 DSPVNLIAAG--GIFYGMAKDAGLA 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	478/1363 (35%)
		ABC_membrane	94..360	CDD:294371	85/275 (31%)
		ABCC_MRP_domain1	434..634	CDD:213217	92/201 (46%)
		ABC_membrane	736..980	CDD:294371	74/251 (29%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	127/221 (57%)
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	484/1387 (35%)
Abcc3	NP_001350116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..923		3/19 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841635
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660