DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31792 and ABCC8

DIOPT Version :9

Sequence 1:NP_001260548.1 Gene:CG31792 / 35163 FlyBaseID:FBgn0051792 Length:1323 Species:Drosophila melanogaster
Sequence 2:XP_016873686.1 Gene:ABCC8 / 6833 HGNCID:59 Length:1604 Species:Homo sapiens


Alignment Length:1411 Identity:434/1411 - (30%)
Similarity:716/1411 - (50%) Gaps:167/1411 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 NIFSALSFWYTIPTFIK-GQKVTLGAKDLYRALKEHRAESLGNKLCSSW----ANELETNKKNAS 77
            |:.|..::|: :..||| ..|..:..:.:.:.....||.:...:||.::    ..:::..:...:
Human   223 NLLSKGTYWW-MNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARA 286

  Fly    78 LLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFS------NPSPTSNGV-------- 128
            :.:.|...|||..|.........:::....|:.:..::....      .|.....||        
Human   287 IWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEF 351

  Fly   129 -AYAYAGGVILGSAL---KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDL--GEISTG 187
             |.||...|:|..||   :..|...|..|: ..|:.:|..:.:.||.|.:.|:.::|  ||::.|
Human   352 LANAYVLAVLLFLALLLQRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAG 415

  Fly   188 HIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKK 252
            .|.||::.|..::..|......||..|:|.::...|:|..:|::|:.|...|:|..|:|.::..|
Human   416 QICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480

  Fly   253 ISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWS 317
            :|..:..|...|::|::...|::.||:::|:||||..|...|...|.||:.|:|..|....:...
Human   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIF 545

  Fly   318 FNRFLTPVSIFLSLVGFVLMGRFLTAE----VAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSI 378
            .|..:...::.::.||.|..  |..|:    |||...:.::::.|.:....|| |..|.:.|||:
Human   546 MNTAIPIAAVLITFVGHVSF--FKEADFSPSVAFASLSLFHILVTPLFLLSSV-VRSTVKALVSV 607

  Fly   379 KRVQKLLLSGEVVAKDENVVSN-----GAEEDLQEAREKLLVT-------------PTPMRAPEK 425
            :::.:.|.|.|:  ::|....:     |.....|...|.|...             |.|:|...:
Human   608 QKLSEFLSSAEI--REEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNR 670

  Fly   426 PPHNSEDCVSIS-------------------ELKAKWTTNSPD--YTLSGVNLQVHAGALVAIVG 469
            .....|||..::                   ::...:.|.:||  .|||.:.:::..|.|..|||
Human   671 KRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVG 735

  Fly   470 HTGSGKSSLIQAILGELRVESG---------------------------EIEVTGSMSYASQEPW 507
            ..|.|||||:.|.|||::..||                           :|...|.::||||:||
Human   736 QVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPW 800

  Fly   508 LFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARS 572
            |.:.||.:||:|..|.:::||.:|:..|:|:.|.::||..|:|.:|:||.:|||||:.|||:||:
Human   801 LLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARA 865

  Fly   573 VYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKV 635
            :|:.|::..||||.||:|..::..|.:..:...|||  :.|:||||:||:|..||.|:.|:.|.:
Human   866 LYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI 930

  Fly   636 KAVGTYESLHKSGLDFG------IVLDDPVNDNEAAEDRSRTSSITDQRR--SSVKSVLSHAESC 692
            :..||.:...:|.....      :...|...:.|...:|..|.......|  ||...:|...|..
Human   931 QREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEE 995

  Fly   693 PEDVGE-EQKINL-----QRQQLGRNGLGVYVDYFRAGGGFLSFS--VVMTFFVCSQGLASLG-- 747
            .|:..| |:..||     ||.::.          :||...:||.:  ::::..|.||.|..:.  
Human   996 EEEAAESEEDDNLSSMLHQRAEIP----------WRACAKYLSSAGILLLSLLVFSQLLKHMVLV 1050

  Fly   748 --DYFLSPWVSRNEKMVAHNYTTDAKDADFEMHA-------AYIYMLITVLSIMVTIKRSFLFFN 803
              ||:|:.|...     |...|..|::.......       |.::.::..|.|::.:..|.....
Human  1051 AIDYWLAKWTDS-----ALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEW 1110

  Fly   804 LAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGN 868
            ..::.:.:||.|:...|..|.|.||...|.||||||||.|...:|:.:|:.:..:.:..||....
Human  1111 TGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSA 1175

  Fly   869 IIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFG 933
            :.||:.|.|:||:..|...||.|:::.::...|.|:::|:.:|:.|:.||||.::.||:|||||.
Human  1176 LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFR 1240

  Fly   934 AGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI------FCVLFIAMIT-LSFFIFPPSSAA 991
            ..:..:.:...|.|.::.||....:.:|    |:::      .||:.||.:| :|..:....||.
Human  1241 YEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMEYIGACVVLIAAVTSISNSLHRELSAG 1301

  Fly   992 DVGLAITQAMGLTGTVQWTVRQSAELENTMISVER---MIEYEEIEPEGPLEATADKKPHESWPE 1053
            .|||.:|.|:.::..:.|.||..|::|..:.:|:|   :::.|....||.|..:...|   :||:
Human  1302 LVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPK---NWPD 1363

  Fly  1054 QGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVR 1117
            ||||:...||:||:..||  .|||.::.:|.|.:|:||.||||:||||...|.||: ...:|.:.
Human  1364 QGKIQIQNLSVRYDSSLK--PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHII 1426

  Fly  1118 IDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVAT 1182
            ||..|...:.||.|||::|||.|:|||||||:|.||||..:.||..||.|||..:||.||.::..
Human  1427 IDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPG 1491

  Fly  1183 GLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVL 1247
            ||:..|||||.|||.|||||.|||||.:|...|.:||||||::|..|:.::|..:...|.:.||:
Human  1492 GLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVV 1556

  Fly  1248 TVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVK 1293
            |:|||:|||:.:|.|:|:..|.::||..|.:||:..| :.|...|:
Human  1557 TIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKD-SVFASFVR 1601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31792NP_001260548.1 CFTR_protein 12..1281 CDD:273530 430/1397 (31%)
ABC_membrane 94..360 CDD:294371 73/289 (25%)
ABCC_MRP_domain1 434..634 CDD:213217 86/249 (35%)
ABC_membrane 736..980 CDD:294371 74/261 (28%)
ABCC_MRP_domain2 1055..1276 CDD:213211 111/221 (50%)
ABCC8XP_016873686.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151567
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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