Protein Alignment CG31792 and ABCC8

DIOPT Version :10

• Sequence 1: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_001338224.1
• Gene: ABCC8 / 6833
• HGNCID: 59
• Length: 1603
• Species: Homo sapiens
• Alignment Length: 1410
• Identity: 434/1410 - (30%)
• Similarity: 716/1410 - (50%)
• Gaps: 166/1410 - (11%)

  Fly    18 NIFSALSFWYTIPTFIK-GQKVTLGAKDLYRALKEHRAESLGNKLCSSW----ANELETNKKNAS 77
            |:.|..::|: :..||| ..|..:..:.:.:.....||.:...:||.::    ..:::..:...:
Human   223 NLLSKGTYWW-MNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGARA 286

  Fly    78 LLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFS------NPSPTSNGV-------- 128
            :.:.|...|||..|.........:::....|:.:..::....      .|.....||
Human   287 IWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEF 351

  Fly   129 -AYAYAGGVILGSAL---KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDL--GEISTG 187
             |.||...|:|..||   :..|...|..|: ..|:.:|..:.:.||.|.:.|:.::|  ||::.|
Human   352 LANAYVLAVLLFLALLLQRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAG 415

  Fly   188 HIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKK 252
            .|.||::.|..::..|......||..|:|.::...|:|..:|::|:.|...|:|..|:|.::..|
Human   416 QICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480

  Fly   253 ISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWS 317
            :|..:..|...|::|::...|::.||:::|:||||..|...|...|.||:.|:|..|....:...
Human   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIF 545

  Fly   318 FNRFLTPVSIFLSLVGFVLMGRFLTAE----VAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSI 378
            .|..:...::.::.||.|..  |..|:    |||...:.::::.|.:....|| |..|.:.|||:
Human   546 MNTAIPIAAVLITFVGHVSF--FKEADFSPSVAFASLSLFHILVTPLFLLSSV-VRSTVKALVSV 607

  Fly   379 KRVQKLLLSGEVVAKDENVVSN-----GAEEDLQEAREKLLVT-------------PTPMRAPEK 425
            :::.:.|.|.|:  ::|....:     |.....|...|.|...             |.|:|...:
Human   608 QKLSEFLSSAEI--REEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNR 670

  Fly   426 PPHNSEDCVSIS-------------------ELKAKWTTNSPD--YTLSGVNLQVHAGALVAIVG 469
            .....|||..::                   ::...:.|.:||  .|||.:.:::..|.|..|||
Human   671 KRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVG 735

  Fly   470 HTGSGKSSLIQAILGELRVESG--------------------------EIEVTGSMSYASQEPWL 508
            ..|.|||||:.|.|||::..||                          :|...|.::||||:|||
Human   736 QVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWL 800

  Fly   509 FSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSV 573
            .:.||.:||:|..|.:::||.:|:..|:|:.|.::||..|:|.:|:||.:|||||:.|||:||::
Human   801 LNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARAL 865

  Fly   574 YRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKVK 636
            |:.|::..||||.||:|..::..|.:..:...|||  :.|:||||:||:|..||.|:.|:.|.::
Human   866 YQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQ 930

  Fly   637 AVGTYESLHKSGLDFG------IVLDDPVNDNEAAEDRSRTSSITDQRR--SSVKSVLSHAESCP 693
            ..||.:...:|.....      :...|...:.|...:|..|.......|  ||...:|...|...
Human   931 REGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEE 995

  Fly   694 EDVGE-EQKINL-----QRQQLGRNGLGVYVDYFRAGGGFLSFS--VVMTFFVCSQGLASLG--- 747
            |:..| |:..||     ||.::.          :||...:||.:  ::::..|.||.|..:.
Human   996 EEAAESEEDDNLSSMLHQRAEIP----------WRACAKYLSSAGILLLSLLVFSQLLKHMVLVA 1050

  Fly   748 -DYFLSPWVSRNEKMVAHNYTTDAKDADFEMHA-------AYIYMLITVLSIMVTIKRSFLFFNL 804
             ||:|:.|...     |...|..|::.......       |.::.::..|.|::.:..|......
Human  1051 IDYWLAKWTDS-----ALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWT 1110

  Fly   805 AMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNI 869
            .::.:.:||.|:...|..|.|.||...|.||||||||.|...:|:.:|:.:..:.:..||....:
Human  1111 GLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSAL 1175

  Fly   870 IVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGA 934
            .||:.|.|:||:..|...||.|:::.::...|.|:::|:.:|:.|:.||||.::.||:|||||..
Human  1176 AVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRY 1240

  Fly   935 GSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI------FCVLFIAMIT-LSFFIFPPSSAAD 992
            .:..:.:...|.|.::.||....:.:|    |:::      .||:.||.:| :|..:....||..
Human  1241 EARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMEYIGACVVLIAAVTSISNSLHRELSAGL 1301

  Fly   993 VGLAITQAMGLTGTVQWTVRQSAELENTMISVER---MIEYEEIEPEGPLEATADKKPHESWPEQ 1054
            |||.:|.|:.::..:.|.||..|::|..:.:|:|   :::.|....||.|..:...|   :||:|
Human  1302 VGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPK---NWPDQ 1363

  Fly  1055 GKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRI 1118
            |||:...||:||:..||  .|||.::.:|.|.:|:||.||||:||||...|.||: ...:|.:.|
Human  1364 GKIQIQNLSVRYDSSLK--PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIII 1426

  Fly  1119 DDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATG 1183
            |..|...:.||.|||::|||.|:|||||||:|.||||..:.||..||.|||..:||.||.::..|
Human  1427 DGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGG 1491

  Fly  1184 LETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLT 1248
            |:..|||||.|||.|||||.|||||.:|...|.:||||||::|..|:.::|..:...|.:.||:|
Human  1492 LDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVT 1556

  Fly  1249 VAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVK 1293
            :|||:|||:.:|.|:|:..|.::||..|.:||:..| :.|...|:
Human  1557 IAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKD-SVFASFVR 1600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	434/1410 (31%)
ABCC8	NP_001338224.1	MRP_assoc_pro	224..1600	CDD:188098	432/1407 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1009		14/51 (27%)