DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc12

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_009301629.1	Gene:	abcc12 / 568482	ZFINID:	ZDB-GENE-050517-25	Length:	1368	Species:	Danio rerio

Alignment Length:	1351	Identity:	448/1351 - (33%)
Similarity:	733/1351 - (54%)	Gaps:	117/1351 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESL-GNKLCSSWANEL-ETNKK 74
            :|.:.:..||..||.:..|...:..:..|....|:  |..|....: |.:....|..|: ....:
Zfish    67 HPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF--LSPHDGAHINGERFQRLWDEEVARVGLE 129

  Fly    75 NASLLRVLFRVFGRYFV--FLGLVLFCLEVILTVQPMFLMKLISSF---SNPSPTSNGVAYAYAG 134
            .|||..|:.|.....|:  ||..|:|...|.  |.|..|:..|.::   |.||...:||....|
Zfish   130 KASLSAVIMRFQKTRFIVSFLASVMFAFAVF--VGPSILVYEILNYVEQSEPSTVVHGVGVCVA- 191

  Fly   135 GVILGSALKVILMNPYSFA-------VTHLGLKIRV-GVSSMI-YRKCLRLTKTDLGEISTGHII 190
                      :.:..:|.|       ..:|...:|| |..||: ::|.:.|  ..|..|:.|..|
Zfish   192 ----------LFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISL--RSLTTITVGETI 244

  Fly   191 NLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQ--EIGIAAVFGMTFILLFIPLQMYLGKKI 253
            |::::|..|:...:.|..:|...|:  |::..::|.  .:|..|:.|:...|:|:|:|..:.:.|
Zfish   245 NVLTSDGYRLFDAVIFGTFLLCVPV--LLIICIIYACFILGYTALIGILVYLIFLPIQFSIARLI 307

  Fly   254 SGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSF 318
            ...|.:....:|||:|.|.|::..|::|||||||..|||.:...|..|...::...|    :.|.
Zfish   308 GVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGY----VQSL 368

  Fly   319 NRFLTP-VSIFLSLVGFVLMGRF---LTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIK 379
            |..||. |....::|.|::....   |....|:.|.|.:|.:|.:| ......|...||..|::.
Zfish   369 NSSLTTIVPTLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSM-GLLPFSVKAVAEAKVALT 432

  Fly   380 RVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTP------MRAPEKPPHNSEDCVSISE 438
            |:::::|    |...:..::.....||....||...:.:|      .:.||.|..|.:.
Zfish   433 RLKRIML----VQNPKGYLTQDKNMDLALVMEKATFSWSPTDDKNTSQMPENPSQNGKH------ 487

  Fly   439 LKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYAS 503
             ||:   :.|  :|..::|.:..|:|:.:.|:.||||:|||.:||.::.:.||.:...|:::|.|
Zfish   488 -KAE---SQP--SLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGTLAYVS 546

  Fly   504 QEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARIS 568
            |:.|:|.||||.|||.|:|.|..||..|:..|.|:.|..:||..|:|.:|:||.:||||||.|:|
Zfish   547 QQAWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVS 611

  Fly   569 LARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMG 633
            |||:||.:..|:||||||||||:.|.:.:||||::..|:.|.|||||||||:|:..|::::::.|
Zfish   612 LARAVYSNRDIFLLDDPLSAVDAHVGKHIFEECIKKELKGKSVILVTHQLQYLEFCDEVMLLDNG 676

  Fly   634 KVKAVGTYESLHK-----SGLDFGIVLDDPVNDNEAAEDRSRT----SSITDQRRSSVKSVLSHA 689
            ::|..||:..|.|     |.|...:.|:   .:||.|:.:.:|    |..|:........:.:.|
Zfish   677 EIKEAGTHSDLMKTKGRYSQLITNVHLE---QNNERADSKPQTEHNDSEQTNPDEPKANGIENPA 738

  Fly   690 ----------ESCPEDVGE-----EQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVC 739
                      ...|:|..|     :|.:..:..|.|......|..|.:|.||::...:|:..|..
Zfish   739 FDMSDEKPATNETPKDSSETKGKKDQLVTREVAQEGSVTWRTYHQYCQAAGGYILLFLVVLLFTL 803

  Fly   740 SQGLASLGDYFLSPWVSRNEKMVAHNYTTDA--------KDADFEMHAAYIYMLITVLSIMVTIK 796
            ..|..:..:::||.|:.:..   .:|.:::|        ::.|...: ..:|.:|.:..|:::|.
Zfish   804 LVGSTAFSNWWLSYWLDQGS---GNNSSSNATSNSGNISENPDLSFY-QMVYGVIIIAMIVLSIL 864

  Fly   797 RSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQD 861
            :.:.|..:.:|:|.:||::||:.|..:.|.||:..|.|.::||||||..:||.:||..:...:|.
Zfish   865 KGYTFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQF 929

  Fly   862 FLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGL 926
            .|:....::.|.||.|..||..:..|::...:...:.::...:||:|..:|||..|...:::.||
Zfish   930 CLIVTFTLLTICIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGL 994

  Fly   927 STIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAA 991
            |||.|:.........|....|.:|:...:|.:.:|..::|:|:.......:::| |.:..|:...
Zfish   995 STIHAYDKRQQYIERFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSL-FVVLSPNETI 1058

  Fly   992 D---VGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEY-EEIEPEGPLEATADKKPHESWP 1052
            :   .|||::..:.|||.:|:.||.|.|:|....||||::|| .....||| ....|......||
Zfish  1059 NPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGP-RRVKDANIPAGWP 1122

  Fly  1053 EQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSY-NDGSV 1116
            ::|.|.|...|:||..  .:..||.:|:..|:|.||:|||||||:|||||..|||||:. .:|::
Zfish  1123 QEGTITFKNYSMRYRD--NTPIVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTI 1185

  Fly  1117 RIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVA 1181
            .|||.|...:||.||||::|:|||:||||.||||:|||||:.|.|:.||.|||:..:||.::.:.
Zfish  1186 LIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLP 1250

  Fly  1182 TGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTV 1246
            ..|::.:.|.|.|||||:|||:|:|||:||:::|:::|||||::|.:||:|||.|||:.|:.||:
Zfish  1251 EKLQSPVVENGENFSVGERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTM 1315

  Fly  1247 LTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQ 1297
            ||:|||::|:::|||:||||.|:|:||..|.:|:...: :.|..|:....|
Zfish  1316 LTIAHRINTVLESDRILVMDQGKVIEFDPPQDLIQRPN-SLFASLLAAANQ 1365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	445/1333 (33%)
		ABC_membrane	94..360	CDD:294371	77/283 (27%)
		ABCC_MRP_domain1	434..634	CDD:213217	90/199 (45%)
		ABC_membrane	736..980	CDD:294371	64/251 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	119/221 (54%)
abcc12	XP_009301629.1	CFTR_protein	68..1366	CDD:273530	448/1350 (33%)
		ABC_membrane	149..414	CDD:294371	79/285 (28%)
		ABCC_MRP_domain1	457..677	CDD:213217	97/231 (42%)
		ABC_membrane	809..1077	CDD:294371	71/272 (26%)
		ABCC_MRP_domain2	1125..1345	CDD:213211	119/221 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586090
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660