DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc9

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_005164758.1	Gene:	abcc9 / 561160	ZFINID:	ZDB-GENE-050517-23	Length:	1583	Species:	Danio rerio

Alignment Length:	1397	Identity:	424/1397 - (30%)
Similarity:	712/1397 - (50%)	Gaps:	175/1397 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFIKGQK------------VTLGAKDLYRALKEHRAESLGNKLCSSWANELE 70
            |:.|..::|:..|..|...|            :.:.|...|..||:...|...|         .|
Zfish   223 NLLSKATYWWMNPLIIGAHKRPIELKKIGKLPIAMRALTNYLRLKDSYEEQRQN---------TE 278

  Fly    71 TNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSN------PSPTSN--- 126
            ..:|:.|:.:.::|.||...:......:..:::....|:.:..::....|      .:.|.|
Zfish   279 DPEKSPSIWKSMYRAFGGSILLSSTFRYMADLLGFAGPLCISGIVEHLHNSTEIDRTNKTGNMTF 343

  Fly   127 GVAYAYAGGVILGSA-------LKVILMNPY---SFAVT-HLGLKIRVGVSSMIYRKCLRLTKTD 180
            ||.:..:..::..::       |.::|...:   |:.|| ..|:.:|..:.:|||.|.|||:.::
Zfish   344 GVYFMSSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSN 408

  Fly   181 --LGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFI 243
              :||::.|.|.||::.:..::..|:.....||..|:|.:|...|:|..:|.:|:.|...|||..
Zfish   409 MSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLLA 473

  Fly   244 PLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHV 308
            |:|..:..|::.::..|...|..|::..|||:.||:::|:||||..|...|...|.||:.|::..
Zfish   474 PVQYLIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELTSLKTF 538

  Fly   309 AYAKCLIWSFNRFLTPVSIFLS--------LVGFVLMGRF----LTAEVAFLITAYYNVVRTNMT 361
            |           ..|.:|||::        |..||.....    |:...||...|.::::.|.:.
Zfish   539 A-----------LHTSMSIFMNAAIPIAAVLATFVTHAYIEEDRLSPAKAFASLALFHILVTPLF 592

  Fly   362 AYFSVGVTQTAETLVSIKRVQKLLLSGEV---------------VAK------DENVVSNGAEED 405
            ...:| |....:.|||::::.:.|.|.|:               |.|      |...::
Zfish   593 LLSTV-VRFAVKALVSVQKLSEFLQSDEIGDDSWRNGDMCMSLEVGKKYKYQGDTKAIN------ 650

  Fly   406 LQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGH 470
             ::.|.::.....|:|...:|....:..|.:::....|.:|..  |||.:|:::..|.|..|||.
Zfish   651 -RKGRYRMDNYEQPVRRQLRPSETEDVAVQVNDGFFTWGSNLS--TLSDINIRIPTGQLTMIVGQ 712

  Fly   471 TGSGKSSLIQAILGELRVESGEI--------------EVTG---------------SMSYASQEP 506
            .|.|||||:.|:|||::..||::              .::|               |::||:|:.
Zfish   713 VGCGKSSLLLAMLGEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYATQKS 777

  Fly   507 WLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLAR 571
            ||.:.||.:||.||.|.:::||..|:..|:|:.|.:|||..|:|.:|:||.:|||||:.||.:||
Zfish   778 WLLNATVEENITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVAR 842

  Fly   572 SVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGK 634
            ::|::.:|..||||.||:|..::..|.:|.:...|:|  :.|:||||:||:|..||.|:.|:.|.
Zfish   843 ALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGS 907

  Fly   635 VKAVGTYESLHKSGLDFGIVLDDPVN--DNEAAEDRSRTSSITDQRRSSVKSVLSHA-------E 690
            |...||.:.:....::........:|  |.|..:|....|..|.:|::..::..|..       |
Zfish   908 VLREGTLKDIQTHDVELYEHWKTLMNRQDQELEKDTDLESQTTLERKTLRRAFYSREAKNHVDDE 972

  Fly   691 SCPEDVGEEQKINL-----QRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLG--- 747
            ...|:|.||...|:     :|.::.......|:    :.||||     |.|.:.|..||...
Zfish   973 DEEEEVEEEDDDNMSTTTSRRSKIPWKMCCCYL----SSGGFL-----MVFLMVSSKLAKHSVMV 1028

  Fly   748 --DYFLSPWVS---RNEKMV--AHNYTTDAKDADFEMHAAY--IYMLITVLSIMVTIKRSFLFFN 803
              ||:|:.|.|   .|:..|  :.|:|.:........|.:|  :::::...:|.:.:..|.....
Zfish  1029 AIDYWLAAWTSSNPHNQSFVNSSFNHTLNDDATQIAEHRSYVPVFIILCAAAIALCLITSLTVEF 1093

  Fly   804 LAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGN 868
            |.:.|:..||:::...|..|.:.||:..|.|.||||||.|...:|:.:|..:.::.:..||....
Zfish  1094 LGVAAATNLHHNLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCLSA 1158

  Fly   869 IIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFG 933
            |.|||.|.|.|||..:...:..|:::.::...|.|::.|:.||:.|:..||:.:..||:|||||.
Zfish  1159 IGVIAFVTPAFLIALVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFR 1223

  Fly   934 AGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLS---FFIFPPSSAADVGL 995
            ..:..:.......|.:::| |:|:|.:..   |:::......|:|.|:   ..|:..|.:..|||
Zfish  1224 HEARFKQRMLELTDTNNTA-YLFLSAANR---WLEVRTDYLGAVIVLTAAVAAIWSTSPSGLVGL 1284

  Fly   996 AITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATAD-KKPHESWPEQGKIEF 1059
            .:|.|:.||..:.|.||..|:||..|.:|:::..:...|.|. .|.:.| .:..|.||:.|:|..
Zfish  1285 GLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESEN-YEGSMDVSQVPEDWPQHGEITI 1348

  Fly  1060 VELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDT 1123
            .:|.:||:..||  .|||.::..|.|.:||||.||||:|||||..|.|.: ...:|.:.||..|.
Zfish  1349 HDLCVRYDSMLK--PVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVIDGIDI 1411

  Fly  1124 NDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKI 1188
            ..:.|..|||::|||.|:||||||::|.||||....:|||||.|||..:||::|.::..||:..:
Zfish  1412 CKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGGLDAVV 1476

  Fly  1189 TEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRL 1253
            ||||.|||||||||.|||||.:|.:.||:||||||::|..|:.::|..:...|.:.||:|:||.:
Zfish  1477 TEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHLV 1541

  Fly  1254 HTIMDSDRVLVMDAGRVVEFGTPYELLTADDT 1285
            .:|:::::|||..:|.:||..:...||..:|:
Zfish  1542 SSILEAEQVLVFSSGILVENDSAINLLAQEDS 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	422/1391 (30%)
		ABC_membrane	94..360	CDD:294371	75/299 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	86/230 (37%)
		ABC_membrane	736..980	CDD:294371	71/255 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	106/221 (48%)
abcc9	XP_005164758.1	CFTR_protein	223..1575	CDD:273530	424/1397 (30%)
		ABC_membrane	304..591	CDD:294371	75/297 (25%)
		ABCC_SUR1_N	678..907	CDD:213257	86/230 (37%)
		ABC_membrane	1045..1300	CDD:294371	72/258 (28%)
		ABCC_SUR2	1269..1583	CDD:213255	133/308 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585997
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650