DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG31792 and cftr

DIOPT Version :10

Sequence 1:NP_724148.2 Gene:CG31792 / 35163 FlyBaseID:FBgn0051792 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_001038348.1 Gene:cftr / 559080 ZFINID:ZDB-GENE-050517-20 Length:1485 Species:Danio rerio


Alignment Length:1504 Identity:425/1504 - (28%)
Similarity:718/1504 - (47%) Gaps:226/1504 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNK 73
            :..:|.|.:|..|...||:|.|...||.|..|...|:|:|..:..|:.|..:|...|..|:.:.|
Zfish     1 MQRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGK 65

  Fly    74 KNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSF--SNPSPTSNGVAYAYAGGV 136
            |..||||.:.|.:.:.|:..|.:|:..|...||||..|.::|:||  ::....:||...|:..|:
Zfish    66 KKPSLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFDPAHEPERANGYFLAFGLGL 130

  Fly   137 ILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMD 201
            :.  ..:.:|:.|..|.:.|||::||:.:.|:||:|.|:|:...|.:||||.:::|:|.:||:.|
Zfish   131 LF--TARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFD 193

  Fly   202 TFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDK 266
            ..:...|::|::|||.::.|.|:::.|.:.:...:..|.|...||.:|..|:...:.:..:.::|
Zfish   194 QSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAFLSHKMGPYKAQKVLLTNK 258

  Fly   267 RMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFLSL 331
            |:.:.:||:..:..:|.|.||...|.::.:.|..|:...|.:...: ..:|...|.:.:.:.::.
Zfish   259 RLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLR-YFYSSAYFFSAIFVIVAA 322

  Fly   332 VGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE--VVAKD 394
            |....:.|.:.....|...:|..|:|..:|......:....:|:..|.::::.|...|  ::..|
Zfish   323 VVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQMWYDTMRLIWKIEEFLSKEEYKLMEYD 387

  Fly   395 ENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPP------HNSEDCVSISELKAKWTTNSPDYTLS 453
            .::    .|.:||:........|..:....|..      ||.:..:..:.|..     :|  .|.
Zfish   388 LSI----TELELQDVTASWDEGPGELLERIKQENKANGHHNGDAGLFFTNLYV-----AP--VLK 441

  Fly   454 GVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNIL 518
            .::|::..|.::|:.|..|||||||:..|||||...||:|..:|.:||:||..|:..||:|.|||
Zfish   442 DISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISYSSQTAWIMPGTIRDNIL 506

  Fly   519 FGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLD 583
            ||...|..||..||:.|.||.|...||.||||.:.:.|.:||||||||::|||:|||||.:||||
Zfish   507 FGLTYDEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALARAVYRDADLYLLD 571

  Fly   584 DPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSG 648
            .|.:.:|.:..:.:|::||...:..|..||||::::.|::||:|:::..|:....||:..|....
Zfish   572 APFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESFFYGTFPELQSER 636

  Fly   649 LDF-GIVLDDPVNDNEAAEDR--------------------------------------SRTSSI 674
            .|| .::|.....||.:||.|                                      .|.:|:
Zfish   637 PDFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQPERSAFRQVPPTKPMYIDERKASV 701

  Fly   675 --------------------------------------------------------TDQRRSSVK 683
                                                                    ..|||.||.
Zfish   702 IVNPLGVARKASFIQVPEEEVRRTLPDRKFSLVPENELVDESFMGSDVYHNHGVHMAGQRRQSVL 766

  Fly   684 SVLSHAESCPEDVGEEQKINLQ---RQQLG------------------------RNGL------- 714
            :.:::|:      |:.::.:||   |::|.                        ..|:       
Zfish   767 AFMTNAQ------GQGRREHLQSSFRRRLSVVPQSELASELDIYTRRLSDSTYDMTGILEEENIE 825

  Fly   715 -------------------GVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFL---SPWVSR 757
                               ..||.|.......|...:.:.|....:...|:...||   ..|...
Zfish   826 ACLTDEIDEIEETFETTKWNTYVRYVSNNKSLLYVLIFILFIAAIEIAGSVAGIFLITDELWREE 890

  Fly   758 NEK----MVAHNYTTDAKDA-------DFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQ 811
            :::    |..|:..:.:...       ....:..|||:..:...:.:...|...|.:..:..|.:
Zfish   891 HQRSEPNMTKHSNASSSGQTYAITVTPTSSYYILYIYVATSESLLAMGFFRGLPFVHTTITISKK 955

  Fly   812 LHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVN 876
            ||..|...:..|.|...|....|.|:|||:|||..:|:|||.::...:|..::..|.|:|::||.
Zfish   956 LHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGCILVVSIVR 1020

  Fly   877 PLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAE 941
            |...:.|....|:...:|.::|:|...:|:||...|||::||...||.||.|||||...:..||.
Zfish  1021 PYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLKGLWTIRAFERQAYFEAL 1085

  Fly   942 FDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSS---AADVGLAITQAMGL 1003
            |....:.|::..::::||.|.|.:..||   ||:...||:.:|...::   ..::|:.|..||.:
Zfish  1086 FHKTLNTHTATWFLYLSTLRWFLFRADI---LFVFFFTLAAWIAVGTNQDKPGEIGIIICLAMLI 1147

  Fly  1004 TGTVQWTVRQSAELENTMISVERMIEYEEIEPEGP--------------LEATADKKPHESWPEQ 1054
            .||.||.|..|..::..|.||:|:.::.::..|.|              ::|.||    .|||.:
Zfish  1148 LGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSETPKPDKGKDSDLIIENVDAQAD----SSWPHR 1208

  Fly  1055 GKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRID 1119
            |:||...|:::|..  ...:|||:|||..:.:::|||:||||:|||||.|||.:|.|.||.:.||
Zfish  1209 GQIEVRNLTVKYTE--AGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLVYTDGEISID 1271

  Fly  1120 DKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGL 1184
            ..:.|.|.|...|....::||:..:|:|.:|.||||:..:||:.||...|||.||.|:......|
Zfish  1272 GVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVIEQFPDKL 1336

  Fly  1185 ETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTV 1249
            :.::..||...|.|.:||:||||:||...|||::||.:|::||.|..:::.|:|..|..||:|..
Zfish  1337 DFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKKTLRQSFSTCTILLS 1401

  Fly  1250 AHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKS 1314
            .|::..:::....|:||.|:|..:.:..:||  ::|:..:..:....:      ||:..|.....
Zfish  1402 EHKVEPLLECQSFLMMDKGQVKTYDSIQKLL--NETSHLKQAISPAER------LKLFPRRNSSM 1458

  Fly  1315 EKPSLMLPS 1323
            ..|...|.|
Zfish  1459 RTPQSKLSS 1467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31792NP_724148.2 PLN03130 7..1313 CDD:215595 422/1492 (28%)
cftrNP_001038348.1 CFTR_protein 1..1485 CDD:273530 425/1504 (28%)
Disordered R region. /evidence=ECO:0000250|UniProtKB:P13569 653..826 17/178 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1485 4/16 (25%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P13569 1483..1485
Blue background indicates that the domain is not in the aligned region.

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