DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_005155817.1	Gene:	abcc10 / 556709	ZFINID:	ZDB-GENE-050517-24	Length:	1548	Species:	Danio rerio

Alignment Length:	1381	Identity:	469/1381 - (33%)
Similarity:	716/1381 - (51%)	Gaps:	173/1381 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSALSFWYTIPTFIKGQKVTLG-AKDLYRALKEHRAESL----------------------- 57
            |::.|.|.:.:..|...:|::..|| ..|::......|.:|:
Zfish   231 SSLLSRLLYLWLNPLLNRGKRGELGRPSDVFELPSRLRTKSVTRRFYQCWEKCLHSRALERPERP 295

  Fly    58 -----GNKLCSSWA---------NELETNKKNASLLRVLFRVFG-RYFVFLGLVLFCLEVILTVQ 107
                 ||...:||:         .|.|...|   ||:||.:.|| ||::..||.|.. .::....
Zfish   296 DRRPRGNLQDNSWSEAQPERICEGEAEHEVK---LLQVLHKAFGLRYYLLGGLKLVA-SMLAFAG 356

  Fly   108 PMFLMKLISSF-SNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYR 171
            |:.|..|:... :..:|.|.||..|.  |:...:.|..:|.|.:.:.|:.:.|:.|..|.|.||.
Zfish   357 PLLLGGLVGFMETEGAPLSKGVWCAV--GLFASTFLAALLKNIFVYEVSKVALEARAAVISTIYC 419

  Fly   172 KCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGM 236
            |.|::....|...:.|.::|.:|.|..|:..|....|.:|..|.|.::..||:|.::|:|.:.|:
Zfish   420 KALKVNAPSLARFNMGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYLQVGVAFLGGV 484

  Fly   237 TFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKE 301
            ...:|.:||...|..:|...........|.|:::||||:.||:|:|.|.||..|.:.:..||.||
Zfish   485 GVAVLLVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHFTQKIEEARKKE 549

  Fly   302 INSIRHVAY--AKCL-IWSFNRFLTPVSI-FLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTA 362
            ::.::.:.|  |.|: .|:    ..||.| .|:.:.:||:|..|||...|...|...::...:.|
Zfish   550 LHHLKLLKYLDAVCVYTWA----ALPVVISILTFITYVLLGNNLTAAKVFSTLALVGMLILPLNA 610

  Fly   363 YFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPP 427
            :..| :..|.|..||:.|:|:.|..              .::||.....::        .||.||
Zfish   611 FPWV-LNGTLEAKVSLDRIQRFLAV--------------QDQDLSVYYSQV--------CPEDPP 652

  Fly   428 ------------HNSEDCVSISELKAKWTTNSP--DYTLSGVNLQVHAGALVAIVGHTGSGKSSL 478
                        ..||:..|:|.........||  .:.|..:||.|..|:||.:||..|.|||||
Zfish   653 SAVQMVQASFSWKQSEEADSVSIPDDITEEGSPPRSFYLHALNLNVKMGSLVVVVGKVGCGKSSL 717

  Fly   479 IQAILGELRVESGEIEVTG---SMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERD 540
            :.||.|||....||:.|.|   ....|.||||:...||:.|||||:..|...|..|::.|||..|
Zfish   718 LAAITGELTRCGGEVFVQGREQGFGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADD 782

  Fly   541 FELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGH 605
            ..:||..|:|.:|:.|.:||||||:|::|||:||.|..||||||||:|||:.||..|.|:|:.|.
Zfish   783 LNILPGGDQTEVGENGVTLSGGQKSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGI 847

  Fly   606 LRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYE---SLHKSGLDFGIVLDDPVNDNEAAED 667
            |:||..||.||:::|:.:||.:|:|:.|.:...|...   ||.|..       .|..|.:.|.|.
Zfish   848 LKDKTRILCTHRIEFVDKADVVVLMDNGMIVKTGAPSEVLSLVKGP-------KDSKNSSNAKEK 905

  Fly   668 RSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSV 732
            .|..|...:.....:|:.|       |..|||||      |:|.....||..|::|.||.::.:|
Zfish   906 DSAGSEEMEASEPELKAEL-------EMFGEEQK------QMGTLSWAVYRSYWKAVGGCMAVAV 957

  Fly   733 VMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDA--------------------------- 770
            ::..|: .|...::.|::||.|:|..:..:....:..|
Zfish   958 LLALFL-MQASKNVSDWWLSHWISHMKDNMTELVSVSATPLLMLSFLSPGRLVFNAPARGSESSG 1021

  Fly   771 ---KDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNP 832
               .:..|.|   .:|..:...:.:.|..|:|||...|:.|:..:|..:...:.:|:|.||:..|
Zfish  1022 NMSSELKFYM---TVYGSLAAANTVFTAARAFLFAYGAICAATVVHKRLLSSVLKATMTFFDTTP 1083

  Fly   833 AGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFG--GNIIVIAIVNPLFLIPALAFGIVIYYLRS 895
            .|.||||||.|:..||:.||.::..::.:  :||  |.:||::...|..|:|.:..|.:.|..:.
Zfish  1084 LGRILNRFSSDIYSVDDSLPFVLNILLAN--VFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQC 1146

  Fly   896 FYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTS 960
            ||..:|.::|||.:.|.|||||||:.:|:||||:|  |:|.....|.:..:.:..:...:|  .|
Zfish  1147 FYRYSSRELKRLCSLTLSPVYSHFSETLSGLSTVR--GSGHTTRFEEENERRLEQNQRCLF--NS 1207

  Fly   961 RAFAYWMDI----FCVLFIAMITLSFFIFPPSSAAD---VGLAITQAMGLTGTVQWTVRQSAELE 1018
            .|...|:||    ..|..:..|::...|.....:.|   |||:::.|:.:|..:...:...|:.|
Zfish  1208 NAAMQWLDIRLQMIAVTVVTGISVIAVIQHQLKSIDPGLVGLSLSYALSITNLLSGLIFSYAQTE 1272

  Fly  1019 NTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVI 1083
            ..::|:||..||....|:.|.:|:.:..  :.|||:.::|||::.|.|.|.|  .:.|..:|..:
Zfish  1273 MQLVSIERTEEYSTSIPQEPQQASLEVL--DRWPERARVEFVDVVLSYRPGL--PNALDGVSVEV 1333

  Fly  1084 KPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSG 1147
            .|.||:|||||||:|||||..||||: ..|.|.:.:|..|.:.:.|.|||||::||||:|.|||.
Zfish  1334 LPGEKIGIVGRTGSGKSSLFLALFRMVELNQGQILLDGVDISSVRLSDLRSKLAIIPQDPFLFSS 1398

  Fly  1148 TVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRD 1212
            :||.||||...:.|.||..|||:..|.:||.... ||::::.|.|.:.|||||||:|||||:|.:
Zfish  1399 SVRENLDPHGRHPDYRLLEALEQCHLGNVVQRNG-GLDSEVGERGKSLSVGQRQLLCLARALLTE 1462

  Fly  1213 NRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPY 1277
            ..||.:|||||:||.:||.|:|.|||.||::.||||:||||:||||||:||||.||:||||.:|.
Zfish  1463 ANILCIDEATASVDQKTDMLLQKTIREKFKDKTVLTIAHRLNTIMDSDKVLVMHAGKVVEFDSPA 1527

  Fly  1278 ELLTADDTNAFQDLVK 1293
            .|...:| :|||.|::
Zfish  1528 TLCQRED-SAFQKLLR 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	464/1367 (34%)
		ABC_membrane	94..360	CDD:294371	80/270 (30%)
		ABCC_MRP_domain1	434..634	CDD:213217	95/204 (47%)
		ABC_membrane	736..980	CDD:294371	77/279 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	120/221 (54%)
abcc10	XP_005155817.1	SunT	248..1531	CDD:331423	460/1350 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650