DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc8

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_005170744.1	Gene:	abcc8 / 553281	ZFINID:	ZDB-GENE-050517-22	Length:	1594	Species:	Danio rerio

Alignment Length:	1422	Identity:	435/1422 - (30%)
Similarity:	709/1422 - (49%)	Gaps:	212/1422 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFI------------------------------------KGQKVT--LGAKD 44
            |:.|..::|: :.|||                                    ||.:.|  .|:|.
Zfish   236 NLLSKSTYWW-MNTFITSAHRRPIDLKVIGRLPIAMRALTNYIKLRQAFEAQKGPQDTPPQGSKW 299

  Fly    45 LYRALKEHRAESLGNKLCSSWANELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVIL----- 104
            ::.||:    ::.|..|                :|.:.:|.......|.|.:  |:..|:
Zfish   300 IWAALR----QAFGKPL----------------ILSITYRFMADLLGFAGPL--CISGIVHHLSK 342

  Fly   105 ---TVQPMFL---MKLISSFSNPSPTSNGVAYAYAGGVILGSAL---KVILMNPYSFAVTHLGLK 160
               |:.|...   |..|||       ...:|..|...|:|..||   :..|...|..|: ..|:.
Zfish   343 ENHTILPPVKHLGMYFISS-------QEFLANGYVLAVLLFFALLLQRTFLQASYYVAI-ETGIN 399

  Fly   161 IRVGVSSMIYRKCLRLTKTDL--GEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYL 223
            :|..:.:.|:.|.:||..::|  |.::.|.|.||::.|..::..|......|:..|:|.::...|
Zfish   400 LRGAIQTKIFNKIMRLCTSNLSMGGMTVGQICNLVAIDTNQLMWFFFLCPNLFAMPVQIIVGIIL 464

  Fly   224 MYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWEL 288
            :|..:||:|:.|.|.|.|..|:|.::..|:|..:..|...|.:|::...|::.||:::|:||||.
Zfish   465 LYYLLGISALIGATIITLLAPVQYFVATKLSDAQKSTLEYSSERLKKTNELLRGIKLLKLYAWEH 529

  Fly   289 PFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFL-TPVSIFLSLVGFVLMGRF-----LTAEVAF 347
            .|...|...|.||:.|::  |:|  |..|.:.|: |.:.|...||.||.....     |:..|||
Zfish   530 IFCSNVEETRCKELTSLQ--AFA--LYTSISIFMNTAIPIAAVLVTFVAHVHLSDDADLSPAVAF 590

  Fly   348 LITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDE---NVVSNGAEEDLQEA 409
            ...:.::::.|.:....|| |..|.:.|||::::.:.....|:..:.|   .||.|....:..:|
Zfish   591 ASLSLFHILVTPLFLLSSV-VRSTVKALVSVQKLSEFFSCDEIGGEQEPRATVVPNSTNHNKYQA 654

  Fly   410 REKLLVTPTPMRAPEKPPHNS----------------ED-CVSISELKAKWTTNSPDYTLSGVNL 457
            ....:|.   .:.|.:...||                || |:.|:.....||..:.  |||.||:
Zfish   655 LPLKVVN---RKRPVREDWNSFALQSEQEDEVLAVGDEDICIKITNGYFSWTEGTS--TLSNVNI 714

  Fly   458 QVHAGALVAIVGHTGSGKSSLIQAILGELR-------------------------VESGEIEVTG 497
            ::..|.|..|||..|.|||||:.|.|||::                         ...|:|...|
Zfish   715 KIPFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMPTLDAEGNESLPDAAAEGDIRKRG 779

  Fly   498 SMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGG 562
            :::||||:|||.:.|:.:||.|..|:.::||..|:..|:|:.|.::||..|:||:|:||..||||
Zfish   780 AVAYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQPDIDILPQGDQTIIGERGIILSGG 844

  Fly   563 QKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQAD 625
            |:.|||:||::|:..::..||||.||:|..::..|.:|.:...||:  :.|::|||:||:|..||
Zfish   845 QRQRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQEGILKLLREEKRTVVIVTHKLQYLPHAD 909

  Fly   626 QIVIMEMGKVKAVGTYESLHKS----------------------GLDFGIVLDDPVNDNEAAEDR 668
            .|:.|:.|.::..||.:.:.||                      .:|..:.:.:..|...|...|
Zfish   910 WIIAMKDGSIQTEGTLKDIQKSQPELFEQWKTLMHRQDKEFEKETVDENMTVLERKNLRRAMYSR 974

  Fly   669 SRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVV 733
            ....:..|:...|::|         :|.....::...|..:.....|.|:    :..|.|...::
Zfish   975 EALKTEEDEEEESLES---------DDDDNLSQVMRHRATIPWRSCGTYL----SSAGLLLLLLL 1026

  Fly   734 MTFFVCSQGLASLGDYFLSPWVSR--NEKM--VAHNYTTDAKDADFEMHAAY--IYMLITVLSIM 792
            :...:....|....||:|:.|.|:  ..|:  .|||.:. .:|..| .|::|  ::.|:..|.|:
Zfish  1027 LLSQLLKHSLLVAIDYWLAHWTSKVITAKIDAAAHNCSL-VQDIGF-THSSYLLVFSLLCCLGIV 1089

  Fly   793 VTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMT 857
            :.:..|.......:|.:.:||:::...|..|.|..|...|.||||||||.|...:|:.:|..:..
Zfish  1090 LCLATSVAVEWTGLRVAKELHHNLLSNIILAPMRLFETTPLGSILNRFSSDTNTIDQHIPATLEC 1154

  Fly   858 VIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAAS 922
            :.:..||....:.||:.|.|:|||......|..|:::.::...|.|:::||.||:.|:.|||:.:
Zfish  1155 LSRSTLLCVSALGVISYVTPVFLIVLAPLTIACYFIQKYFRVASKDLQQLEDSTQLPLLSHFSET 1219

  Fly   923 LNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI------FCVLFIAMI-TL 980
            :.||:|||||............:.|.::.||....:.:|    |:::      .|::.||.: ::
Zfish  1220 VEGLTTIRAFRYEPRFRQRLLQFTDANNMASLFLTAANR----WLEVRMEYIGACIVLIAAVASI 1280

  Fly   981 SFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEP---EGPLEAT 1042
            :..::...|...|||.:|.|:.::..:.|.||..|::|..:.:|:|:......||   ||.|.|:
Zfish  1281 TNSLYSHLSTGLVGLGLTYALMVSNYLNWMVRNLADMEVQLGAVKRIKALLRTEPENYEGLLSAS 1345

  Fly  1043 ADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALF 1107
               :..|.||:||:|:...||:||:..||  .|||.::..|||.:|:||.||||:||||...|.|
Zfish  1346 ---QVPEGWPQQGEIQIQNLSVRYDSTLK--PVLKHVNAHIKPGQKLGICGRTGSGKSSFSLAFF 1405

  Fly  1108 RL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEV 1171
            |: ...:|.:.|||.|...:.|..|||:.|||.|:|.|||||:|.||||..:.:|..||.|||..
Zfish  1406 RMVDTFEGRIIIDDIDIAKLPLQTLRSRFSIIQQDPFLFSGTIRFNLDPEMKATDSMLWEALEIA 1470

  Fly  1172 ELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQAT 1236
            :||.||.::..||:..|||||.|||.|||||.|||||.:|.:.||:||||||::|..|::::|..
Zfish  1471 QLKPVVKTLPGGLDAIITEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATESILQKV 1535

  Fly  1237 IRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVK 1293
            :...|.:.||:|:|||:|||:::|.|:||..|.::||..|..||..:| :.|...|:
Zfish  1536 VMTAFADRTVVTIAHRVHTILNADLVIVMKRGVILEFDKPEVLLDQED-SVFASFVR 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	431/1408 (31%)
		ABC_membrane	94..360	CDD:294371	81/287 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/226 (38%)
		ABC_membrane	736..980	CDD:294371	73/256 (29%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/221 (50%)
abcc8	XP_005170744.1	MRP_assoc_pro	39..1591	CDD:188098	434/1420 (31%)
		ABC_membrane	<388..603	CDD:294371	65/219 (30%)
		P-loop_NTPase	693..918	CDD:304359	85/226 (38%)
		ABC_membrane	1038..1307	CDD:279056	78/274 (28%)
		P-loop_NTPase	1355..1594	CDD:304359	117/240 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650