Protein Alignment CG31792 and ABCC1

DIOPT Version :10

• Sequence 1: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: XP_047290087.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1584
• Species: Homo sapiens
• Alignment Length: 1386
• Identity: 462/1386 - (33%)
• Similarity: 721/1386 - (52%)
• Gaps: 167/1386 - (12%)

  Fly    13 PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKK--- 74
            |...::..|.::||:.....::|.:..|...||:...||..:|.:...|..:|..|....:|
Human   262 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 326

  Fly    75 ------------------------------------NASLLRVLFRVFGRYFVFLGLVLFCLEVI 103
                                                |.||.:||::.||.||    |:.|..:.|
Human   327 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYF----LMSFFFKAI 387

  Fly   104 LTVQPMF----LMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVG 164
            ..:. ||    ::||:..|.|.:...:...|.|...:.:.:.|:.::::.|.......|::|:..
Human   388 HDLM-MFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTA 451

  Fly   165 VSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIG 229
            |...:|||.|.:|.:.....:.|.|:||:|.|..|......:.:.:|.||||.::..||::..:|
Human   452 VIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLG 516

  Fly   230 IAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMV 294
            .:.:.|:..::|.:|:...:..|....::......|.|:::|.||:.||:|:|:|||||.|:..|
Human   517 PSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKV 581

  Fly   295 AHARHKEINSIRHVAYAKCL---IWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVV 356
            ...|.:|:..::..||...:   .|....||..:..|...| .:.....|.|:.||:..|.:|::
Human   582 LAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYV-TIDENNILDAQTAFVSLALFNIL 645

  Fly   357 RTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMR 421
            |..:.....| ::...:..||:||: ::.||.|.:           |.|..|            |
Human   646 RFPLNILPMV-ISSIVQASVSLKRL-RIFLSHEEL-----------EPDSIE------------R 685

  Fly   422 APEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGEL 486
            .|.| .....:.:::......|..:.|. ||:|:...:..|||||:||..|.|||||:.|:|.|:
Human   686 RPVK-DGGGTNSITVRNATFTWARSDPP-TLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEM 748

  Fly   487 RVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTI 551
            ....|.:.:.||::|..|:.|:.:.::|:|||||..::...|..|::.|||..|.|:||..|:|.
Human   749 DKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTE 813

  Fly   552 LGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILV 614
            :|::|.:||||||.|:||||:||.:|.|||.||||||||:.|.:.:||..:  :|.|::|..|||
Human   814 IGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILV 878

  Fly   615 THQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVL--------DDPVNDN--------- 662
            ||.:.:|.|.|.|::|..||:..:|:|:.|......|...|        :....:|
Human   879 THSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPG 943

  Fly   663 EAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDV-------GEEQKINLQRQ-----------QL 709
            :.|:.......:||.....::..||.:.|...|:       .|.||...:::           |.
Human   944 KEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQT 1008

  Fly   710 GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDAD 774
            |:..|.||.||.:|.|.|:||..:. .|:|:...|...:|:||.|.  ::.:|  |.|.:.....
Human  1009 GQVKLSVYWDYMKAIGLFISFLSIF-LFMCNHVSALASNYWLSLWT--DDPIV--NGTQEHTKVR 1068

  Fly   775 FEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQ-------LHNSMFRGISRASMYFFNKNP 832
            ..::.|            :.|.:....|..:|..||.       ||..:...|.|:.|.||.:.|
Human  1069 LSVYGA------------LGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTP 1121

  Fly   833 AGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPL--FLIPALAFGIVIYYLRS 895
            :|:::|||||::..||.|:|.:|...:.......|..|||.:..|:  .:||.|  |::.::::.
Human  1122 SGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPL--GLIYFFVQR 1184

  Fly   896 FYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTS 960
            ||:.:|..:||||:.:||||||||..:|.|:|.||||........:.|...|.:..|.|..|..:
Human  1185 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1249

  Fly   961 RAFAYWMD-------IFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELE 1018
            |..|..::       :|..||..:...|.      ||..|||:::.::.:|..:.|.||.|:|:|
Human  1250 RWLAVRLECVGNCIVLFAALFAVISRHSL------SAGLVGLSVSYSLQVTTYLNWLVRMSSEME 1308

  Fly  1019 NTMISVERMIEYEEIEPEGP--LEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSF 1081
            ..:::|||:.||.|.|.|.|  ::.||   |..|||:.|::||....|||...|  :.||:.::.
Human  1309 TNIVAVERLKEYSETEKEAPWQIQETA---PPSSWPQVGRVEFRNYCLRYREDL--DFVLRHINV 1368

  Fly  1082 VIKPKEKVGIVGRTGAGKSSLINALFRLSYN-DGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLF 1145
            .|...||||||||||||||||...|||::.: :|.:.||..:...:||||||.||:||||:||||
Human  1369 TINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1433

  Fly  1146 SGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAIL 1210
            ||::|.|||||.:|||:.:|.:||...|||.|:::...|:.:..|||.|.|||||||||||||:|
Human  1434 SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALL 1498

  Fly  1211 RDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGT 1275
            |..:|||:|||||.||.:||.|||:|||.:|.:|||||:||||:||||..||:|:|.|.:.|:|.
Human  1499 RKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGA 1563

  Fly  1276 PYELLTADDTNAFQDLVKQTG 1296
            |.:||  .....|..:.|..|
Human  1564 PSDLL--QQRGLFYSMAKDAG 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	462/1386 (33%)
ABCC1	XP_047290087.1	MRP_assoc_pro	70..1583	CDD:188098	462/1386 (33%)