DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Mrp4

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster

Alignment Length:	1347	Identity:	722/1347 - (53%)
Similarity:	969/1347 - (71%)	Gaps:	64/1347 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW 65
            |||.|.::|||||||||:..|:|.|.:.:|...||:|.||..||||||||||:::|||::||::|
  Fly     1 MQSMKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAW 65

  Fly    66 ANELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTV-QPMFLMKLISSFSNPSPTSNGVA 129
            ..::..| :...|.|.|.:|||.:....|:.|...|.:..| ||:.|:.:::.|:...| ....|
  Fly    66 DEQVAKN-ETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGNDP-DRSKA 128

  Fly   130 YAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLIS 194
            ..:|.|:|.||...|.:.:||...:.|||:|:|:.:||:||||.|||::|.||:.:.|.::||:|
  Fly   129 QLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLLS 193

  Fly   195 NDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLK 259
            ||:||.|..:...||||:|||:.:.||||||.||||:::||:..:|||:|.|.||||:.|.|||:
  Fly   194 NDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRLR 258

  Fly   260 TAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTP 324
            ||:|:|:|:|:|.|||:|||||||||||.||.|:|...|..|:..|:.|.|.:.::.||..||:.
  Fly   259 TALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLSR 323

  Fly   325 VSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE 389
            :....||:.|||:|..|.||.||.:|||||::|.::|.:|..|:::.||.|||::|::..:...|
  Fly   324 IFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRPE 388

  Fly   390 VVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAP--EKPPHNS--EDCVSISELKAKWTTNSPDY 450
            ...:|::.|.|        |.:|       ..:|  :.|..|.  |:.:..|:.:|:|.::|.:.
  Fly   389 TKVRDKSKVKN--------ANQK-------AESPNGDSPKGNGIPENLIEFSQFQARWESHSLEP 438

  Fly   451 TLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQ 515
            ||..:|||:....|||::|..|:|||||||||||||..|||.:.:.||.|||:||||||:|||||
  Fly   439 TLEDINLQLGRRKLVAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQ 503

  Fly   516 NILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIY 580
            |||||...|:.||..||:||||||||||||..||||:|:|||||||||||||||||:|||.|.||
  Fly   504 NILFGLDWDKHRYRTVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIY 568

  Fly   581 LLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLH 645
            ||||||||||:.|.|.||::|:||:||.::|||||||||||:|||.||||:.|::.|:|||.|:.
  Fly   569 LLDDPLSAVDTHVGRHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMK 633

  Fly   646 KSGLDFGIVLDDPVNDNEAAED----------------------RSRTSSITDQRRSSVKSVLSH 688
            :|||||..:|..|   |:.|||                      |...:|....|.:|..|:.|.
  Fly   634 RSGLDFAQLLTAP---NKDAEDLDEIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSM 695

  Fly   689 AESCPEDVGEEQKINLQRQQL-GRNGLGVYVDYFRAGGGFLSFSVVMTFFVC--SQGLASLGDYF 750
            |||    :.:|..:.:|..:: |:.|||:|.:|..:|..:  |.:....|:|  :|.|.|..|||
  Fly   696 AES----MAQEASLQMQETRVEGKIGLGLYKEYLTSGSSW--FMIFFMVFLCLATQILCSAADYF 754

  Fly   751 LSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNS 815
            ||.||.:|..... :..||.:|       .|.:..:.|..::.||.|:.||:.:|||:|.||||:
  Fly   755 LSYWVDKNVDGQT-DINTDPQD-------MYYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNA 811

  Fly   816 MFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFL 880
            |::||:||:|||||.||:|.||||||||:||:||:||::::.|:|.||...|.|:||.|.||.:|
  Fly   812 MYQGITRAAMYFFNTNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYL 876

  Fly   881 IPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGY 945
            |..||..|:.||:|.||||||.|||||||..|||:|||.:|::.||.||||.||...|.||||..
  Fly   877 ILTLALAIIFYYIREFYLKTSRDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELIAEFDNL 941

  Fly   946 QDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWT 1010
            ||:|||..|.|::|:|||.|::|.||.|:|.:|.|::||.||.|..:||||||||||:||.|||.
  Fly   942 QDLHSSGYYTFLATNRAFGYYLDCFCTLYIVIIILNYFINPPQSPGEVGLAITQAMGMTGMVQWA 1006

  Fly  1011 VRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESV 1075
            :||||||||||.:|||::||:||||||..::...|||..||||:|:|...:|.|||.|..:::.|
  Fly  1007 MRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYV 1071

  Fly  1076 LKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQ 1140
            ||:|:|.|:|.||||||||||||||||||||||||||:|.:.||::||.||||.|||||||||||
  Fly  1072 LKALNFRIRPCEKVGIVGRTGAGKSSLINALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQ 1136

  Fly  1141 EPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCL 1205
            |||||||::|:|||||:||:|.:||.|||||:||.:::.:..||::||:||||||||||||||||
  Fly  1137 EPVLFSGSMRYNLDPFEEYNDAKLWDALEEVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCL 1201

  Fly  1206 ARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRV 1270
            ||||||:||:|||||||||||||||||||||||:|||:|||||:||||:||||||||||||||.:
  Fly  1202 ARAILRENRVLVMDEATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHL 1266

  Fly  1271 VEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKP 1317
            ||||:||||||:.::..|..:|.:|||.|:|:|||::::...:|.||
  Fly  1267 VEFGSPYELLTSSESKIFHGMVMETGQNTFDSLLKVAEKAHLESMKP 1313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	700/1298 (54%)
		ABC_membrane	94..360	CDD:294371	127/266 (48%)
		ABCC_MRP_domain1	434..634	CDD:213217	133/199 (67%)
		ABC_membrane	736..980	CDD:294371	128/245 (52%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	166/220 (75%)
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	700/1298 (54%)
		ABC_membrane	93..359	CDD:294371	127/266 (48%)
		ABCC_MRP_domain1	422..622	CDD:213217	133/199 (67%)
		ABC_membrane	735..978	CDD:294371	129/250 (52%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	166/220 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440880
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810