DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc2

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1443	Identity:	483/1443 - (33%)
Similarity:	738/1443 - (51%)	Gaps:	225/1443 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLY--------------------RALKEHRAE 55
            ||..::...|.::| |:....: ||.|..|..:|::                    :.||:.| .
Zfish   207 NPEAKATFLSRITFNWFNSMVW-KGFKRPLVQEDMWDLNKNDSTHFICQTFEDVMAKELKKAR-N 269

  Fly    56 SLGNK------------------------LCSSWANELETNKKNAS-------------LLRVLF 83
            :|..|                        |......|.|:.||...             |:..:.
Zfish   270 NLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDSDYPQSWLVTTIV 334

  Fly    84 RVFGRYFVFLGLVLF-CLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILM 147
            :.|..  |.|...|| .|:.:|:.....|:||:.:|:....:.....|.||..::|.:.::.:::
Zfish   335 KSFKG--VLLESALFKLLQDLLSFASPQLLKLMIAFTQNKDSYAWTGYLYAVLLVLVAFVQSVVL 397

  Fly   148 NPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWL 212
            ..|......||:|:|..:.:.:|:|.|.::.....|.:.|.|:||:|.|..|.:....|.|.||.
Zfish   398 QQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVNLMSADAQRFNDVTNFIHLLWS 462

  Fly   213 APLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAG 277
            .|||..:....::.|:|.:.:.|:..::|.:|:..:|..|....:::.....|.||:|:.:::.|
Zfish   463 CPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSRQFQMQNMKFKDSRMKIVNDLLNG 527

  Fly   278 IQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFL--------SLVGF 334
            |:::|.||||..||..|...|.||:..:|..||           |:.||.|:        ||..|
Zfish   528 IKILKYYAWETSFEAQVQEIREKELKVMRKFAY-----------LSSVSTFIFSCAPALVSLATF 581

  Fly   335 VLM-----GRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE----- 389
            .:.     ...|.||.||...:.:|::|..: |.....::...:|.||.||::| .|||:
Zfish   582 AVFVSVSPDNILDAEKAFTSISLFNILRFPL-AMLPQLISIMVQTSVSKKRLEK-FLSGDDLDTT 644

  Fly   390 VVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSG 454
            .|..|.::.:                                 .||::.....|..:: :..|..
Zfish   645 TVTHDSSITA---------------------------------AVSMTNGTYAWERDT-EPVLKR 675

  Fly   455 VNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILF 519
            |:|.:..|.|||:||..||||:||:.|:||||....|.|.:.||::|..|:.|:.:.|::.||||
Zfish   676 VSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQAWIQNATLKDNILF 740

  Fly   520 GQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDD 584
            |..:|..||..|::.|||..|.:|||.:|:|.:|::|.:||||||.|:||||:||..|.:|||||
Zfish   741 GSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLARAVYSSADVYLLDD 805

  Fly   585 PLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKS 647
            |||||||.|.:.|||:.:  .|.||||..||:||.:.||...|:||::..|.|..:|:||||..|
Zfish   806 PLSAVDSHVGKHLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHGVVSEIGSYESLRAS 870

  Fly   648 GLDFGIVLD-------DPVNDNEAA-----------------------------------EDRSR 670
            ...|...|:       :..||.:||                                   |:..|
Zfish   871 KGAFSEFLETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPEDIVSSTLKRENSLR 935

  Fly   671 TSSITDQRRSSVK----SVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRA-GGGFLSF 730
            .|....:|..|||    |.| .|:..|||...::.|..:..:.||....||:.|..| |..::.|
Zfish   936 HSQRHSKRNGSVKVRKNSSL-RAQKDPEDKKGQRLIEKEMMETGRVKFSVYLQYLSAMGWWYVGF 999

  Fly   731 SVVMTFFVCSQGLASLG-DYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVT 794
            |.|..|.   |.:|.:| :.:||.|...:.:.....|....:|....:..|            :.
Zfish  1000 SFVFYFI---QNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIRDTRIGVFGA------------LG 1049

  Fly   795 IKRSFLFF-------NLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLP 852
            :.:.||.|       :.::.||..||.|:...|.:..|.||:..|:|.|:|||:||:..||||:|
Zfish  1050 LAQGFLVFFGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGRIVNRFAKDIFTVDEMIP 1114

  Fly   853 TIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYS 917
            ....:.|...|...|.:.||.:..|:|....:...:|.|:::.||:.||..::||::.:|||:||
Zfish  1115 MSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVATSRQLRRLDSVSRSPIYS 1179

  Fly   918 HFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIF--CVLFIAMITL 980
            ||..:::|||.|||:|.........:...|.:..:.|.:|.::|..|..::..  .|:|.|.:
Zfish  1180 HFGETVSGLSVIRAYGHQDRFLKRNEHTIDQNLKSVYPWIVSNRWLAMRLESLGNLVVFFAAL-- 1242

  Fly   981 SFFIFPPSS--AADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATA 1043
             |.:....|  :..|||:|:.|:.:|.|:.|.||.::|||..:::|||:.||.||:.|.|...:.
Zfish  1243 -FAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVERVREYAEIQNEAPWVTSV 1306

  Fly  1044 DKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR 1108
              :|.:.||..|.|.|.:..:||.|.|  |.||..::..|:..||:|||||||||||||.|.|||
Zfish  1307 --RPPDDWPSAGNIRFEDYKVRYRPEL--ELVLHGVTCDIQSTEKIGIVGRTGAGKSSLTNCLFR 1367

  Fly  1109 L-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVE 1172
            : ...||.:.|||.|...:|||||||:::||||:|||||||:|.|||||..:||..:|..||...
Zfish  1368 IVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDPFQTFSDAEIWSVLELAH 1432

  Fly  1173 LKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATI 1237
            ||:.|..:.||||.:::|||.|.|:|||||:|||||:||.:|||::|||||.||.:||.|||:||
Zfish  1433 LKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDEATAAVDLETDDLIQSTI 1497

  Fly  1238 RNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDT 1302
            |.:|..|||||:||||:||:||.||:|:|:|::|||.:|.|||:  ....|..:.:..|
Zfish  1498 RREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELLS--KPGHFSSMAEDAG------ 1554

  Fly  1303 LLKISQREFEKSE 1315
                .:||.|:|:
Zfish  1555 ----IRREEEQSQ 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	476/1407 (34%)
		ABC_membrane	94..360	CDD:294371	76/279 (27%)
		ABCC_MRP_domain1	434..634	CDD:213217	95/201 (47%)
		ABC_membrane	736..980	CDD:294371	72/253 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	129/221 (58%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	479/1433 (33%)
		ABC_membrane	346..612	CDD:294371	76/276 (28%)
		ABCC_MRP_domain1	656..856	CDD:213217	95/200 (48%)
		ABC_membrane	1001..1270	CDD:279056	81/286 (28%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	129/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660