Protein Alignment CG31792 and ABCC6

DIOPT Version :10

• Sequence 1: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_001162.5
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1503
• Species: Homo sapiens
• Alignment Length: 1374
• Identity: 420/1374 - (30%)
• Similarity: 679/1374 - (49%)
• Gaps: 153/1374 - (11%)

  Fly    10 PENPRERSN--------IFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWA 66
            ||:| ::||        ..|..:||:......:|.:..|..|||:...:|:.:|.|.::|...|.
Human   194 PEDP-QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 257

  Fly    67 NE----------LETNKKNAS--------------------LLRVLFRVFGRYFVFLGLVLFCLE 101
            ..          :...:|..|                    ||:.:::||...|:...|.|...:
Human   258 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISD 322

  Fly   102 VILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVS 166
            |.....|..|...:....:|.|.: ...|..|..:.|.:.|:.:......:.:..|.:::|..::
Human   323 VFRFTVPKLLSLFLEFIGDPKPPA-WKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAIT 386

  Fly   167 SMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYL-MYQEIGI 230
            .::|||.|.|:.......:.|.::||:|.|:.|:...:.:.:.||| ||..::|.:: ::|.:|.
Human   387 GLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVWIVVCFVYLWQLLGP 450

  Fly   231 AAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVA 295
            :|:..:...|..:||..::.||.:..:.:...:.|.|.|:.:.|:...:.||.:.||..|...|.
Human   451 SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 515

  Fly   296 HARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFL-SLVGF----VLMGRFLTAEVAFLITAYYNV 355
            ..|.:|:.::|    ...|::|.:.....||.|| :||.|    ::....:.||.||:.....|:
Human   516 GIRGQELGALR----TSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNI 576

  Fly   356 VRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPM 420
            : ....|:....:....:..||..|:...|...||   |..||.:.:.....
Human   577 L-NKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV---DPGVVDSSSSGSAA------------- 624

  Fly   421 RAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGE 485
                     .:||::|......|:..||. .|..:||.|..|.|:|:||..|:|||||:.|:|||
Human   625 ---------GKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGE 679

  Fly   486 LRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKT 550
            |....|.:.:.|:::|..||.|:.:.:|.:|:.|||.:|....:.|:..|||:.|.:..|....|
Human   680 LSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHT 744

  Fly   551 ILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVIL 613
            .:|::|.:||||||.|:||||:|||.|::|||||||:|:|:.|.:.:|.:.:  .|.|:....||
Human   745 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRIL 809

  Fly   614 VTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITD-- 676
            |||.|..|.|||.|:::..|.:..:|:|:.|.:.......:||......:..|..:...:.|.
Human   810 VTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDP 874

  Fly   677 -----------QRRSSVKSVLSHAESCPEDVGEEQKINLQRQ---------QLGRNGLGVYVDYF 721
                       :|..|:|||.....:..|...|....:..|.         |.||....|::.|.
Human   875 RGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYL 939

  Fly   722 RAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLI 786
            ||.|..|.. ..:..|:|.|..:....|:||.|.  ::..|....|..|....
Human   940 RAVGTPLCL-YALFLFLCQQVASFCRGYWLSLWA--DDPAVGGQQTQAALRGG------------ 989

  Fly   787 TVLSIMVTIKRSFLFFNLA------MRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMG 845
             :..::..::...||.::|      .|||..|...:...:.|:.:.||.:.|.|.:||||||:..
Human   990 -IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053

  Fly   846 QVDEMLPTIIMTVIQDFLLFGGNI----IVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKR 906
            .||..:|    ..::..|::...:    :|:|:..||..:..|...::....:|.|:.:|..::|
Human  1054 TVDVDIP----DKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRR 1114

  Fly   907 LEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMD--- 968
            ||:::.|.|.||.|.:..|.:.:|||...:...|:.:...|.....|:..:...|..|..::
Human  1115 LESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLG 1179

  Fly   969 ---IFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEY 1030
               :|.....|:::.:..     ||..||.:::.|:.:|.|:||.||...:|||:::|||||.:|
Human  1180 NGLVFAAATCAVLSKAHL-----SAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDY 1239

  Fly  1031 EEIEPEGP--LEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVG 1093
            .....|.|  |...|.:.|   ||:.|:|||.:..|||.|.|  ...::.:||.|...|||||||
Human  1240 AWTPKEAPWRLPTCAAQPP---WPQGGQIEFRDFGLRYRPEL--PLAVQGVSFKIHAGEKVGIVG 1299

  Fly  1094 RTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFD 1157
            |||||||||.:.|.|| ...:|.:.||......:|||.|||:||||||:|:||.|::|.|||...
Human  1300 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQ 1364

  Fly  1158 EYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEAT 1222
            |:||:.:|.|||.|:||.:|||:...|:.|..:.|.:.||||:||:|||||:||..:||::||||
Human  1365 EHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1429

  Fly  1223 ANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNA 1287
            |.|||.|:..:||.:.:.|.:||||.:||||.::||..||||||.|:|.|.|:|.:||.  ....
Human  1430 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLA--QKGL 1492

  Fly  1288 FQDLVKQTG 1296
            |..|.:::|
Human  1493 FYRLAQESG 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	420/1374 (31%)
ABCC6	NP_001162.5	MRP_assoc_pro	14..1502	CDD:188098	420/1374 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..919		10/64 (16%)