DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31792 and ABCC6

DIOPT Version :9

Sequence 1:NP_001260548.1 Gene:CG31792 / 35163 FlyBaseID:FBgn0051792 Length:1323 Species:Drosophila melanogaster
Sequence 2:XP_024306029.1 Gene:ABCC6 / 368 HGNCID:57 Length:1515 Species:Homo sapiens


Alignment Length:1374 Identity:420/1374 - (30%)
Similarity:679/1374 - (49%) Gaps:153/1374 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PENPRERSN--------IFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWA 66
            ||:| ::||        ..|..:||:......:|.:..|..|||:...:|:.:|.|.::|...|.
Human   206 PEDP-QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWM 269

  Fly    67 NE----------LETNKKNAS--------------------LLRVLFRVFGRYFVFLGLVLFCLE 101
            ..          :...:|..|                    ||:.:::||...|:...|.|...:
Human   270 RNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISD 334

  Fly   102 VILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVS 166
            |.....|..|...:....:|.|.: ...|..|..:.|.:.|:.:......:.:..|.:::|..::
Human   335 VFRFTVPKLLSLFLEFIGDPKPPA-WKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAIT 398

  Fly   167 SMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYL-MYQEIGI 230
            .::|||.|.|:.......:.|.::||:|.|:.|:...:.:.:.||| ||..::|.:: ::|.:|.
Human   399 GLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWL-PLVWIVVCFVYLWQLLGP 462

  Fly   231 AAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVA 295
            :|:..:...|..:||..::.||.:..:.:...:.|.|.|:.:.|:...:.||.:.||..|...|.
Human   463 SALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVL 527

  Fly   296 HARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFL-SLVGF----VLMGRFLTAEVAFLITAYYNV 355
            ..|.:|:.::|    ...|::|.:.....||.|| :||.|    ::....:.||.||:.....|:
Human   528 GIRGQELGALR----TSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNI 588

  Fly   356 VRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPM 420
            : ....|:....:....:..||..|:...|...||   |..||.:.:.....             
Human   589 L-NKAQAFLPFSIHSLVQARVSFDRLVTFLCLEEV---DPGVVDSSSSGSAA------------- 636

  Fly   421 RAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGE 485
                     .:||::|......|:..||. .|..:||.|..|.|:|:||..|:|||||:.|:|||
Human   637 ---------GKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGE 691

  Fly   486 LRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKT 550
            |....|.:.:.|:::|..||.|:.:.:|.:|:.|||.:|....:.|:..|||:.|.:..|....|
Human   692 LSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSFPEGIHT 756

  Fly   551 ILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVIL 613
            .:|::|.:||||||.|:||||:|||.|::|||||||:|:|:.|.:.:|.:.:  .|.|:....||
Human   757 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRIL 821

  Fly   614 VTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITD-- 676
            |||.|..|.|||.|:::..|.:..:|:|:.|.:.......:||......:..|..:...:.|.  
Human   822 VTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALMCLLDQARQPGDRGEGETEPGTSTKDP 886

  Fly   677 -----------QRRSSVKSVLSHAESCPEDVGEEQKINLQRQ---------QLGRNGLGVYVDYF 721
                       :|..|:|||.....:..|...|....:..|.         |.||....|::.|.
Human   887 RGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYL 951

  Fly   722 RAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLI 786
            ||.|..|.. ..:..|:|.|..:....|:||.|.  ::..|....|..|....            
Human   952 RAVGTPLCL-YALFLFLCQQVASFCRGYWLSLWA--DDPAVGGQQTQAALRGG------------ 1001

  Fly   787 TVLSIMVTIKRSFLFFNLA------MRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMG 845
             :..::..::...||.::|      .|||..|...:...:.|:.:.||.:.|.|.:||||||:..
Human  1002 -IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1065

  Fly   846 QVDEMLPTIIMTVIQDFLLFGGNI----IVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKR 906
            .||..:|    ..::..|::...:    :|:|:..||..:..|...::....:|.|:.:|..::|
Human  1066 TVDVDIP----DKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQLRR 1126

  Fly   907 LEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMD--- 968
            ||:::.|.|.||.|.:..|.:.:|||...:...|:.:...|.....|:..:...|..|..::   
Human  1127 LESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLG 1191

  Fly   969 ---IFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEY 1030
               :|.....|:::.:..     ||..||.:::.|:.:|.|:||.||...:|||:::|||||.:|
Human  1192 NGLVFAAATCAVLSKAHL-----SAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDY 1251

  Fly  1031 EEIEPEGP--LEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVG 1093
            .....|.|  |...|.:.|   ||:.|:|||.:..|||.|.|  ...::.:||.|...|||||||
Human  1252 AWTPKEAPWRLPTCAAQPP---WPQGGQIEFRDFGLRYRPEL--PLAVQGVSFKIHAGEKVGIVG 1311

  Fly  1094 RTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFD 1157
            |||||||||.:.|.|| ...:|.:.||......:|||.|||:||||||:|:||.|::|.|||...
Human  1312 RTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQ 1376

  Fly  1158 EYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEAT 1222
            |:||:.:|.|||.|:||.:|||:...|:.|..:.|.:.||||:||:|||||:||..:||::||||
Human  1377 EHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEAT 1441

  Fly  1223 ANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNA 1287
            |.|||.|:..:||.:.:.|.:||||.:||||.::||..||||||.|:|.|.|:|.:||.  ....
Human  1442 AAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLA--QKGL 1504

  Fly  1288 FQDLVKQTG 1296
            |..|.:::|
Human  1505 FYRLAQESG 1513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31792NP_001260548.1 CFTR_protein 12..1281 CDD:273530 414/1355 (31%)
ABC_membrane 94..360 CDD:294371 65/271 (24%)
ABCC_MRP_domain1 434..634 CDD:213217 84/201 (42%)
ABC_membrane 736..980 CDD:294371 59/259 (23%)
ABCC_MRP_domain2 1055..1276 CDD:213211 117/221 (53%)
ABCC6XP_024306029.1 SunT 14..1514 CDD:331423 420/1374 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151599
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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