DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and MRP

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1379	Identity:	475/1379 - (34%)
Similarity:	740/1379 - (53%)	Gaps:	153/1379 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKN 75
            |.|...::..|.:::.:.....:||.:..|..|||:....:.....:.......|...:..|.||
  Fly   223 EIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKN 287

  Fly    76 -------------------------------ASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPM 109
                                           ||::..:::.||..|:|..|:....:.:...||.
  Fly   288 KARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQ 352

  Fly   110 FLMKLISSF---SNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYR 171
             ::.||.||   .:..|...|:.||....|:  :|.:..::..|...:..:||:||..:.:.|||
  Fly   353 -VLSLIISFVEAQDAEPEWKGILYAVLLFVL--AAAQTFILGQYFHRMFIVGLRIRTALINAIYR 414

  Fly   172 KCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYL---WLAPLQALMVTYLMYQEIGIAAV 233
            |.||::.:...|.:.|.|:||::.|..|   |::.|.||   |.||||..:..|.::|::|.:.:
  Fly   415 KALRISNSTKKESTVGEIVNLMAVDAQR---FMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVL 476

  Fly   234 FGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHAR 298
            .|:..:::.||:...:..:|...:::.....|:|:::|.|:::||:|:|:||||..|||.|...|
  Fly   477 AGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIR 541

  Fly   299 HKEINSIRHVAYAKC---LIWSFNRFLTPVSIFLSLVGFVLMGRF--LTAEVAFLITAYYNVVRT 358
            .|||.::|..||...   .:||...||..:..|.:   :||....  |:.|...:..|.:::::.
  Fly   542 DKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFAT---YVLTSEANQLSVEKVLVSIALFDLMKL 603

  Fly   359 NMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAP 423
            .:|....:.| ..|||.||:.|:.|.|.|.|:   |.|.|.:.:.:            |.||
  Fly   604 PLTILPMLSV-DIAETQVSVNRINKFLNSEEL---DPNSVLHDSSK------------PHPM--- 649

  Fly   424 EKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRV 488
                       ||...:..|   ..:.||..:|::|..|:|||:||..||||||::||.|||:..
  Fly   650 -----------SIENGEFSW---GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEK 700

  Fly   489 ESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILG 553
            .:|.:...|.::|..|:.|:.:.|||.||||||..||:||:.|:..|||..|.::|...|.|.:|
  Fly   701 LAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIG 765

  Fly   554 DRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVTH 616
            ::|.:||||||.||||||:||.||.:|||||||||||:.|.:.:|||.:  :|.|..|..:||||
  Fly   766 EKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTH 830

  Fly   617 QLQFLQQADQIVIMEMGKVKAVGTYESLHKS-GLDFGIVLDDPVNDNEAAED------------- 667
            .:.||.|.|.|.:::||::...||::.|.|: |.....::......||..|:
  Fly   831 GVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTAD 895

  Fly   668 -------------RSRTSSITD---------------------QRRSSVKSVLSHAESCPEDVGE 698
                         .:||.|::|                     :|:.|..||.|.|....:...|
  Fly   896 VPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVE 960

  Fly   699 EQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVA 763
            .:.|..::.|.|.....||..|.::.|.|||.:.::..|| .|......:.:|:.|.  |::.||
  Fly   961 GKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFV-FQAFQIGSNLWLTQWA--NDQNVA 1022

  Fly   764 HNYTTDAKDADFEMHAAYIY--MLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASM- 825
            ::  |..:|....::.|:.:  .::...::::.....|       :|:..:||.:...|.|.|:
  Fly  1023 ND--TGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGF-------QAAKTIHNELLAVIIRGSVC 1078

  Fly   826 YFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVI 890
            .||:..|.|.:||.||.||..|||.||..:.:.:....:....|:||::..|:||...:....:.
  Fly  1079 RFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLY 1143

  Fly   891 YYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYM 955
            |:.:.||:.||..:.|||:.:|||:||||:.::.|.|||||:..|.....|.|...|.:....|.
  Fly  1144 YFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYP 1208

  Fly   956 FISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENT 1020
            .:..:|..|..:::...|.|...:|...:...::...|||:::.|:.:|.|:.|.||.|:::|..
  Fly  1209 SVIANRWLAIRLEMVGNLIILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETN 1273

  Fly  1021 MISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKP 1085
            ::||||:.||.|.:.|.|.|...||...::||::|::||....:||...|  :.||:.:||.|:.
  Fly  1274 IVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGL--DLVLRGVSFNIQG 1336

  Fly  1086 KEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTV 1149
            .||||||||||||||||..|||| :....|.:.||..|...||||.|||:::||||:||||||::
  Fly  1337 GEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSL 1401

  Fly  1150 RHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNR 1214
            |.|||||:..:||.:|.|||...||..|.|:|.||..:|.|||.|.|||||||||||||:||..:
  Fly  1402 RINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTK 1466

  Fly  1215 ILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYEL 1279
            :||:|||||.||.:||.|||.|||.:|:||||||:||||:||:|||:|:|:|.|:::||.:|.||
  Fly  1467 VLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTEL 1531

  Fly  1280 LTADDTNAFQDLVK 1293
            |. :..:||..:.|
  Fly  1532 LD-NPKSAFYSMAK 1544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	470/1364 (34%)
		ABC_membrane	94..360	CDD:294371	80/276 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	96/201 (48%)
		ABC_membrane	736..980	CDD:294371	69/246 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	130/221 (59%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	475/1379 (34%)
		ABC_membrane	338..601	CDD:279056	80/271 (30%)
		ABCC_MRP_domain1	649..848	CDD:213217	97/215 (45%)
		ABC_membrane	988..1260	CDD:279056	78/283 (28%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	130/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.800