DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Sur

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	2018	Identity:	446/2018 - (22%)
Similarity:	731/2018 - (36%)	Gaps:	765/2018 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNASLLRV 81
            :..:|...||:..|....|.|..|..:||.:...|..|.|..:.....:..:.:.:..:.||...
  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSSPSLWYC 290

  Fly    82 LFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLI-------SSFSNPSPTSNGVAYA---YAGGV 136
            ..:...:.|...|::....::...:.|:.:.|::       :..|.|...|.|...|   .:...
  Fly   291 YIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEVANVLLSTSR 355

  Fly   137 ILGS----------------------------------ALKVILMNPYSFAVTHL----GLKIRV 163
            |||:                                  .|..|.....|.|.||:    |::|:.
  Fly   356 ILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHILNMTGIRIKT 420

  Fly   164 GVSSMIYRKCLRLT-------------------------KTDLGEISTGHIIN----LISNDLGR 199
            .:..:||||.|.|.                         |.|....:..|:.|    .||:|:|.
  Fly   421 SLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPNISHDIGS 485

  Fly   200 M------DT-----FIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFG-MTFILLFIPLQMYLGKK 252
            :      ||     |....||.|..|.:..:|.||:|..:||:||.| :..|::..|||.::|..
  Fly   486 ITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNA 550

  Fly   253 ISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIR----------- 306
            :|......|..:|:|::.:.:.:.||:|||:.||:..|.|.:..||.||:..:.
  Fly   551 MSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAV 615

  Fly   307 --HVAYA-------KCLIW-------------------SFNRFLTPVSIFLSLVGFVLMGRFLTA 343
              |:|..       ...:|                   .|.:...|:.||...|..::..|..|.
  Fly   616 LTHIATVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLLIFPITVPIIIAARVSTR 680

  Fly   344 EV-AFL-------------------------ITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQ 382
            .: .||                         :..|....::|||..     |..||..::.||:.
  Fly   681 RLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMR-----TAQAENRLNEKRLA 740

  Fly   383 KLLLSGEVVAKDENVVSNGAE--EDL--------------QEAREKLLVTP-TPMRAPEKPPHNS 430
            :...:.|:......::.|..|  ||:              |:.||.|..|| ..:|.|:......
  Fly   741 QKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYVAIRPPKMRGSVM 805

  Fly   431 EDCVSISELKAK----WTTNS-----PDYTLSGVN--------------LQVHA-------GALV 465
            |..|..|.::|:    |..:|     ||.....:|              :|:|.       |.|.
  Fly   806 ERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQLHVPGIIVPKGKLT 870

  Fly   466 AIVGHTGSGKSSLIQAILGELRVESGEI--EVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRY 528
            .:||..||||:||:.|:|.|:.:.:|.:  ..|.::||.||:|||.:.|:|:|||||:....:||
  Fly   871 IVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKRY 935

  Fly   529 DLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSV 593
            |.|:..|||:.|.||:|..|.:|:|:||.::||||:.||::||::|..|::.::||||:::|:.|
  Fly   936 DFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEV 1000

  Fly   594 ARRLFEECLRGHLR--DKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY--------------- 641
            ...:|:.|:|..|:  ::..||||.||..:::|:.::.::.|:|:|.|:|
  Fly  1001 GEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWN 1065

  Fly   642 -----------------------------ESLHKSGLDFGIVL---------------------- 655
                                         :::.|.||...|.:
  Fly  1066 AIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVA 1130

  Fly   656 ---------DDPV---------------------------------------------------- 659
                     ||.|
  Fly  1131 NMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRR 1195

  Fly   660 ---------NDN--------------------------------------EAAED---------- 667
                     |.|                                      |::.|
  Fly  1196 HTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPE 1260

  Fly   668 ------------------------------------------RSRTSS---ITDQRR-------- 679
                                                      ||.|||   :.|..|
  Fly  1261 PRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLR 1325

  Fly   680 -----------------SSVKSVLSHAESCP-----------------EDVGEEQK---INLQRQ 707
                             |:..|:||.:|..|                 |...||:.   :|:..:
  Fly  1326 RMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSK 1390

  Fly   708 QL-------------------------------------------GRNGL--------------- 714
            :.                                           ||..:
  Fly  1391 ETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGK 1455

  Fly   715 ---GVYVDYFRAGGGFLSFSVVMTFFVCS---QGLASLGDYFLSPW------VSRNEKMVAHNYT 767
               .:|:.|.||.|    ..::..||:.:   |.|....|.:|..|      |:....:|.|...
  Fly  1456 ISDDIYLMYIRAAG----LPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSE 1516

  Fly   768 TDAK-DADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKN 831
            .|.: ...|.|:|| |..:..:::::.|....:...|    |...||:.:.:.|...:::||...
  Fly  1517 QDHEVTYYFRMYAA-ISCVCIIMALVSTPAGQYAGCN----ARRNLHDKLLQTILHKTLHFFQVT 1576

  Fly   832 PAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSF 896
            |.|.|:||||.||..:|:.:......::|..||....|::...:.|..|:..|......|.::.|
  Fly  1577 PLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQKF 1641

  Fly   897 YLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGS----ILEAEFDGYQDMHSSASYMFI 957
            |..::.:::|:|.:|.|||.||.:.::.|::|||||...:    ||....:.     ::.:|..:
  Fly  1642 YRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEA-----NTIAYALL 1701

  Fly   958 STSRAFAYWMDIF------CVLFIAMIT------------LSFFIFPPSSAAD------------ 992
            :||..   |:.:.      |::|:|.:|            ......|.:||:.
  Fly  1702 NTSHR---WLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSP 1763

  Fly   993 ---------VGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEY------------------ 1030
                     |||||...:.:...:.|.|:..|::|....||||:..|
  Fly  1764 SELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADV 1828

  Fly  1031 ---------------------------EEIEP--------------------------------- 1035
                                       :::.|
  Fly  1829 DADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQG 1893

  Fly  1036 -EGPLEATADK-----------------------------------------------------K 1046
             |...||.|||                                                     .
  Fly  1894 HENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVL 1958

  Fly  1047 PHE-------------SWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAG 1098
            |:|             |||::|.|.|..:|||||.  :.::|:.:|:..|...:::||.||||:|
  Fly  1959 PNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEG--QKQNVISNLTLKIPAGQRIGICGRTGSG 2021

  Fly  1099 KSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDD 1162
            ||||..:||. |....|.:.|||.|...:...:||:::|||||:..||:.|:|.||||...:.|.
  Fly  2022 KSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQDL 2086

  Fly  1163 RLWCALEEVELKDVV-ASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVD 1226
            :||..||..:||:.| ..:..||:|.|.:||.|.|.|.|||:||||||||.:..||:||||:.:|
  Fly  2087 QLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLD 2151

  Fly  1227 PQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDL 1291
            ..|::.:.......||..|::|:||||.||:|.||::|:|.||:||.|.|.||...:. :.|:.|
  Fly  2152 SSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG-SVFRGL 2215

  Fly  1292 VKQ 1294
            :::
  Fly  2216 LEK 2218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	444/2003 (22%)
		ABC_membrane	94..360	CDD:294371	84/419 (20%)
		ABCC_MRP_domain1	434..634	CDD:213217	82/233 (35%)
		ABC_membrane	736..980	CDD:294371	68/275 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	101/222 (45%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160