DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCB5

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	1329	Identity:	313/1329 - (23%)
Similarity:	536/1329 - (40%)	Gaps:	327/1329 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GLKIRVGV----SSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQA- 217
            ||.|.:.:    :|::...||.|....|||:|.    ||||..|.:.:|    |:|......|.
Human    42 GLDITLMILGILASLVNGACLPLMPLVLGEMSD----NLISGCLVQTNT----TNYQNCTQSQEK 98

  Fly   218 ----LMVTYLMYQEIGIAA-VFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMR-------- 269
                :.:..|.|..||:|| :||...|.|:|               .||.|..||:|
Human    99 LNEDMTLLTLYYVGIGVAALIFGYIQISLWI---------------ITAARQTKRIRKQFFHSVL 148

  Fly   270 -----------------IMTEII----------------------AGIQVIKMYAWELPF----- 290
                             .||:.|                      .|:.|..:..|:|..
Human   149 AQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLST 213

  Fly   291 -----------EKMVAHARHKE--------------INSIRHVAYAKCLIWSFNRFLTPV----- 325
                       .:||.....||              ::|||.|...:.......|:...:
Human   214 SPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKD 278

  Fly   326 ---------SIFLSLVGFVLMGRF-----------LTAEVAFLITAYYNVVRTNMTAYFSVGVTQ 370
                     .:.|..|.|.:.|.:           |..|..:       .:.|.:..:|||
Human   279 FGIKRTIASKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGY-------TIGTVLAVFFSV---- 332

  Fly   371 TAETLVSIKRVQKLLLSGEVVAKDEN-VVSNGAEEDLQEAREKLLVTPTPMRAPEKP-------- 426
                      :......|..|...|. .::.||...:.:..:|            ||
Human   333 ----------IHSSYCIGAAVPHFETFAIARGAAFHIFQVIDK------------KPSIDNFSTA 375

  Fly   427 ---PHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAIL----- 483
               |.:.|..|....:...:.:......|.|:||::.:|..||:||..|||||:::|.:.
Human   376 GYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDP 440

  Fly   484 --GELRVESGEIEVTGSMSY------ASQEPWLFSGTVRQNILFG------QPMDR-----RRYD 529
              |.:.|:..:|.......|      .||||.||..|:..||.:|      :.|:|     ..||
Human   441 DDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 505

  Fly   530 LVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDS--- 591
            .::.          .|.|..|::|::||.:|||||.||::||::.|:..|.:||:..||:||
Human   506 FIME----------FPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESK 560

  Fly   592 SVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY-ESLHKSGLDFGIVL 655
            |..:...|:..:|    :..|:|.|:|..::.||.||.::.|.:...|.: |.:.|.||.:.:|:
Human   561 SAVQAALEKASKG----RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVM 621

  Fly   656 DDPVNDNEAAEDRSRTSSITDQRRS------SVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGL 714
            .   .|.:.|:::..:.:.:.:|::      ||||:.|......|:..:.::|:|....|.:
Human   622 S---QDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLK--- 680

  Fly   715 GVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVS----RNEKMVAHNYTTDAKDADF 775
                        .|..:.....||....|||:.:..:.|..|    :...|..:|..|..|
Human   681 ------------ILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLK---- 729

  Fly   776 EMHAAYIYMLITVLSIMVTIKRSF---LFFNLAMR-ASIQLHNSMFRGISRASMYFFN--KNPAG 834
              |.|.||.:|.|:..::.....|   ||:..|.. .:::|.:..|:.:....:.:|:  :|..|
Human   730 --HDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTG 792

  Fly   835 SILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIV--NPLFLI----PALAF-GIV-IY 891
            .:....:.|:.|:.....:.|..:.|:....|.::|:..|.  ...|||    |.||. |:: ..
Human   793 GLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETA 857

  Fly   892 YLRSFYLKTSLDVKRL-EASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGY---QDMHSSA 952
            .:..|..|...::|.. :.:|.         :|..:.||.:.......|..::..   |..::|.
Human   858 AMTGFANKDKQELKHAGKIATE---------ALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSK 913

  Fly   953 SYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAEL 1017
            ....|.:..||::               :|..|..::....|..:.||..:|....:.| .:|..
Human   914 KAQIIGSCYAFSH---------------AFIYFAYAAGFRFGAYLIQAGRMTPEGMFIV-FTAIA 962

  Fly  1018 ENTMISVERMI---EYEEIEP-EGPLEATADKKPH-ESWPEQGK--------IEFVELSLRYEPY 1069
            ...|...|.::   ||.:.:. ...|.|..:|||: :|..::||        :||.|:|..| |.
Human   963 YGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFY-PC 1026

  Fly  1070 LKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN--DGSVRIDDKDTNDMGLHDLR 1132
            .....:|:.||..|:..:.|..||.:|.|||:.:..|.|| |:  .|.|..|..|..::.:..||
Human  1027 RPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRL-YDPVQGQVLFDGVDAKELNVQWLR 1090

  Fly  1133 SKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLE-------TKITE 1190
            |:|:|:|||||||:.::..|:    .|.|:.....|:|::.....|::.:.:|       |::..
Human  1091 SQIAIVPQEPVLFNCSIAENI----AYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 1151

  Fly  1191 GGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHT 1255
            .|:..|.||:|.:.:|||:|:..:||::||||:.:|..::.::|..:.......|.|.|.|||..
Human  1152 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSA 1216

  Fly  1256 IMDSDRVLVMDAGRVVEFGTPYELLTADD 1284
            |.::|.::|:..|::.|.||..|||...|
Human  1217 IQNADLIVVLHNGKIKEQGTHQELLRNRD 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	311/1324 (23%)
		ABC_membrane	94..360	CDD:294371	60/313 (19%)
		ABCC_MRP_domain1	434..634	CDD:213217	68/226 (30%)
		ABC_membrane	736..980	CDD:294371	53/265 (20%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	76/237 (32%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PTZ00265	8..1251	CDD:240339	313/1329 (24%)
		ABC_membrane	52..333	CDD:279056	60/324 (19%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	75/253 (30%)
		ABC_membrane	696..962	CDD:279056	59/296 (20%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	79/236 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000