DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1382	Identity:	451/1382 - (32%)
Similarity:	728/1382 - (52%)	Gaps:	135/1382 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVT-LGAKDLYRALKEHRAESLGNKLCSS 64
            ::.|:.....::|.:.:..||.::..:..|...:..|.: |..:|::.......:|:...:|...
Zfish    49 LKPFRITHKHQHPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVWGLSCHEASETNCQRLEWL 113

  Fly    65 WANELE-TNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILT-----VQPMFLMKLISSFSNPSP 123
            |..||: ..|..|||.||.:|     |....:::....:::|     |.|..|::.:..||..|.
Zfish   114 WHEELKRRGKDGASLSRVFWR-----FCQTRMLVAIFSLLITMVAGFVGPALLIRALLEFSQCSE 173

  Fly   124 TSNGVAYAYAGGVILGSALKVILMNPYSFAVT-----HLGLKIRVGVSSMIYRKCLRLTKTDLGE 183
            .......|...|:.|     :.|...:|.|..     ....::|....:..::|.|||..|.  :
Zfish   174 VKLLYGLALVAGIFL-----MELTRSWSLAFMWAINYRTAARLRGAALTFAFQKILRLRSTK--D 231

  Fly   184 ISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALM-VTYLMYQEIGIAAVFGMTFILLFIPLQM 247
            :|:|.::|:.::|..|:...:.....|...||..:: :||..| .:|..|:.|....::|.|..|
Zfish   232 VSSGELVNICASDGQRLYEAVSVGCLLAGGPLVGMLGLTYTTY-FLGPTALVGSAIFIIFYPTMM 295

  Fly   248 YLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAK 312
            ...:..:..|.|....:|:|:|:|.||:..::.||||.||.||...:...|.:|   .|::.:|.
Zfish   296 LASRMTAYFRKKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQKVRSEE---RRNLEWAG 357

  Fly   313 CLIWSFNRFLTPVSIFL-SLVGFVL---MGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTA- 372
            | :.|....:.||.:.: |:..|.|   :|..|||..||.:.|.:|    :||  |::.||..|
Zfish   358 C-VQSLTLGVAPVVVVIASVCTFTLHMALGYDLTAAQAFTVVAVFN----SMT--FALKVTPLAV 415

  Fly   373 ----ETLVSIKRVQKLLLSGEVVAKDENVVSNGAEE-----DLQEA------------------- 409
                |..|::||.|||.:     .:|..::|...|:     :.::|
Zfish   416 RALSEGSVAVKRFQKLFM-----MEDRELISVKTEDPYNVVEFKDATLAWEKTCGSQTKKSRTQL 475

  Fly   410 ----------REKL---LVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDY--------TLS 453
                      ||||   ::|.......|:|  |:|..::..|.::..:|.|...        ||.
Zfish   476 KRGGMKRVLRREKLSLYIITEENKGKIEEP--NAEHLLTHMEQESPQSTISSTQSIRPPLHKTLH 538

  Fly   454 GVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNIL 518
            .::|.:..|:||.:.|..|||||||:.|:||::.:..|.:.|.|..:|.:|:.|:.:.::|:|||
Zfish   539 RIDLCIQKGSLVGVCGGVGSGKSSLLSALLGQMTLLGGSVSVNGGFAYVAQQAWILNDSLRENIL 603

  Fly   519 FGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLD 583
            ||:..:..:|:.|:..|.|..|...||..|.|.:|:|||:|||||:.|:||||::|.:..|.|||
Zfish   604 FGKKYNEEKYNAVLEACCLFPDIIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPILLLD 668

  Fly   584 DPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSG 648
            |||||||:.|..|||...:|...:.|.||.||||||:|.:.|.:|:|:.|::...||:..|.:.|
Zfish   669 DPLSAVDARVGSRLFHSAIRPAAKGKTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTHTQLMEKG 733

  Fly   649 LDFGIVLDDPVNDN---------EAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKIN- 703
            .|:..:.:....:|         |.||..|...::             |..:.|:...|.:|.:
Zfish   734 RDYAALFNSVQQENLVRKNLKNKEKAEKESSPQTL-------------HVSNPPKPDTESKKTDQ 785

  Fly   704 -LQRQQLGRNGLG--VYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWV---SRNEKMV 762
             :|.::.|...:.  ||..|.:|.||.|:|.|.:..|:.:.|..:..:::||.|:   |.|..::
Zfish   786 LMQAEEKGSGAVAWPVYAAYIKAAGGPLAFIVTILLFLFTTGSIAFSNWWLSYWIRQGSGNSSLL 850

  Fly   763 AHNYTTDAKDADFEMHAAY---IYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRAS 824
            ..|.|.::.......|..|   :|:|....::.:...|..:|....:||:..||:.:|:.:..:.
Zfish   851 LGNETAESDSMRLNPHIQYYSRVYVLSMGAALFLKTIRGLVFVKCTVRAASVLHDKLFKTLLLSP 915

  Fly   825 MYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIV 889
            |.||:..|.|.|||||||||.:||..|......::|:..|....:.|:..|.|.||...:..|..
Zfish   916 MRFFDTTPLGRILNRFSKDMDEVDVRLAMQAEMLLQNVTLVLFCLGVVGAVFPWFLFSIIPLGAF 980

  Fly   890 IYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASY 954
            ::.:.........::||||..::||..||..:||.|||||.|:|.|:.....:....|.:.:..:
Zfish   981 LFIVNRISRVLIRELKRLENISQSPFTSHITSSLQGLSTIYAYGRGADFIHRYQALLDTNQACQF 1045

  Fly   955 MFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPS-SAADVGLAITQAMGLTGTVQWTVRQSAELE 1018
            :|....|..|..:|:..:..|..:.|...:.... |.|..|||::.|:.|||..|:|||..:|.|
Zfish  1046 LFSCAMRWLAVRLDLISISLITTVALLIVLMHGHISPAYAGLALSYAVQLTGLFQFTVRLLSETE 1110

  Fly  1019 NTMISVERMIEY-EEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFV 1082
            ....||||:..| :.:|.|||.:.|.......|||.:|:|.|.::.:||...|  ..|||:|.|.
Zfish  1111 ARFTSVERINHYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYRDGL--PLVLKNLCFS 1173

  Fly  1083 IKPKEKVGIVGRTGAGKSSLINALFRLS-YNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFS 1146
            |.|:|.:|||||||:|||||..|||||: .:.||:.||..:...:||.|||||:|:||||||||.
Zfish  1174 ILPEETIGIVGRTGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSVIPQEPVLFI 1238

  Fly  1147 GTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILR 1211
            ||||.||||:|:|:|.::|.|||:..:||:|:.:...|.:::|:.|.|||||:|||:|:|||:||
Zfish  1239 GTVRSNLDPWDQYTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQLLCVARALLR 1303

  Fly  1212 DNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTP 1276
            .::||::|||||.:|.:||.|||.|||:.|..||.|.:||||:|::..:|::|:|.|:::||.||
Zfish  1304 HSKILLLDEATAAIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQGQILEFDTP 1368

  Fly  1277 YELLTADDTNAFQDLVK 1293
            ..||| |:.:.|..:::
Zfish  1369 SNLLT-DENSRFHAMME 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	446/1357 (33%)
		ABC_membrane	94..360	CDD:294371	71/280 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/207 (41%)
		ABC_membrane	736..980	CDD:294371	69/249 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	117/221 (53%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	450/1370 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585987
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760