DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc5

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001182542.1	Gene:	abcc5 / 336147	ZFINID:	ZDB-GENE-050517-17	Length:	1426	Species:	Danio rerio

Alignment Length:	1368	Identity:	454/1368 - (33%)
Similarity:	718/1368 - (52%)	Gaps:	139/1368 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ENPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKK 74
            ::|.:.:.:||.::| |.|....:..:|..|..:|::...:....|....:|...|..|:.:...
Zfish    93 QHPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQFESCEINRRRLAGLWEEEIRSRGN 157

  Fly    75 NASLLRVLFRVFGRYFVFLGLVLFCLEVILTV---QPMFLMKLISSFSNPSPTSNGVAYAYAGGV 136
            :|||.||::. |.|..:.|.::  ||.|....   .|.|::..:..::..|...    ..|...:
Zfish   158 DASLRRVVWH-FCRTRLLLSIL--CLMVTQLAGFSSPAFVVWRLLEYTQRSEPD----LPYGLLL 215

  Fly   137 ILGSALKVILMNPYSFAVT-----HLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISND 196
            :|| .|...|:..:|.|:|     ..|.::|..:.:|.:.|.|||  ..|.|.|.|.:||:.|.|
Zfish   216 VLG-LLATELIRSWSHALTWALNYRTGTRLRGAILTMAFHKILRL--RSLREKSMGELINMCSGD 277

  Fly   197 LGRMDTFIQFTHYLWLAPLQALM-VTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKT 260
            ..||.........|...||.|:: :.|.:: .:|..::.|....:||.|..|:..:..:..|.|.
Zfish   278 GQRMFEAAAVGSLLAGGPLVAVLGMAYNLF-VLGPTSLLGSAVFILFYPTMMFSSRLTAYFRRKG 341

  Fly   261 AIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPV 325
            ...:|:|::.|.||:..|:.||||||...|.:.|...|.:|...:....|.:    |....:.|:
Zfish   342 VAVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQILERTGYFQ----SITVGVAPI 402

  Fly   326 SIFLSLVG----FVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVT-----QTAETLVSIKRV 381
            .:.::.|.    .:|:|..|||..||.:...:|.    ||  |::.||     ..:|..|:|.|.
Zfish   403 VVVIASVATFSTHMLLGYDLTAAQAFTVVTVFNA----MT--FALKVTPFSVKSLSEASVAIDRF 461

  Fly   382 QKLLLSGEV-----------VAKDENVVSNGAEEDLQEAREKLLVTPTPMRAP------------ 423
            :.|||..||           ||.:.:..|...|.....|:      |:|...|
Zfish   462 KSLLLMAEVKMIRELPRNPSVAVEMSGASLAWETGGHSAQ------PSPRGTPHVGTRGCRKKRR 520

  Fly   424 --EKPPHNS---EDCVS--ISELKAKWTTNSPDY-------------TLSGVNLQVHAGALVAIV 468
              :.|.|::   |:...  ::::..:..::..|.             ||..::|.:..|.||.:.
Zfish   521 QRDVPKHHAILEEETHGQLLNDVSGEMASSPKDQTLHVPTISQRLQRTLHCIDLSIQKGKLVGVC 585

  Fly   469 GHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVR 533
            |..||||:|||.||||::.:..|.:.|.|..:|.:|:.|:.:.:.|.|||||:.|:..||..::.
Zfish   586 GSVGSGKTSLISAILGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERYQAILS 650

  Fly   534 KCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLF 598
            .|.|..|..:||..|.|.:|:|||:|||||:.||||||::|.:..||:|||||||:|:.|...:|
Zfish   651 ACCLRPDLAMLPSGDLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHVGNHIF 715

  Fly   599 EECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDD------ 657
            ...::..||.|.||.||||||:|...|.:::|..|.:...|::|.|.....|:..:.::
Zfish   716 NNAIKKQLRGKTVIFVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMFNNLQLGET 780

  Fly   658 PVNDNEAAEDRSRTS---SITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVD 719
            |:  .|....:|.:|   .:...:..|||...|..:      |:.|.:.::.:..|.....||..
Zfish   781 PI--IEVPNKKSGSSLKKPLEKSKAGSVKKEKSTTQ------GDGQLMQVEERGKGSVPWAVYKV 837

  Fly   720 YFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWV---SRNEKMVAHN---YTTDAKDADFEMH 778
            |.:|.||:..|..::..|:.:.|..:..:::|..|:   |.|..:...|   .:...:|.....|
Zfish   838 YIQALGGWPVFLFILALFILNVGSTAFSNWWLCYWIKQGSGNTTVQVGNSSVLSESMRDNPLMQH 902

  Fly   779 AAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKD 843
            .|.:|.:...:.:::.:.|..:|....:|||.:||:.:|:.|.|:.|.||:..|...||||||||
Zfish   903 YAAVYTMSMGVMLLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPTARILNRFSKD 967

  Fly   844 MGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLI---PALAFGIVIYYLRSFYLKTSLDVK 905
            |.:||..||.......|:.:|....:.||..|.|.||:   |.:....|::.:...:::   ::|
Zfish   968 MDEVDTRLPFQAEMFTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTVLHVVSRVFIR---ELK 1029

  Fly   906 RLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEF-DGYQ---DMHSSASYMFISTSRAFAYW 966
            ||:..|:||..||.|:|:.||:|:.|:|.    |.|| ..||   |.:.:..|:|....|..|..
Zfish  1030 RLDNVTQSPFLSHIASSIQGLTTVHAYGK----EDEFLHRYQELLDQNQAPFYLFSCAMRWLAVR 1090

  Fly   967 MDIFCVLFIA----MITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERM 1027
            :|:..|..|:    ||.|.....||:.|   ||||:.|:.|||..|:|||.::|.|....||||:
Zfish  1091 LDVISVALISITALMIVLMHGQIPPAYA---GLAISYAVQLTGLFQFTVRLASETEARFTSVERI 1152

  Fly  1028 IEY-EEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGI 1091
            ..| :.:..|.|.. ..:|.|...||::|:|.|.:..::|...|  ..:||..||.::||||:||
Zfish  1153 HHYIKSLSLEAPAR-VKNKAPPSDWPQEGEIVFDQTEMKYRDNL--PLILKKASFTVRPKEKIGI 1214

  Fly  1092 VGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDP 1155
            |||||:|||||...|:|| ....||::||..:..|:||.|:|||:|||||||||||||||.||||
Zfish  1215 VGRTGSGKSSLGVVLYRLVEPCGGSIKIDGVNICDIGLADVRSKLSIIPQEPVLFSGTVRSNLDP 1279

  Fly  1156 FDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDE 1220
            |.:||:.::|.|||...:|:.|:.:...||:::.|.|.|||||:|||:|:||.:||..:||::||
Zfish  1280 FSQYSEAQIWDALERTHMKECVSQLPLKLESEVVENGENFSVGERQLLCVARVLLRQCKILILDE 1344

  Fly  1221 ATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDT 1285
            |||.:..:||.|||.||||.|::||.||:|||:||::..||::|::.|:||||..|.:|| |::.
Zfish  1345 ATAAMGTETDCLIQETIRNAFQDCTTLTIAHRVHTVLSCDRIMVLNQGQVVEFDEPSKLL-ANEN 1408

  Fly  1286 NAF 1288
            :.|
Zfish  1409 SRF 1411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	451/1358 (33%)
		ABC_membrane	94..360	CDD:294371	72/278 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	83/214 (39%)
		ABC_membrane	736..980	CDD:294371	78/260 (30%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	118/221 (53%)
abcc5	NP_001182542.1	intraplasmic N-terminal	1..59
		transmembrane domain 1	59..149		11/55 (20%)
		CFTR_protein	95..1419	CDD:273530	454/1366 (33%)
		ABC_membrane	177..441	CDD:294371	75/283 (27%)
		nucleotide binding domain 1	188..248		13/64 (20%)
		transmembrane domain 2	279..379		29/100 (29%)
		nucleotide binding domain 2	403..450		14/52 (27%)
		ABCC_MRP_domain1	552..751	CDD:213217	83/198 (42%)
		ABC_membrane	851..1132	CDD:294371	90/290 (31%)
		ABCC_MRP_domain2	1180..1400	CDD:213211	118/221 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660