DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1349	Identity:	432/1349 - (32%)
Similarity:	689/1349 - (51%)	Gaps:	152/1349 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SALSFWYTIPTFIKGQKVTL-GAKDLYRALKEHRAESLGNKLCSSWANELETNKKNASLLRVLFR 84
            |..|:.:..|...:|.:..| ..:|..|..:......|.....:.|       |:.|.|.|.|:.
  Rat   223 SRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLARAFQAHW-------KEGAQLWRALYG 280

  Fly    85 VFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSF--SNPSPTSNGVAYAYAGGVILGSALKVILM 147
            .||..::.||| |..:..:|......|:.|:..|  ....|.|:|:.|..  |:..||.:..:|.
  Rat   281 AFGCCYIALGL-LKMVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYVL--GLASGSVISAVLQ 342

  Fly   148 NPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWL 212
            |.|.:.|..:.|:.||.|.|::|||.|:|..:   ...||.::||:..|..|:..|....|..|.
  Rat   343 NQYGYEVRKVTLQARVAVLSILYRKTLKLGPS---RPPTGEVLNLLGTDSERLLNFAGSFHEAWG 404

  Fly   213 APLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAG 277
            .|||..:..||:|:::|:|.:.|:...||.:|:...:..:|.....:.....|.|:::|||:::|
  Rat   405 LPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMANNQEMLRHKDARVKLMTELLSG 469

  Fly   278 IQVIKMYAWELPFEKMVAHARHKEINSIRHVAY--AKCL-IWSFNRFLTPVSIFLSLVGFVLMGR 339
            |:|:|.:.||......|...|.:|:..:|.:.|  |.|: :|:....:..:.||::   :||:|.
  Rat   470 IRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVICIVIFIT---YVLLGH 531

  Fly   340 FLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEE 404
            .|||...|...|..:::...:..:..| :....|:.||:.|:|:.|
  Rat   532 QLTATKVFTALALVHMLILPLNNFPWV-INGLLESKVSLDRIQRFL------------------- 576

  Fly   405 DLQEAREKLLVTPTPMRAPE-----KPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGAL 464
            ||            |..:||     .||......:.:.|....|............:|||..|.|
  Rat   577 DL------------PSYSPEAYYSPDPPTEPSTVLELHEALFSWDPTGTSQKTFISHLQVKKGML 629

  Fly   465 VAIVGHTGSGKSSLIQAILGELRVESGEIEVTG---SMSYASQEPWLFSGTVRQNILFGQPMDRR 526
            |.|||..|.|||||:.||.|||....|.:.|:.   ....|:||||:...|:|.|:|||:..|.:
  Rat   630 VGIVGKVGCGKSSLLAAITGELHRLCGWVAVSDLSKGFGLATQEPWIQCATIRDNVLFGKTFDAQ 694

  Fly   527 RYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDS 591
            .|..|:..|||..|..:||..|:|.:|::|.:|||||:|||:|||:||::.::|||||||:|||:
  Rat   695 LYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYLLDDPLAAVDA 759

  Fly   592 SVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLD 656
            .||..|...|:.|.|.....:|.||:.::|::||.:::||.|::...|....:      ..:|..
  Rat   760 DVANHLLHRCILGVLGHTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEI------LPLVQA 818

  Fly   657 DP--VNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNG---LGV 716
            .|  :.|.|...|..::.|:.:..:::.:.          ||.:.....|.:::....|   |.|
  Rat   819 APTALADKEQVTDSGQSPSVHNLEKTTEEL----------DVAQNTSGRLVQEESKSEGAVALHV 873

  Fly   717 YVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSR------------------------ 757
            |..|:||.|..|:.:::::..: .|...:..|::|:.|:|:
  Rat   874 YRAYWRAMGSGLATAILISLLL-MQATRNGADWWLAHWLSQLKAGRNSSEERPASSSPRSMGFFS 937

  Fly   758 ---------NEKMVAHNYTTD-AKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQL 812
                     |..:..|..|:: :.|..|.:   .:|..|..::.:.|:.|:.||...|::|:..|
  Rat   938 PRLLLFSPGNLYIPLHKATSNGSSDVHFYL---TVYATIAGVNSLCTLLRAVLFAAGALQAAASL 999

  Fly   813 HNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP 877
            |:.:...:..|.:.|::..|:|.:|||||.|:..||:.||.::..::.:.:...|.:.|:....|
  Rat  1000 HHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLP 1064

  Fly   878 --LFLIPALAFGIVIYY-LRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILE 939
              |.|:|.|:|   ||| ::..|..:..:::||.:.|.||:|||.|.:|.||..:||.||....|
  Rat  1065 WLLLLLPPLSF---IYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRAAGATYRFE 1126

  Fly   940 AEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLF----------IAMITLSFFIFPPSSAADVG 994
            .|.....:::....:    .|.|...|:||...|.          ||::.....:..|..   ||
  Rat  1127 EENQRLLELNQRCQF----ASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGL---VG 1184

  Fly   995 LAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHE--SWPEQGKI 1057
            |.::.|:.|||.:...|....:.|..|:||||:.||....|:.| .....:.||:  ||..||.:
  Rat  1185 LVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEP-HGQPPQSPHQRVSWLTQGSV 1248

  Fly  1058 EFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDK 1121
            ||.::.|.|.|.|  .:.|..::|.::|.||:|||||||:|||||...||| |..:.|.|.:|..
  Rat  1249 EFQDVVLVYRPGL--PNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDGV 1311

  Fly  1122 DTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLET 1186
            ||:.:.|.:|||::::|||||.|||||||.||||...:.|..||.|||:..|.:|..::. ||:.
  Rat  1312 DTSQLELAELRSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHLSEVAMAIG-GLDG 1375

  Fly  1187 KITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAH 1251
            ::.|.|.:.|:|||||:|||||:|.|.:||.:|||||:||.:||.|:|.||..:|...||||:||
  Rat  1376 ELGERGRDLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICRRFANKTVLTIAH 1440

  Fly  1252 RLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATY 1300
            ||:||::||||||:.||||||..:| ..|.....:.|:.|::.:.|..:
  Rat  1441 RLNTILNSDRVLVLQAGRVVELDSP-SALRNQPHSLFRQLLQSSQQGAH 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	428/1328 (32%)
		ABC_membrane	94..360	CDD:294371	79/270 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/202 (42%)
		ABC_membrane	736..980	CDD:294371	72/290 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	116/221 (52%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	431/1344 (32%)
		ABC_membrane	290..552	CDD:294371	79/270 (29%)
		ABCC_MRP_domain1	599..802	CDD:213217	85/202 (42%)
		ABC_membrane	957..1190	CDD:294371	68/245 (28%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	25/75 (33%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	116/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345111
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650