DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc5

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_038818.2	Gene:	Abcc5 / 27416	MGIID:	1351644	Length:	1436	Species:	Mus musculus

Alignment Length:	1387	Identity:	470/1387 - (33%)
Similarity:	732/1387 - (52%)	Gaps:	151/1387 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSFKNEDLPENPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSS 64
            ::.|:.....::|.:.:.:||.::| |.:....:..:|..|..:|::...|...::....:|...
Mouse    88 LKPFRTTTKHQHPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKYESSDVNSRRLERL 152

  Fly    65 WANEL-ETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTV---QPMFLMKLISSFSNPSPTS 125
            |..|| |.....|||.||:: :|.|..:.|.:|  ||.:....   .|.|::|.:..::  ..|.
Mouse   153 WQEELNEVGPDAASLRRVVW-IFCRTRLILSIV--CLMITQLAGFSGPAFVVKHLLEYT--QATE 212

  Fly   126 NGVAYAYAGGVILGSALKVILMNPYSFAVT-----HLGLKIRVGVSSMIYRKCLRLTKTDLGEIS 185
            :.:.|:..  ::||..|..::.: :|.|:|     ..|:::|..:.:|.::|.|:|  .::.|.|
Mouse   213 SNLQYSLL--LVLGLLLTEVVRS-WSLALTWALNYRTGVRLRGAILTMAFKKILKL--KNIKEKS 272

  Fly   186 TGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEI--GIAAVFGMTFILLFIPLQMY 248
            .|.:||:.|||..||.........|...|:.|::  .::|..|  |.....|....:||.|..|:
Mouse   273 LGELINICSNDGQRMFEAAAVGSLLAGGPVVAIL--GMIYNVIILGPTGFLGSAVFILFYPAMMF 335

  Fly   249 LGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKC 313
            :.:..:..|.|....:|.|::.|.|::..|:.||||||...|.:.|...|.:|...:....|.:
Mouse   336 VSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKAGYFQ- 399

  Fly   314 LIWSFNRFLTPVSIFL-SLVGF---VLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVT----- 369
               |....:.|:.:.: |:|.|   :.:|..|||..||.:...:|    :||  |::.||
Mouse   400 ---SITVGVAPIVVVIASVVTFSVHMTLGFHLTAAQAFTVVTVFN----SMT--FALKVTPFSVK 455

  Fly   370 QTAETLVSIKRVQKLLLSGEV---------------------------------------VAKDE 395
            ..:|..|::.|.:.|.|..||                                       :.||:
Mouse   456 SLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDK 520

  Fly   396 NVVSNGAEED-----------LQEAREKLLVTPTPMRAPEKPPHNSEDCVSI--SELKAKWTTNS 447
            .......|:.           |.|.:..||     :.:.|:|....|:...|  ..|:.:
Mouse   521 RATRGKKEKSRQLQHTEHQAVLAEQKGHLL-----LDSDERPSPEEEEGKQIHTGSLRLQ----- 575

  Fly   448 PDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGT 512
              .||..::|::..|.||.|.|..||||:||:.||||::.:..|.|.|:|:.:|.:|:.|:.:.|
Mouse   576 --RTLYNIDLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQQAWILNAT 638

  Fly   513 VRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDA 577
            :|.|||||:..|..||:.|:..|.|..|..:||..|.|.:|:|||:|||||:.||||||::|.|.
Mouse   639 LRDNILFGKEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDR 703

  Fly   578 SIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYE 642
            |||:|||||||:|:.|...:|...:|..|:.|.|:.||||||:|...|:::.|:.|.:...||:|
Mouse   704 SIYILDDPLSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHE 768

  Fly   643 SLHKSGLDFGIVLDD-------PVNDNEAAE-DRSRTSSITDQRRSSV---KSVLSHAESCPEDV 696
            .|.....|:..:.::       ||..|...| ..|:.|.....:..||   |:|.|.
Mouse   769 ELMNLNGDYATIFNNLLLGETPPVEINSKKEATGSQKSQDKGPKPGSVKKEKAVKSE-------- 825

  Fly   697 GEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWV---SRN 758
             |.|.:.::.:..|.....||..|.:|.||.|:|.|:|..|:.:.|..:...::||.|:   |.|
Mouse   826 -EGQLVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFSTWWLSYWIKQGSGN 889

  Fly   759 EKMVAHN--YTTDA-KDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGI 820
            ..:...|  :.:|: ||..|..:.|.||.|...:.:::...|..:|....:|||.:||:.:||.|
Mouse   890 STVYQGNRSFVSDSMKDNPFMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRI 954

  Fly   821 SRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLI---P 882
            .|:.|.||:..|.|.|||||||||.:||..||......||:.:|....:.:||.|.|.||:   |
Mouse   955 LRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGP 1019

  Fly   883 ALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQD 947
            .|....:::.:....::   ::|||:..|:||..||..:|:.||:||.|:.........:....|
Mouse  1020 LLILFSLLHIVSRVLIR---ELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQELLD 1081

  Fly   948 MHSSASYMFISTSRAFAYWMDIFCVLFIA----MITLSFFIFPPSSAADVGLAITQAMGLTGTVQ 1008
            .:.:..::|....|..|..:|:..:..|.    ||.|.....|   :|..||||:.|:.|||..|
Mouse  1082 DNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIP---SAYAGLAISYAVQLTGLFQ 1143

  Fly  1009 WTVRQSAELENTMISVERMIEY-EEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKS 1072
            :|||.::|.|....||||:..| :.:..|.|........||: ||::|::.|....:||...|
Mouse  1144 FTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPPHD-WPQEGEVTFENAEMRYRENL-- 1205

  Fly  1073 ESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKIS 1136
            ..|||.:||.||||||:|||||||:|||||..||||| ..:.|.::||....:|:||.|||||::
Mouse  1206 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLADLRSKLA 1270

  Fly  1137 IIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQ 1201
            ||||||||||||||.|||||::|::|::|.|||...:|:.:|.:...||:::.|.|.|||||:||
Mouse  1271 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1335

  Fly  1202 LVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMD 1266
            |:|:|||:||..:||::|||||.:|.:||.|||.|||..|.:||:||:||||||::.|||::|:.
Mouse  1336 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1400

  Fly  1267 AGRVVEFGTPYELLTADDTNAF 1288
            .|:||||.||..||:.|.:..:
Mouse  1401 QGQVVEFDTPSVLLSNDSSRFY 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	467/1367 (34%)
		ABC_membrane	94..360	CDD:294371	71/279 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/201 (44%)
		ABC_membrane	736..980	CDD:294371	78/256 (30%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	125/221 (57%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		PLN03130	100..1424	CDD:215595	469/1375 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..569		11/72 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.610