Protein Alignment CG31792 and Abcc8

DIOPT Version :10

• Sequence 1: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_037171.2
• Gene: Abcc8 / 25559
• RGDID: 3786
• Length: 1582
• Species: Rattus norvegicus
• Alignment Length: 1413
• Identity: 427/1413 - (30%)
• Similarity: 703/1413 - (49%)
• Gaps: 193/1413 - (13%)

  Fly    18 NIFSALSFWYTIPTFIK-GQKVTLGAKDLYRALKEHRAESLGNKLCSSW----ANELETNKKNAS 77
            |:.|..::|: :..||| ..|..:..:.:.:.....||.:...:||.::    ..:.::.:...:
  Rat   223 NLLSKGTYWW-MNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQGARA 286

  Fly    78 LLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFS------NPSPTSNGVAY------ 130
            :.|.|...|||..|.........:::....|:.:..::....      .|.....||.:
  Rat   287 IWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEF 351

  Fly   131 ---AYAGGVILGSAL---KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDL--GEISTG 187
               ||...|:|..||   :..|...|..|: ..|:.:|..:.:.||.|.:.|:.::|  ||::.|
  Rat   352 LGNAYVLAVLLFLALLLQRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAG 415

  Fly   188 HIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKK 252
            .|.||::.|..::..|......||..|:|.::...|:|..:|::|:.|...|:|..|:|.::..|
  Rat   416 QICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480

  Fly   253 ISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWS 317
            :|..:..|...|::|::...|::.||:::|:||||..|...|...|.||:.|:|..|....:...
  Rat   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIF 545

  Fly   318 FNRFLTPVSIFLSLVGFVLMGR--FLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKR 380
            .|..:...::.::.||.|...:  ..:..|||...:.::::.|.:....|| |..|.:.|||:::
  Rat   546 MNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSV-VRSTVKALVSVQK 609

  Fly   381 VQKLLLSGEV---------------VAKDENV---VSNGAEEDLQEAREKLLVTPTPMRAPEKPP 427
            :.:.|.|.|:               ..|.:.|   |.|......:|.|:  |:.|.....|....
  Rat   610 LSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRD--LLGPLQRLTPSTDG 672

  Fly   428 HNSEDCVSISELKAKWTTNSPD--YTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVES 490
            .....||.|......||   ||  .|||.:.:::..|.|..|||..|.|||||:.|.|||::..|
  Rat   673 DADNFCVQIIGGFFTWT---PDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVS 734

  Fly   491 GEI---------------------------EVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRY 528
            |.:                           ...|.::||||:|||.:.||.:||.|..|.:::||
  Rat   735 GAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRY 799

  Fly   529 DLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSV 593
            .:|:..|:|:.|.::||..|:|.:|:||.:|||||:.|||:||::|:..::..||||.||:|..:
  Rat   800 KMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHL 864

  Fly   594 ARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDF----- 651
            :..|.:..:...|||  :.|:||||:||:|..||.|:.|:.|.::..||.:...:|....
  Rat   865 SDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWK 929

  Fly   652 -----------------------------------GIVLDDPVNDNEAAEDRSRTSSITDQRRSS 681
                                               |::||:...:.||||         .:...:
  Rat   930 TLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAE---------SEEDDN 985

  Fly   682 VKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFS--VVMTFFVCSQGLA 744
            :.|||......|                           :||...:||.:  ::::..|.||.|.
  Rat   986 LSSVLHQRAKIP---------------------------WRACTKYLSSAGILLLSLLVFSQLLK 1023

  Fly   745 SLG----DYFLSPWVSRNEKMV----AHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLF 801
            .:.    ||:|:.|.  :..:|    |.|.:...:.|..:...|.::.::..|.|.:.:..|...
  Rat  1024 HMVLVAIDYWLAKWT--DSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTV 1086

  Fly   802 FNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFG 866
            ....::.:.:||.|:...|..|.|.||...|.||||||||.|...:|:.:|:.:..:.:..||..
  Rat  1087 EWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCV 1151

  Fly   867 GNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRA 931
            ..:.||:.|.|:||:..|...:|.|:::.::...|.|:::|:.:|:.|:.||||.::.||:||||
  Rat  1152 SALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRA 1216

  Fly   932 FGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI------FCVLFIAMIT-LSFFIFPPSS 989
            |...:..:.:...|.|.::.||....:.:|    |:::      .||:.||..| :|..:....|
  Rat  1217 FRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMEYIGACVVLIAAATSISNSLHRELS 1277

  Fly   990 AADVGLAITQAMGLTGTVQWTVRQSAELENTMISVER---MIEYEEIEPEGPLEATADKKPHESW 1051
            |..|||.:|.|:.::..:.|.||..|::|..:.:|:|   :::.|....||.|..:...|   :|
  Rat  1278 AGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPK---NW 1339

  Fly  1052 PEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGS 1115
            |:||||:...||:||:..||  .|||.::.:|.|.:|:||.||||:||||...|.||: ...:|.
  Rat  1340 PDQGKIQIQNLSVRYDSSLK--PVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGR 1402

  Fly  1116 VRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASV 1180
            :.||..|...:.||.|||::|||.|:|||||||:|.||||..:.||..||.|||..:||.||.::
  Rat  1403 IIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKAL 1467

  Fly  1181 ATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECT 1245
            ..||:..|||||.|||.|||||.|||||.:|...|.:||||||::|..|:.::|..:...|.:.|
  Rat  1468 PGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRT 1532

  Fly  1246 VLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVK 1293
            |:|:|||:|||:.:|.|:|:..|.::||..|.:||:..| :.|...|:
  Rat  1533 VVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKD-SVFASFVR 1579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	427/1413 (30%)
Abcc8	NP_037171.2	MRP_assoc_pro	224..1579	CDD:188098	425/1410 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..768		0/26 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	939..962		0/22 (0%)