DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abc4

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1312	Identity:	394/1312 - (30%)
Similarity:	634/1312 - (48%)	Gaps:	131/1312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FKNEDLPENPRERSNIFS-ALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWAN 67
            |..::...:..:..::|: |.|:.|..|..:..::..:...|. ..:.::..    ||   :|..
pombe   218 FPEDNYQPSAEQVCSMFNFACSYGYLNPLVLTAKRRVVEVDDT-PVIPDYDK----NK---AWTY 274

  Fly    68 ELETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTS-NGVAYA 131
            ..| ..|..||...:.::|.|..:.:|:..|.:.|...:.|:.|.:|:....:||.:| |.:.:.
pombe   275 RFE-RMKTPSLFITIHKIFWRQILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSSSVNPLVWI 338

  Fly   132 YAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCL--RLTKTDLGEISTGHIINLIS 194
            ..  ::.|..|..:....|.|..|....:....:...||.|.:  |..:...|:...|...||||
pombe   339 VL--LLTGPFLTSLFTQFYLFMSTRYLARSYTTLVQQIYNKVIRSRFVQNKSGDSKVGRSNNLIS 401

  Fly   195 NDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLK 259
            .|:..:....:|.|.:..||::.....||:.:.:|.:|..|:...:|...:.:.||..::.|.|:
pombe   402 TDVDDIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLR 466

  Fly   260 TAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTP 324
            ....:|.|:.:|:|::..|::.|.:.||||....|...|..|:|....:...:..|......|..
pombe   467 ANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLMEICIQVLVESLPV 531

  Fly   325 VSIFLSLVGF-VLMGRFLTAEVAFLITAYYNVVRTNMT--AYFSVGVTQTAETLVSIKRVQKLLL 386
            .|:|.:.|.| .:||:.:|..:||...:.::.:||..:  ||.   :.|..:..|||.||...|.
pombe   532 FSMFATFVVFTTIMGQTITPSIAFTSISLFSFIRTQFSWIAYL---MRQIVQIFVSIGRVSDFLN 593

  Fly   387 SGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTN-SP-D 449
            .     .||....|..|:..||                         :........|.:| || |
pombe   594 D-----PDEVDPVNTIEDTSQE-------------------------IGFFNASLTWVSNPSPGD 628

  Fly   450 YTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGS--MSYASQEPWLFSGT 512
            :.|..:|:......|..::|.|||||||||.|:||||.:..|...:..|  :||.||.|||.:.|
pombe   629 FCLRDLNIVFPRNKLSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNAT 693

  Fly   513 VRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDA 577
            :|.||||..|....||..|::.|.|..|.:.....|.|.:|::|.:||||||.||:|||:||...
pombe   694 IRDNILFDYPYIEERYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPT 758

  Fly   578 SIYLLDDPLSAVDSSVARRLFEECLRGHL-RDKIVILVTHQLQ-FLQQADQIVIMEMGKVKAVGT 640
            ||.|:||..||:|...:..:::.|.:..| .::.||||||.:. |:..|..||.:
pombe   759 SIVLMDDVFSALDIHTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTV---------- 813

  Fly   641 YESLHKSGLDFGIVLDDPVNDNEA-----AEDRSRTS--SITDQRRSSVKSVLSHAESCPEDVG- 697
                 |:|..|      ||.|..:     ||..:..|  :..|.....:.:.:..||:..|..|
pombe   814 -----KNGSAF------PVTDKSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDDAEAADEKDGK 867

  Fly   698 ---EEQKINLQRQQLGRNGLGVYVDYF----RAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWV 755
               |||::         .|..|:.:.|    ..|.||. .:.|:.|||.:|..:.|.|.:::.|.
pombe   868 LVEEEQRV---------TGDVVFSEIFSYMKHFGSGFY-VAAVLLFFVTTQATSILIDLWVAFWT 922

  Fly   756 SRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGI 820
            :.:..      :.|..:..|    .::|..:.:...::...|:..:...|..||.:||:||...:
pombe   923 NSSVN------SPDVNNNKF----LFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLESV 977

  Fly   821 SRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALA 885
            ......:|:|.|.|.|:|||:||:..:|..|...:...|..||...|.|:.::...|:|:|||:.
pombe   978 FGTFASWFDKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAGGILSVSSAMPIFMIPAVI 1042

  Fly   886 FGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQD--- 947
            ..:..||....|.:..:.||||.:...||::|....|:.|:|.||||...:|.:..|....|
pombe  1043 VCLAGYYFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLDNLV 1107

  Fly   948 MHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVR 1012
            ...|.||   :.:|..|...|....|..|:..|...:....|...||.::.||:..:.:|...||
pombe  1108 RLQSTSY---NLNRWVAVRTDGISGLVGAIAGLIALLQKDLSPGVVGFSLNQAVIFSSSVLLFVR 1169

  Fly  1013 QSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLK 1077
            ....|:..|.|.||::||.:: |:.|....|.:.| .:||::|.|.|..:|:.|.  ....::||
pombe  1170 SCNSLQAEMNSYERVLEYSKL-PQEPAPTIAGQVP-ATWPKEGDIVFNHVSVSYS--AAGPTILK 1230

  Fly  1078 SLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN-DGSVRIDDKDTNDMGLHDLRSKISIIPQE 1141
            .::..|.|.|||.:|||||:|||:|...|.|.::. .|.:.|:.::|..:.|:.||.:||.|||:
pombe  1231 DVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQRISFIPQD 1295

  Fly  1142 PVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVAS-------VATGLETKITEGGSNFSVGQ 1199
            |:|||||||.|||||||..|:.|..||:......::.:       :...|:|.:...|||||.||
pombe  1296 PILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQKPIHITLDTHVASEGSNFSQGQ 1360

  Fly  1200 RQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLV 1264
            :|::.|||||:|.::|:::||.||:||...|..||.|:|..|.:.|:|.:||||.||:|.|:|:|
pombe  1361 KQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTIVDYDKVMV 1425

  Fly  1265 MDAGRVVEFGTP 1276
            :|.|.:||:|.|
pombe  1426 LDKGVLVEYGPP 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	393/1304 (30%)
		ABC_membrane	94..360	CDD:294371	67/269 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	82/205 (40%)
		ABC_membrane	736..980	CDD:294371	68/246 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	99/228 (43%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	390/1290 (30%)
		ABC_membrane	300..568	CDD:294371	67/269 (25%)
		ABCC_MRP_domain1	611..817	CDD:213217	83/220 (38%)
		ABC_membrane	901..1164	CDD:294371	74/275 (27%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	99/228 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810