DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abc3

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_595055.1	Gene:	abc3 / 2540937	PomBaseID:	SPBC359.05	Length:	1465	Species:	Schizosaccharomyces pombe

Alignment Length:	1379	Identity:	440/1379 - (31%)
Similarity:	697/1379 - (50%)	Gaps:	191/1379 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSALSF-WYTIPTFIK-GQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNASLL 79
            :||||.||| |  |.:||| |....|...|::....:.|:.:|.......|....:..:::..|.
pombe   177 ANIFSKLSFSW--ISSFIKFGYTNYLKESDVWLLPPDERSGNLIIGFEDWWIYHSKNKRRSLFLW 239

  Fly    80 RVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMK---LISSFSNPSPTSNGVAYAYAGGVILGSA 141
            ::||....:....:.:.....:|:..|||..:.|   .|||:::|:|.|....:..|..|::.:.
pombe   240 KLLFFNHWKLVALITITKLIQDVLAFVQPTLIQKTILFISSYTSPNPESPSRGFIIAILVLVANF 304

  Fly   142 LKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQF 206
            |:.:|:..|:..:..||::.:..:.:.||||.|.|:.:.....|.|.|||.::.|..::.....:
pombe   305 LQTLLLQQYNQLIMLLGMRWKTELLASIYRKSLLLSSSARQNRSIGDIINYMAVDTQKISDLPIY 369

  Fly   207 THYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLG---KKISGLRLKTAIRSDKRM 268
            ...:...|.|..:....:|..:|.:|..|:...::..|..:.:.   ||...:.:|   ..|.|.
pombe   370 LFIIVSGPFQIALALSNLYHLMGYSAFTGVAASVILFPCNIIVANVYKKFQSILMK---NKDSRS 431

  Fly   269 RIMTEIIAGIQVIKMYAWELPFEKMVAHARH-KEINSIRHVAYAKCL---IWSFNRFLTPVSIFL 329
            ::|||||..|:.||:||||.||.:.:.|.|: ||::.::.:.:...:   .|.|...:.....|.
pombe   432 KLMTEIINNIRSIKLYAWETPFLQKLLHIRNTKELSMLKKIGFITAIGDFAWIFTTIIVTTVAFG 496

  Fly   330 SLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKD 394
            :.:.|....:.|||::.|...:.:|:::..: |.....::...|..||:.|:.:.|::.|:   |
pombe   497 AFIIFHGKTQALTADIVFPAVSLFNLLQFPL-AMLPTVISSLLEASVSVSRIYEFLIAQEL---D 557

  Fly   395 ENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTN------SPDYTLS 453
            .|.|......::                    ||  |.|:.|......|:..      :|  ||.
pombe   558 YNGVQRFPATEI--------------------PH--EICLEIKSGTFSWSKKTLKQQVTP--TLR 598

  Fly   454 GVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNIL 518
            .:|.....|.|..|.|..|:|||||::|.:|.:...||.:...||::||:|:||:|..|:|:|||
pombe   599 QINFVAKNGELTCIFGKVGAGKSSLLEACMGNMYKNSGSVFQCGSLAYAAQQPWIFDATIRENIL 663

  Fly   519 FGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLD 583
            ||...|...|:..:..|.|:||||:....|:|.:|.:|||||||||:||||||::|..|.|||||
pombe   664 FGSEFDPELYEKTIHACCLKRDFEIFTEGDQTEVGQKGASLSGGQKSRISLARAIYSQADIYLLD 728

  Fly   584 DPLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYE---- 642
            |.||:||..|:|.|.:...  .|.||...|:|.|:.|..|::||.|.|:..||:...|.||
pombe   729 DVLSSVDQHVSRDLIKNLFGPEGFLRTHCVVLTTNSLNVLKEADSIYILSNGKIVEKGNYEHLFV 793

  Fly   643 --------------------------------------SLHKSGLDFGIVLDDPVNDNEAAEDRS 669
                                                  |:|..||:          ...::|.:.
pombe   794 STNSELKQQLSEFNDEKDTQPLPEHTTSYPSTQISLAPSIHVEGLE----------TYSSSERKD 848

  Fly   670 RTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNG---LGVYVDYFRAGGGFLSFS 731
            .::....::|:.::      :...||  ::.|...|..:|.:.|   ..||..||::
pombe   849 SSNKYKSRKRNPIR------QKVTED--DKGKCVAQTDELVQRGKVKWHVYWMYFKS-------- 897

  Fly   732 VVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHN-----YTTDAKDADFEMH-AAYIYMLITVLS 790
                   ||.||..|..:|:...:..|   ||.|     ::.:...:..|:: :.|.|:.|
pombe   898 -------CSIGLILLYFFFIISGIMMN---VATNVWLKHWSEENGKSSSELNPSPYFYLGI---- 948

  Fly   791 IMVTIKRSFLFFNL-----------------AMRASIQLHNSMFRGISRASMYFFNKNPAGSILN 838
                    :|||..                 .:|:...||:||.:.|.||.|.||....:|.|||
pombe   949 --------YLFFGFLSCAFISSSSLTMTVLCGIRSGRYLHDSMLKTILRAPMGFFETTSSGRILN 1005

  Fly   839 RFSKDMGQVDEMLPTIIM----TVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLK 899
            |||.|:.:|||::....|    ..||...:.|    ||....||.|:..:....:..|.|::|::
pombe  1006 RFSNDVYKVDEVVSLTFMFFFRNSIQVLFILG----VICYSAPLSLLLIVPLFFLYLYNRAYYVR 1066

  Fly   900 TSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFA 964
            ||.::|||:..||||:|:|...||:|||||||:|.......|.|...|.:....:||.|:||..|
pombe  1067 TSRELKRLDNVTRSPLYAHVQESLSGLSTIRAYGMQETFVEENDLRIDTNHRVWFMFFSSSRWQA 1131

  Fly   965 YWMD------IFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMIS 1023
            ..::      |||..|..:  ||.....|:... ||.:::.|:.:|..:.:.|:||.:.||..:|
pombe  1132 IRVECIGDLIIFCTAFYGI--LSAIKGSPNPGL-VGFSLSYAIQITQGLSFIVQQSVDAENNTVS 1193

  Fly  1024 VERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEK 1088
            |||::||..::.|.| |...:.:|...||..|.:.|...|.:|...|  ...|.:::..|.|:||
pombe  1194 VERILEYINVKSEAP-EIIPENRPPCEWPTDGAVSFNHYSAKYREDL--SFALNNINIEISPREK 1255

  Fly  1089 VGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHN 1152
            :|||||||||||:|..|||| :...:|.:.||::|....||:||||::||||||..:|.|.:|.|
pombe  1256 IGIVGRTGAGKSTLAMALFRIIEPTEGKIEIDNEDITKFGLYDLRSRLSIIPQESQIFEGNIREN 1320

  Fly  1153 LDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILV 1217
            |||....:|.::|..||...||:.::.:..||.:::.|||:|||.|||||:||||.:|...|||:
pombe  1321 LDPNHRLTDKKIWEVLEIASLKNCISQLEDGLYSRVAEGGANFSSGQRQLICLARVLLTSTRILL 1385

  Fly  1218 MDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTA 1282
            :|||||:|..:|||::|.|||.:|::.|:||||||::|:|||||:||:|.|:||||....:||..
pombe  1386 LDEATASVHAETDAIVQQTIRKRFKDRTILTVAHRINTVMDSDRILVLDHGKVVEFDATKKLLEN 1450

  Fly  1283 DDTNAFQDLVKQTG 1296
            .| :.|..|.|::|
pombe  1451 KD-SMFYSLAKESG 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	434/1362 (32%)
		ABC_membrane	94..360	CDD:294371	69/275 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/207 (43%)
		ABC_membrane	736..980	CDD:294371	85/276 (31%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/221 (50%)
abc3	NP_595055.1	MRP_assoc_pro	101..1464	CDD:188098	440/1379 (32%)
		ABC_membrane	254..527	CDD:294371	69/275 (25%)
		ABCC_MRP_domain1	575..781	CDD:213217	88/207 (43%)
		ABC_membrane	907..1177	CDD:279056	87/291 (30%)
		ABCC_MRP_domain2	1224..1443	CDD:213211	111/220 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	170	1.000	Domainoid score	I894
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720