DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31792 and Abcc2

DIOPT Version :9

Sequence 1:NP_001260548.1 Gene:CG31792 / 35163 FlyBaseID:FBgn0051792 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_036965.1 Gene:Abcc2 / 25303 RGDID:2366 Length:1541 Species:Rattus norvegicus


Alignment Length:1423 Identity:460/1423 - (32%)
Similarity:740/1423 - (52%) Gaps:212/1423 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DLPENPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELE- 70
            |..:.|...::..|:::| ||. .|.:||.|..|..:|::...:..:..|:.:|..::...:|: 
  Rat   188 DSTQTPSVTASFLSSITFSWYD-RTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQK 251

  Fly    71 ----------------------TNKKNAS-------------------------LLRVLFRVFGR 88
                                  .|||.:.                         |::.||:.|  
  Rat   252 ARQAFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTF-- 314

  Fly    89 YFVFLGLVLFCL--EVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYS 151
            :.|.|...:..|  ::::.:.|. |:||:..|..   :||  :|.:.|.:.      .|||    
  Rat   315 HVVILKSFILKLIHDLLVFLNPQ-LLKLLIGFVK---SSN--SYVWFGYIC------AILM---- 363

  Fly   152 FAVT------------H---LGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMD 201
            ||||            |   ||:.:|..|.|.||:|.|.|:.....:.:.|..:||:|.|..::.
  Rat   364 FAVTLIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLM 428

  Fly   202 TFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDK 266
            ....:...:|.:.:|..:..:.:::|:|.:.:.|:..::|.||:...|..||..::::.....||
  Rat   429 DATNYMQLVWSSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDK 493

  Fly   267 RMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFLSL 331
            |::||.||::||:::|.:|||..|::.|...|.||:.::......:.|: .|...:||  |.:|:
  Rat   494 RLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLL-IFILQITP--ILVSV 555

  Fly   332 VGF---VLM--GRFLTAEVAFLITAYYNVVR--TNMTAYFSVGVTQTAETLVSIKRVQKLLLSGE 389
            |.|   ||:  ...|.||.||.....:|::|  .:|....:..:.|.:   ||:.|:::.|    
  Rat   556 VTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQAS---VSVDRLERYL---- 613

  Fly   390 VVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDY--TL 452
                      .|.:.|....|.               ..|.:..|..||....|   .||.  |:
  Rat   614 ----------GGDDLDTSAIRR---------------VSNFDKAVKFSEASFTW---DPDLEATI 650

  Fly   453 SGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNI 517
            ..|||.:..|.|||:||..|||||||:.|:|||:....|.|.:.||.:|..|:.|:.:||::.||
  Rat   651 QDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNI 715

  Fly   518 LFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLL 582
            |||...:.::|..|::.|||..|.|:||..|...:|::|.:||||||.|:||||:.|:||.||:|
  Rat   716 LFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYIL 780

  Fly   583 DDPLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY-ESL 644
            ||||||||:.|.:.:|.:.:  .|.|..|..|.|||.:.||.|.|:||::..|.:...|:| :.|
  Rat   781 DDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLL 845

  Fly   645 HKSGL----------DFGIVLDDPVNDNEAAED------------------------------RS 669
            .|.|:          ..|...:..||::..|||                              .|
  Rat   846 DKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLS 910

  Fly   670 RTSSITDQRRSSVK--------SVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGG 726
            |:|..:.:|..|:|        :||...|   ::|..::.|..:..:.|:....:|:.|.:|.|.
  Rat   911 RSSRSSSRRGKSLKNSLKIKNVNVLKEKE---KEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGW 972

  Fly   727 FLSFSVVMTFFVCSQGLASLG-DYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAY-----IYML 785
            :....:::  |.....:|.:| :.:||.|.|.::.:...|.::..:|....:..|.     |.:|
  Rat   973 WSILFIIL--FYGLNNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLL 1035

  Fly   786 ITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEM 850
            |:.|..:...:          .||..||..:...|.||.|.||:..|.|.|:||||.|:..||::
  Rat  1036 ISTLWSIYACR----------NASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDL 1090

  Fly   851 LPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPV 915
            ||..:.:.:..|....|.:::|.:..|:|.|..:...|:...::.||:.||..::||::.|:||:
  Rat  1091 LPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPI 1155

  Fly   916 YSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITL 980
            ||||:.::.||..||||.......|..:...|::....:.:|:::|..|..:::...|.:....|
  Rat  1156 YSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSAL 1220

  Fly   981 SFFIFPPSSAAD-VGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATAD 1044
            ...|:..:...| ||..::.|:.:|.|:.|.||.::|.|..:::|||:.||..:|.|.|.  ..|
  Rat  1221 LLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPW--VTD 1283

  Fly  1045 KKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR- 1108
            |:|...||..|:|:|....:||.|.|  :.|||.::..||..||||:|||||||||||.|.||| 
  Rat  1284 KRPPADWPRHGEIQFNNYQVRYRPEL--DLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRI 1346

  Fly  1109 LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVEL 1173
            |....|.:.||..|...:||||||.:::||||:|:||||::|.|||||::|||:.:|.|||...|
  Rat  1347 LESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHL 1411

  Fly  1174 KDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIR 1238
            :..|:.:..||.:::||||.|.|:|||||:||.||:||.::|||:|||||.||.:||:|||.|||
  Rat  1412 RSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIR 1476

  Fly  1239 NKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTG 1296
            .:|.:|||:|:|||||||||||:::|:|.|::||:|:|.|||:  :..:|..:.|:.|
  Rat  1477 KEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLS--NRGSFYLMAKEAG 1532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31792NP_001260548.1 CFTR_protein 12..1281 CDD:273530 455/1402 (32%)
ABC_membrane 94..360 CDD:294371 79/289 (27%)
ABCC_MRP_domain1 434..634 CDD:213217 93/203 (46%)
ABC_membrane 736..980 CDD:294371 68/249 (27%)
ABCC_MRP_domain2 1055..1276 CDD:213211 125/221 (57%)
Abcc2NP_036965.1 MRP_assoc_pro 7..1533 CDD:188098 460/1423 (32%)
ABC_membrane 322..589 CDD:279056 79/285 (28%)
ABCC_MRP_domain1 633..834 CDD:213217 93/203 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 862..881 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 901..923 4/21 (19%)
ABC_membrane 979..1245 CDD:279056 74/277 (27%)
ABCC_MRP_domain2 1294..1514 CDD:213211 125/221 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166345101
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.660

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