DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc1

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_071617.2	Gene:	Abcc1 / 24565	RGDID:	3112	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	1386	Identity:	457/1386 - (32%)
Similarity:	727/1386 - (52%)	Gaps:	166/1386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW------------ 65
            |...::..|.::||:.....::|.:..|.:.||:...||..:|.:...|.::|
  Rat   209 PESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPV 273

  Fly    66 ---------------ANELETNK-------------KNASLLRVLFRVFGRYFVFLGLVLFCLEV 102
                           :::|:.|:             ::.||.:||::.||.||:...|.....::
  Rat   274 RIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDL 338

  Fly   103 ILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSS 167
            ::...|. :::||.:|.|.....:...|.|...:.:.:.|:.:.::.|.......|::|:..|..
  Rat   339 MMFAGPE-ILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVG 402

  Fly   168 MIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAA 232
            .:|||.|.:|.:.....:.|.|:||:|.|..|......:.:.:|.||||..:..|.::..:|.:.
  Rat   403 AVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSV 467

  Fly   233 VFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHA 297
            :.|:..::|.:|....:..|....::......|.|:::|.||:.||:|:|:|||||.|:..|.:.
  Rat   468 LAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNI 532

  Fly   298 RHKEINSIRHVAYAKCL---IWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTN 359
            |.:|:..::..||...:   .|....||..:|.|...| .|.....|.|:.||:..|.:|::|..
  Rat   533 RQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFV-TVDEKNILDAKKAFVSLALFNILRFP 596

  Fly   360 MTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDE----NVVSNGAEEDLQEAREKLLVTPTPM 420
            :.....| ::...:..||:||: ::.||.|.:..|.    ::...|.
  Rat   597 LNILPMV-ISSIVQASVSLKRL-RIFLSHEELEPDSIERWSIKDGGG------------------ 641

  Fly   421 RAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGE 485
                   .||   :::......|..:.|. ||:|:...:..|||||:||..|.|||||:.|:|.|
  Rat   642 -------MNS---ITVKNATFTWARDEPP-TLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAE 695

  Fly   486 LRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKT 550
            :....|.:.:.||::|..|:.|:.:.::|:|||||:|:....|..|:..|||..|.|:||..|.|
  Rat   696 MDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLT 760

  Fly   551 ILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVIL 613
            .:|::|.:||||||.|:||||:||.::.||||||||||||:.|.:.:||:.:  .|.|::|..||
  Rat   761 EIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRIL 825

  Fly   614 VTHQLQFLQQADQIVIMEMGKVKAVGTYESL--------------------------HKSG---- 648
            |||.:.:|.|.|.|::|..||:..:|:|:.|                          .|:|
  Rat   826 VTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEFVRTYANTEQDLASEDDSKNGVSGL 890

  Fly   649 ------LDFGIVLDDPVND--NEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEE--QKIN 703
                  ::.||::.|.|..  .....:.|..|.:|:|:.||.      ||.....|.||  :.:.
  Rat   891 GKESKPVENGILVTDAVGKPLQRHLSNSSSHSVVTNQQHSST------AELQKSGVKEETWKLME 949

  Fly   704 LQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTT 768
            ..:.|.|:..|.||.:|.:|.|..:||..:. .|:|:...|...:|:||.|   .:...|.|.|.
  Rat   950 ADKAQTGQVKLSVYWNYMKAIGLCISFLSIF-LFLCNHVSALASNYWLSLW---TDDRPAVNGTQ 1010

  Fly   769 DAKDADFEMHAAY-IYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNP 832
            :.::....::.|. |...:.|....:.:....:|      ||.:||..:.:.:.|:.|.||.:.|
  Rat  1011 ENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIF------ASRRLHLDLLQNVLRSPMSFFERTP 1069

  Fly   833 AGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPL--FLIPALAFGIVIYYLRS 895
            :|:::|||||::..||.|:|.:|...:.......|.:|:|.:..|:  .:||.|  |:|.::::.
  Rat  1070 SGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPL--GLVYFFVQR 1132

  Fly   896 FYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTS 960
            ||:.:|..:||||:.:||||||||..:|.|:|.||||........:.|...|.:..|.|..|..:
  Rat  1133 FYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVAN 1197

  Fly   961 RAFAYWMD-------IFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELE 1018
            |..|..::       :|..||..:...|.      ||..|||:::.::.:|..:.|.||.|:|:|
  Rat  1198 RWLAVRLECVGNCIVLFAALFAVISRHSL------SAGLVGLSVSYSLQITAYLNWLVRMSSEME 1256

  Fly  1019 NTMISVERMIEYEEIEPEG--PLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSF 1081
            ..:::|||:.||.|.|.|.  .::.||   |..:||..|::||.:..|||...|  :.|||.::.
  Rat  1257 TNIVAVERLKEYSETEKEASWQIQETA---PPSTWPHSGRVEFRDYCLRYREDL--DLVLKHINV 1316

  Fly  1082 VIKPKEKVGIVGRTGAGKSSLINALFRLSYN-DGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLF 1145
            .|:..||||||||||||||||...|||::.: :|.:.||..:...:|||:||.||:||||:||||
  Rat  1317 TIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLF 1381

  Fly  1146 SGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAIL 1210
            ||::|.|||||.:|||:.:|.|||...||..|:::...|..:..|||.|.|||||||||||||:|
  Rat  1382 SGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALL 1446

  Fly  1211 RDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGT 1275
            |..:|||:|||||.||.:||.|||:|||.:|.:.||||:||||:||||..||:|:|.|.:.|.|.
  Rat  1447 RKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGA 1511

  Fly  1276 PYELLTADDTNAFQDLVKQTG 1296
            |.|||  .....|..:.|..|
  Rat  1512 PSELL--QQRGVFYSMAKDAG 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	453/1369 (33%)
		ABC_membrane	94..360	CDD:294371	70/268 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/201 (44%)
		ABC_membrane	736..980	CDD:294371	75/253 (30%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	124/221 (56%)
Abcc1	NP_071617.2	MRP_assoc_pro	7..1531	CDD:188098	457/1386 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660