DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc12

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_766500.3	Gene:	Abcc12 / 244562	MGIID:	2441679	Length:	1366	Species:	Mus musculus

Alignment Length:	1367	Identity:	445/1367 - (32%)
Similarity:	730/1367 - (53%)	Gaps:	130/1367 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCS-SWANELE-T 71
            |..||.:.:.:.|..:|.:..|..|:..|.|| ..|....|..:.:..:..|... .|..|:: .
Mouse    41 LAPNPVDDAGLLSFATFSWLTPVMIRSYKHTL-TVDTLPPLSPYDSSDINAKRFQILWEEEIKRV 104

  Fly    72 NKKNASLLRVLFRVFGRYFVFLGLV--LFCLEVILTVQPMFLM-KLISSFSNPSPTSNGVAYAYA 133
            ..:.|||.||::: |.|..|.:.:|  :.|: |:..:.|..|: :::...::.|....|:
Mouse   105 GPEKASLGRVVWK-FQRTRVLMDVVANILCI-VMAALGPTVLIHQILQHITSISSGHIGI----- 162

  Fly   134 GGVILGSAL-----KVILMNPYSFAVTH-LGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINL 192
             |:.|..||     ..:|....::|:.: ..::::|.:|::|:...|.. || |..||.|.::|:
Mouse   163 -GICLCLALFTTEFTKVLFWALAWAINYRTAIRLKVALSTLIFENLLSF-KT-LTHISAGEVLNI 224

  Fly   193 ISNDLGRMDTFIQFTHYLWLAPLQA----LMVTYLMYQ--EIGIAAVFGMTFILLFIPLQMYLGK 251
            :|:     |::..|...|: .||.|    |||...:|.  .:|..|:.|::..|:|||:||::.|
Mouse   225 LSS-----DSYSLFEAALF-CPLPATIPILMVVCAVYAFFILGSTALVGISVYLIFIPIQMFMAK 283

  Fly   252 KISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIW 316
            ..|..|......:|||::.|.|.:..|::|||||||..|...:...|.:|...:....|    :.
Mouse   284 LNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREKKLLEKAGY----VQ 344

  Fly   317 SFNRFLTPVSIFLSLVG----FVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVS 377
            |.|..|.|:...:::|.    .:.:.|.|||.|||.:.|.:||::.:: |.....|...||..||
Mouse   345 SGNSALAPIVSTIAIVSTFTCHIFLKRKLTAPVAFSVIAMFNVMKFSI-AILPFSVKAVAEASVS 408

  Fly   378 IKRVQKLLLS---GEVVAKDEN-----VVSNGA---EEDLQEARE--KLLVTPTPMRAPEKPPHN 429
            ::|::|:|::   ...:.:.|:     :::|..   |:::....:  |..:....:...::|...
Mouse   409 LRRMKKILIAKSPPSYITQPEDPDTILLLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPELY 473

  Fly   430 SEDCVSISELKA-KWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEI 493
            ||...|...:.: :|.:.||...|..::..|..|.::.|.|:.||||||||.|:||:::::.|.:
Mouse   474 SEQSRSDQGVASPEWQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVV 538

  Fly   494 EVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGAS 558
            .|.|.::|.||:.|:|.|.||:|||||:..:.:||...|..|.|::|...||..|.|.:|:||.:
Mouse   539 AVNGPLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVN 603

  Fly   559 LSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQ 623
            |||||:.||||||:||.:..:|||||||||||:.|.:.:||||::..|:.|.|:|||||||||:.
Mouse   604 LSGGQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVVLVTHQLQFLES 668

  Fly   624 ADQIVIMEMGKVKAVGTYESLHKS------------GLDF-------GIVLDDPVNDNEAAEDRS 669
            .|:::::|.|::...||::.|.:.            ||.|       .:.:.:.:.::.|..|..
Mouse   669 CDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAMVETLKESPAQRDED 733

  Fly   670 RTSSITDQRRSSVKSVLSHAESCPEDVGEE--------------QKINLQRQQLGRNGLGVYVDY 720
            ...:..|::                |.|:|              |.|..:..|.|......|..|
Mouse   734 AVLASGDEK----------------DEGKEPETEEFVDTNAPAHQLIQTESPQEGIVTWKTYHTY 782

  Fly   721 FRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVA---HNYTTDAKDADFEMHAAYI 782
            .:|.||:|...:|:..|....|.::...::|..|:.|..::|.   :|.|....|...:....::
Mouse   783 IKASGGYLVSFLVLCLFFLMMGSSAFSTWWLGIWLDRGSQVVCASQNNKTACNVDQTLQDTKHHM 847

  Fly   783 YMLITVLS----IMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKD 843
            |.|:.:.|    :|..|.:.|.|.|..:.||..|||.:|..|.|:.|.||:..|.|.::||||||
Mouse   848 YQLVYIASMVSVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRFSKD 912

  Fly   844 MGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLE 908
            |.::|..||......:|.|.:....::::|.|.|:.|:......::...|...:.:...::|::|
Mouse   913 MDELDVRLPFHAENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELKQVE 977

  Fly   909 ASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIF--C 971
            ..:|||.:||..:|:.||..|.|:.......::|....|.:||....|....|.||..|||.  .
Mouse   978 NISRSPWFSHITSSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDILMNI 1042

  Fly   972 VLFIA--MITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEY-EEI 1033
            |.|:.  ::|||   |...||:..||:::..:.|:|.:|..||...|.:....|.|.:.|| ...
Mouse  1043 VTFVVALLVTLS---FSSISASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLREYILTC 1104

  Fly  1034 EPE--GPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTG 1096
            .||  .|.:.....|   .||.:|:|.|.:..:||..  .:..||..|:..|:..:.||||||||
Mouse  1105 VPEHTHPFKVGTCPK---DWPSRGEITFKDYRMRYRD--NTPLVLDGLNLNIQSGQTVGIVGRTG 1164

  Fly  1097 AGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYS 1160
            :|||||..||||| ....|::.||:.|...:||.|||:|:::|||:||||.||||:||||...::
Mouse  1165 SGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRYNLDPLGSHT 1229

  Fly  1161 DDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANV 1225
            |:.||..||...::|.:..:...|:.::||.|.|||||:|||:|:|||:||:::|:::|||||::
Mouse  1230 DEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEATASM 1294

  Fly  1226 DPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQD 1290
            |.:||.|:|:||:..|:.|||||:||||:|:::.|.||||:.|:|:||..| |:|.....:||..
Mouse  1295 DSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKP-EVLAEKPDSAFAM 1358

  Fly  1291 LV 1292
            |:
Mouse  1359 LL 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	440/1351 (33%)
		ABC_membrane	94..360	CDD:294371	79/284 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	92/200 (46%)
		ABC_membrane	736..980	CDD:294371	72/254 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	109/221 (49%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	444/1365 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..749		6/38 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660