DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Cftr

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_006236159.1	Gene:	Cftr / 24255	RGDID:	2332	Length:	1530	Species:	Rattus norvegicus

Alignment Length:	1490	Identity:	421/1490 - (28%)
Similarity:	718/1490 - (48%)	Gaps:	215/1490 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNK 73
            :.::|.|:::..|.|.|.:|.|...||.:..|...|:|:|.....|:.|..||...|..| :.:|
  Rat    55 MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSSDSADHLSEKLEREWDRE-QASK 118

  Fly    74 KNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVIL 138
            |...|:..|.|.|...|||.|::|:..||...|||:.|.::|:|:...:.....:|.....|:.|
  Rat   119 KKPQLIHALRRCFVWRFVFYGVLLYLGEVTKAVQPVLLGRIIASYDPDNTEERSIAIYLGIGLCL 183

  Fly   139 GSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTF 203
            ...::.:|::|..|.:.|:|:::|:.:.|:||:|.|:|:...|.:||.|.:|:|:||:|.:.|..
  Rat   184 LFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLISLLSNNLNKFDEG 248

  Fly   204 IQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRM 268
            :...|::|:||||.:::..|::..:..:|..|:..:::.:..|..|||.:...|.|.|.:.::|:
  Rat   249 LALAHFIWIAPLQVVLLMGLLWDLLQFSAFCGLGLLIVLVIFQAILGKMMVKYRDKRAAKINERL 313

  Fly   269 RIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWS---FNRFLTPVSIFLS 330
            .|.:|:|..|..:|.|.||...||::...|.:|:...|..||.:....|   |:.|..   :|||
  Rat   314 VITSEVIDNIYSVKAYCWESAMEKIIESLREEELKMTRRSAYMRFFTSSAFFFSGFFV---VFLS 375

  Fly   331 LVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDE 395
            ::.:.::...:..:: |...::..|:|.::|..|...|....::|..|:::|..|.:.|....:.
  Rat   376 VLPYTVINGIVLRKI-FTTISFCIVLRMSVTRQFPTAVQIWYDSLGMIRKIQDFLQTQEYKVLEY 439

  Fly   396 NVVSNGA---------EEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYT 451
            |::..|.         ||..||..||:     .:...::...|.|:.:|.|.|   ....:|  .
  Rat   440 NLMFTGLVMENVTAFWEEGFQELLEKV-----QLNNDDRKTSNGENHLSFSHL---CLVGNP--V 494

  Fly   452 LSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQN 516
            |..:||.:..|.::||.|.||:||:||:..|||||....|.|:.:|.:|::||..|:..||:::|
  Rat   495 LKNINLNIKKGEMLAITGSTGAGKTSLLMLILGELEASEGIIKHSGRVSFSSQISWIMPGTIKEN 559

  Fly   517 ILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYL 581
            |:||...|..||..||:.|.|:.|......:|.|:||:.|.:|||||:|||||||:||:||.:||
  Rat   560 IIFGVSYDEYRYKSVVKACQLQEDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLYL 624

  Fly   582 LDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHK 646
            ||.|...:|.....::||.|:...:..|..||||.:::.|::||:|:|:..|.....||:..|..
  Rat   625 LDSPFGYLDVLTEEQIFESCVCKLMASKTRILVTSKMEQLKKADKILILHEGSSYFYGTFSELQS 689

  Fly   647 SGLDFGIVL----------------------------DDPVNDNEAAEDRSRTSSITDQRRSSVK 683
            ...||...|                            |.....|:|.:...:|....::|::|:.
  Rat   690 LRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDASTTWNKAKQSFRQTGEFGEKRKNSIL 754

  Fly   684 SVLS----------------------------------HAESC---------------------- 692
            |..|                                  |.|:.
  Rat   755 SSFSSVKKISIVQKTPLSIEGESDDLQERRLSLVPDSEHGEAALPRSNMITAGPTFPGRRRQSVL 819

  Fly   693 ------PEDVGEE--------------QKINLQRQQLGRNGL----------------------- 714
                  |..|...              .:|:|:.:.:....|
  Rat   820 DLMTFTPSSVSSSLQRTRASIRKISLAPRISLKEEDIYSRRLSQDSTLNITEEINEEDLKECFFD 884

  Fly   715 -----------GVYVDYFRAGGGFLSFSV--VMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNY 766
                       ..|:.||....|..:..:  |:.|.|  :..|||  :.|  |:.:|..:...|.
  Rat   885 DMVKIPTVTTWNTYLRYFTLHRGLFAVLIWCVLVFLV--EVAASL--FVL--WLLKNNPVNGGNN 943

  Fly   767 TTDAKDADFEM--------HAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRA 823
            .|...:..:.:        :..|||:.:....:.:::.|.....:..:.||..||..|...|..|
  Rat   944 GTKIANTSYVVVITSSSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILHA 1008

  Fly   824 SMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP-LFL--IPALA 885
            .|..|||..||.||||||||:..:|:.||..|...||...:..|.|||::.:.| :||  :|.||
  Rat  1009 PMSTFNKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLLFIVVGAIIVVSALQPYIFLATVPGLA 1073

  Fly   886 FGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHS 950
               |...||:::|.||..:|:||:..|||:::|...||.||.|:|||...:..|..|....::|:
  Rat  1074 ---VFILLRAYFLHTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLHT 1135

  Fly   951 SASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSA 1015
            :..:|:::|.|.|...:|:..|||..::|....:.........|:.:|.||.:..|:||.|..|.
  Rat  1136 ANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTTGIILTLAMNIMSTLQWAVNSSI 1200

  Fly  1016 ELENTMISVERMIEYEEIEPEGPL--------------EATADKKPH----ESWPEQGKIEFVEL 1062
            :.::.|.||.|:.::.:|:.|..:              .|...|..|    ::||..|::...:|
  Rat  1201 DTDSLMRSVSRVFKFIDIQTEESICTKIMKELHSEDSPNALVIKNEHVKKCDTWPSGGEMVVKDL 1265

  Fly  1063 SLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMG 1127
            :::|..  ...::|:::||.|.|.::||::||||:|||:|::|..|:....|.::||....|.|.
  Rat  1266 TVKYVD--DGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGEIQIDGVSWNSMT 1328

  Fly  1128 LHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGG 1192
            |.:.|....:|.|:..:||||.|.||||..::.|:.:|...::|.||.|:......|...:.:||
  Rat  1329 LQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWRDEEIWKVADQVGLKSVIEQFPGQLNFTLVDGG 1393

  Fly  1193 SNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIM 1257
            ...|.|.:||:||||::|...:|:::||.:||:||.|..:|:..:|..|..|||:...||:..::
  Rat  1394 YVLSHGHKQLMCLARSVLSKAKIILLDEPSANLDPITYQVIRRVLRQAFAGCTVVLCEHRIEAML 1458

  Fly  1258 DSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKP 1317
            |..|.||::.|.|.::.:...||:  :.:.||..:..:.:      :|:........:||
  Rat  1459 DCQRFLVIEQGNVWQYESLQALLS--EKSVFQRALSSSEK------MKLFHGRHSSKQKP 1510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	415/1449 (29%)
		ABC_membrane	94..360	CDD:294371	76/268 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	83/199 (42%)
		ABC_membrane	736..980	CDD:294371	83/254 (33%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	78/220 (35%)
Cftr	XP_006236159.1	CFTR_protein	55..1518	CDD:273530	421/1490 (28%)
		ABC_membrane	139..357	CDD:294371	67/217 (31%)
		ABCC_CFTR1	444..724	CDD:213258	99/289 (34%)
		CFTR_R	693..898	CDD:291094	18/204 (9%)
		ABC_membrane	915..1196	CDD:279056	92/289 (32%)
		P-loop_NTPase	1258..1518	CDD:304359	85/263 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950