DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001334325.1	Gene:	Abcc10 / 224814	MGIID:	2386976	Length:	1526	Species:	Mus musculus

Alignment Length:	1374	Identity:	444/1374 - (32%)
Similarity:	689/1374 - (50%)	Gaps:	170/1374 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SALSFWYTIPTFIKGQKVTL-GAKDLYRALKEHRAESLGNKLCSSWANELETNKKNASLLRVLFR 84
            |..|:.:..|...:|.:..| ..:|..|..:......|.....:.|       |:.|.|.|.|:|
Mouse   223 SRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHW-------KEGAQLWRALYR 280

  Fly    85 VFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSF--SNPSPTSNGVAYAYAGGVILGSALKVILM 147
            .||..::.||| |..:..:|......|:.|:..|  ....|.|:|:.|..  |:..|:.:..:|.
Mouse   281 AFGCCYLALGL-LKMVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYVL--GLAGGTVISAVLQ 342

  Fly   148 NPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWL 212
            |.|.:.|..:.|:.||.|.|.:|||.|:|..:   ...||.::||:..|..|:..|....|..|.
Mouse   343 NQYGYEVRKVTLQARVAVLSTLYRKALKLGPS---RPPTGEVLNLLGTDSERLLNFAGSFHEAWG 404

  Fly   213 APLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAG 277
            .|||..:..||:||::|:|.:.|:...||.:|:...:..:|.....:.....|.|:::|||:::|
Mouse   405 LPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHKDARVKLMTELLSG 469

  Fly   278 IQVIKMYAWELPFEKMVAHARHKEINSIRHVAY--AKCL-IWSFNRFLTPVSIFLSLVGFVLMGR 339
            |:|||.:.||......|...|.||:..:|.:.|  |.|: :|:....:..::||::   :||||.
Mouse   470 IRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFIT---YVLMGH 531

  Fly   340 FLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEE 404
            .|||...|...|...::...:..:..| :....|:.||:.|:|:.|
Mouse   532 QLTATKVFTALALVRMLILPLNNFPWV-INGLLESKVSLDRIQRFL------------------- 576

  Fly   405 DLQEAREKLLVTPTPMRAPE-----KPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGAL 464
            ||            |..:||     .||......:.:.|....|............:|||..|.|
Mouse   577 DL------------PSYSPEAYYSPDPPAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGML 629

  Fly   465 VAIVGHTGSGKSSLIQAILGELRVESGEI---EVTGSMSYASQEPWLFSGTVRQNILFGQPMDRR 526
            |.|||..|.|||||:.||.|||....|.:   |::.....|:||||:...|:|.|||||:..|.:
Mouse   630 VGIVGKVGCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQ 694

  Fly   527 RYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDS 591
            .|..|:..|||..|..:||..|:|.:|::|.:|||||:|||:|||:||::.::|||||||:|||:
Mouse   695 LYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDA 759

  Fly   592 SVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLD 656
            .||..|...|:.|.|.....:|.||:.::|::||.:::||.|::...|....:        :.|.
Mouse   760 DVANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEI--------LPLV 816

  Fly   657 DPVNDNEAAEDRSRTS----SITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVY 717
            ..|....|.:::..||    |:.|..|::.:.:.....:|...|.||.|..      |...|.||
Mouse   817 QAVPTAWAEKEQVATSGQSPSVCDLERTTEEELEVEQSTCGCLVQEESKSE------GAVALHVY 875

  Fly   718 VDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVS-----RNEKMVAHNYTTDAKDADFE- 776
            ..|:||.|..|:.:::::..: .|...:..|::|:.|:|     ||.........:....|.|.
Mouse   876 RAYWRAMGSGLAAAILVSLLL-MQATRNGADWWLAHWLSQLKAGRNGSREDPASCSPGSTALFSP 939

  Fly   777 ------------------MHAA------------YIYMLITVLSIMVTIKRSFLFFNLAMRASIQ 811
                              :|.|            .:|..|..::.:.|:.|:.||...|::|:..
Mouse   940 RLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNSLCTLLRAVLFAAGALQAAAS 1004

  Fly   812 LHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVN 876
            ||:.:...:..|.:.|::..|:|.:|||||.|:..||:.||.::..::.:.:...|.:.|:....
Mouse  1005 LHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGL 1069

  Fly   877 P--LFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILE 939
            |  |.|:|.|:|  |.|.::.:|..:..:::||.:.|.||:|||.|.:|.||..:||.||....|
Mouse  1070 PWLLLLLPPLSF--VYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFE 1132

  Fly   940 AEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLF----------IAMITLSFFIFPPSSAADVG 994
            .|.....:::....:    .|.|...|:||...|.          ||::.....:..|..   ||
Mouse  1133 EENQRLLELNQRCQF----ASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGL---VG 1190

  Fly   995 LAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHE---SWPEQGK 1056
            |.::.|:.|||.:...|....:.|..|:||||:.||....|:.| .:...:.||:   ||..||.
Mouse  1191 LVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEP-HSQPLQSPHQQRISWLTQGS 1254

  Fly  1057 IEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDD 1120
            :||.::.|.|.|.|  .:.|..::|.::|.||:|||||||:|||||...||| |..|.|.|.:|:
Mouse  1255 VEFQDVVLVYRPGL--PNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDN 1317

  Fly  1121 KDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVV-------- 1177
            .||:.:.|.:|||::::|||||.|||||:|.||||...:.|..||.|||:..|.:|.
Mouse  1318 VDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQA 1382

  Fly  1178 ----------------ASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVD 1226
                            |.:..||:.::.|.|.|.|:|||||:|||||:|.|.:||.:|||||:||
Mouse  1383 CQRSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVD 1447

  Fly  1227 PQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDL 1291
            .:||.|:|.||..:|...||||:||||:||::||||||:.||||||..:| ..|.....:.||.|
Mouse  1448 QKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP-SALRNQPHSLFQQL 1511

  Fly  1292 VKQTGQATY 1300
            ::.:.|..:
Mouse  1512 LQSSQQGAH 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	439/1353 (32%)
		ABC_membrane	94..360	CDD:294371	82/270 (30%)
		ABCC_MRP_domain1	434..634	CDD:213217	86/202 (43%)
		ABC_membrane	736..980	CDD:294371	72/291 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	118/245 (48%)
Abcc10	NP_001334325.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841737
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650