DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc9

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_035641.1	Gene:	Abcc9 / 20928	MGIID:	1352630	Length:	1546	Species:	Mus musculus

Alignment Length:	1380	Identity:	429/1380 - (31%)
Similarity:	712/1380 - (51%)	Gaps:	161/1380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNA------ 76
            |:.|..::|:.....|...:..:..|.:.:.....||  :.|.:|...|.| |..||.|
Mouse   221 NLLSKATYWWMNTLIISAHRKPIDLKAIGKLPIAMRA--VTNYVCLKEAYE-EQKKKAADHPNRT 282

  Fly    77 -SLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNG-----------VA 129
             |:...::|.|||..:......:..:::....|:.:..::...:..:.|:..           :.
Mouse   283 PSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNEKTNTTREMFPETLSSKEFLE 347

  Fly   130 YAYAGGVILGSALKVILMNPY---SFAVT-HLGLKIRVGVSSMIYRKCLRLTKTDL--GEISTGH 188
            .|:...|:|..||  ||...:   |:.|| ..|:.:|..:.:|||.|.|||:.::|  ||::.|.
Mouse   348 NAHVLAVLLFLAL--ILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQ 410

  Fly   189 IINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKI 253
            |.||::.:..::..|:.....||..|:|.:|...|:|..:|.:|:.|...|:|..|:|.::..|:
Mouse   411 INNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKL 475

  Fly   254 SGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSF 318
            :..:..|...|.:|::...||:.||:::|:||||..|.|.|...|.||::|::..|
Mouse   476 AEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFA--------- 531

  Fly   319 NRFLTPVSIFLS--------LVGFV----LMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQT 371
              ..|.:|||::        |..||    ..|..|....||...:.::::.|.:....:| |...
Mouse   532 --LYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTV-VRFA 593

  Fly   372 AETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLL----------VTPTPM------ 420
            .:.::|::::.:.|||.|:            .||...|.|..|          |...|:
Mouse   594 VKAIISVQKLNEFLLSDEI------------GEDSWRAGEGTLPFESCKKHTGVQSKPINRKQPG 646

  Fly   421 --------RAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSS 477
                    :|....|..:|| ::|......::..|...|||.:::::..|.|..|||..|.||||
Mouse   647 RYHLDSYEQARRLRPAETED-IAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSS 710

  Fly   478 LIQAILGELRVESGEI------------EVTGSMS-----YASQEPWLFSGTVRQNILFGQPMDR 525
            |:.|||||::...|::            |.|.|.|     ||:|:|||.:.||.:||.||.|.:|
Mouse   711 LLLAILGEMQTLEGKVYWNNVNESEPSFEATRSRSRYSVAYAAQKPWLLNATVEENITFGSPFNR 775

  Fly   526 RRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVD 590
            :||..|...|:|:.|.:|||..|:|.:|:||.:|||||:.||.:||::|::.:|..||||.||:|
Mouse   776 QRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALD 840

  Fly   591 SSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGI 653
            ..::..|.:|.:...|:|  :.|:||||:||:|..||.|:.|:.|.|...||.:.:....::...
Mouse   841 IHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYE 905

  Fly   654 VLDDPVN--DNEAAEDRSRTSSITDQRRSSVKSVLS-HAESCPEDVGEEQKINLQRQQLGRNGLG 715
            .....:|  |.|..:| ......|.:|::..:::.| .|::..||..||:    :.::...:.:.
Mouse   906 HWKTLMNRQDQELEKD-MEADQTTLERKTLRRAMYSREAKAQMEDEDEEE----EEEEDEEDNMS 965

  Fly   716 VYVD------------YFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTT 768
            ..:.            |..:||.||.|.::.:..:....:.:: ||:|:.|.|  |..:.|....
Mouse   966 TVMRLRTKMPWKTCWWYLTSGGFFLLFLMIFSKLLKHSVIVAI-DYWLATWTS--EYSINHPGKA 1027

  Fly   769 DAKDADFEMHAAYI--YMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKN 831
            |        ...|:  :.::....|.:.:..|.....:.:.|:..||:::...|....:.||:..
Mouse  1028 D--------QTFYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTT 1084

  Fly   832 PAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSF 896
            |.|.||||||.|...:|:.:|..:.::.:..||....|.:|:...|:||:.....|:..|:::.:
Mouse  1085 PLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALAPLGVAFYFIQKY 1149

  Fly   897 YLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSR 961
            :...|.|::.|:.||:.|:..||:.:..||:|||||...:..:.......|.::.| |:|:|.:.
Mouse  1150 FRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA-YLFLSAAN 1213

  Fly   962 AFAYWMDI------FCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENT 1020
            .   |:::      .|::..|.|.   .|...|::..|||.:..|:.:|..:.|.||..|:||..
Mouse  1214 R---WLEVRTDYLGACIVLTASIA---SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQ 1272

  Fly  1021 MISVERMIEYEEIEPEGPLEATAD-KKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIK 1084
            |.:|:::..:..:|.|. .|.|.| .:..|.||::|:|:..:|.:|||..||  .|||.:...||
Mouse  1273 MGAVKKVNSFLTMESEN-YEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK--PVLKHVKAYIK 1334

  Fly  1085 PKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGT 1148
            |.:||||.||||:|||||..|.||: ...||.:.||..|.:.:.||.|||::|||.|:|:||||:
Mouse  1335 PGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGS 1399

  Fly  1149 VRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDN 1213
            :|.||||..:.:|||||.|||..:||::|.|:..||:..:||||.|||||||||.|||||.:|.:
Mouse  1400 IRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDATVTEGGENFSVGQRQLFCLARAFVRKS 1464

  Fly  1214 RILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYE 1278
            .||:||||||::|..|:.::|..:...|.:.||:|:|||:|||:.:|.|:||..|.::|:.||..
Mouse  1465 SILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPES 1529

  Fly  1279 LLTADDTNAFQDLVK 1293
            ||..:| ..|...|:
Mouse  1530 LLAQED-GVFASFVR 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	425/1366 (31%)
		ABC_membrane	94..360	CDD:294371	76/294 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/218 (40%)
		ABC_membrane	736..980	CDD:294371	61/251 (24%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	114/221 (52%)
Abcc9	NP_035641.1	MRP_assoc_pro	23..1543	CDD:188098	428/1378 (31%)
Abcc9	NP_035641.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841665
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.640