DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc8

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_036008753.1	Gene:	Abcc8 / 20927	MGIID:	1352629	Length:	1597	Species:	Mus musculus

Alignment Length:	1432	Identity:	430/1432 - (30%)
Similarity:	706/1432 - (49%)	Gaps:	216/1432 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFIKGQKVTLGAKDL-YRALKE----HRAESLGNKLCSSW----ANELETNK 73
            |:.|..::|: :..|||    |...|.: .||:.:    .||.:...:||:::    ..:.::.:
Mouse   223 NLLSKGTYWW-MNAFIK----TAHRKPIDLRAIGKLPIAMRALTNYQRLCAAFDAQARKDTQSQQ 282

  Fly    74 KNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFS------NPSPTSNGVAY-- 130
            ...::.|.|...|||..|.........:::....|:.:..::....      .|.....||.:
Mouse   283 GARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVS 347

  Fly   131 -------AYAGGVILGSAL---KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDL--GE 183
                   ||...|:|..||   :..|...|..|: ..|:.:|..:.:.||.|.:.|:.::|  ||
Mouse   348 SQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAI-ETGINLRGAIQTKIYNKIMHLSTSNLSMGE 411

  Fly   184 ISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMY 248
            ::.|.|.||::.|..::..|......||..|:|.::...|:|..:|::|:.|...|:|..|:|.:
Mouse   412 MTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYF 476

  Fly   249 LGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKC 313
            :..|:|..:..|...|::|::...|::.||:::|:||||..|...|...|.||:.|:|..|....
Mouse   477 VATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEMTRRKEMTSLRAFAVYTS 541

  Fly   314 LIWSFNRFLTPVSIFLSLVGFVLMGR--FLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLV 376
            :....|..:...::.::.||.|...:  ..:..|||...:.::::.|.:....|| |..|.:.||
Mouse   542 ISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSV-VRSTVKALV 605

  Fly   377 SIKRVQKLLLSGEV---------------VAKDENV---VSNGAEEDLQEAREKLLVTPTPMRAP 423
            |::::.:.|.|.|:               ..|.:.|   |.|......:|.|:  |:.|.....|
Mouse   606 SVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRD--LLGPLQRLTP 668

  Fly   424 EKPPHNSEDCVSISELKAKWTTNSPD--YTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGEL 486
            .........||.|......||   ||  .|||.:.:::..|.|..|||..|.|||||:.|.|||:
Mouse   669 SMDGDADNFCVQIIGGFFTWT---PDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEM 730

  Fly   487 RVESGEI---------------------------------EVTGSMSYASQEPWLFSGTVRQNIL 518
            :..||.:                                 ...|.::||||:|||.:.||.:||.
Mouse   731 QRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETAADSDARSRGPVAYASQKPWLLNATVEENIT 795

  Fly   519 FGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLD 583
            |..|.:::||.:|:..|:|:.|.::||..|:|.:|:||.:|||||:.|||:||::|:..::..||
Mouse   796 FESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLD 860

  Fly   584 DPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHK 646
            ||.||:|..::..|.:..:...|||  :.|:||||:||:|..||.|:.|:.|.::..||.:...:
Mouse   861 DPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQR 925

  Fly   647 SGLDF----------------------------------------GIVLDDPVNDNEAAEDRSRT 671
            |....                                        |::||:...:.||||
Mouse   926 SECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAE----- 985

  Fly   672 SSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFS--VVM 734
                .:...::.|||......|                           :||...:||.:  :::
Mouse   986 ----SEEDDNLSSVLHQRAKIP---------------------------WRACTKYLSSAGVLLL 1019

  Fly   735 TFFVCSQGLASLG----DYFLSPWVSRNEKMV----AHNYTTDAKDADFEMHAAYIYMLITVLSI 791
            :..|.||.|..:.    ||:|:.|.  :..:|    |.|.:...:.|..:...|.::.::..|.|
Mouse  1020 SLLVFSQLLKHMVLVAIDYWLAKWT--DSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGI 1082

  Fly   792 MVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIM 856
            .:.:..|.......::.:.:||.|:...|..|.|.||...|.||||||||.|...:|:.:|:.:.
Mouse  1083 ALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLE 1147

  Fly   857 TVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAA 921
            .:.:..||....:.||:.|.|:||:..|...:|.|:::.::...|.|:::|:.:|:.|:.||||.
Mouse  1148 CLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAE 1212

  Fly   922 SLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI---------------FC 971
            ::.||:|||||...:..:.:...|.|.::.||....:.:|    |:::               .|
Mouse  1213 TVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMPGPAAVLPQEYIGAC 1273

  Fly   972 VLFIAMIT-LSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVER---MIEYEE 1032
            |:.||..| :|..:....||..|||.:|.|:.::..:.|.||..|::|..:.:|:|   :::.|.
Mouse  1274 VVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEA 1338

  Fly  1033 IEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGA 1097
            ...||.|..:...|   :||:||||:...||:||:..||  .|||.::.:|.|.:|:||.||||:
Mouse  1339 ESYEGLLAPSLIPK---NWPDQGKIQIQNLSVRYDSSLK--PVLKHVNALIAPGQKIGICGRTGS 1398

  Fly  1098 GKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSD 1161
            ||||...|.||: ...:|.:.||..|...:.||.|||::|||.|:|||||||:|.||||..:.||
Mouse  1399 GKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSD 1463

  Fly  1162 DRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVD 1226
            ..||.|||..:||.||.::..||:..|||||.|||.|||||.|||||.:|...|.:||||||::|
Mouse  1464 STLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASID 1528

  Fly  1227 PQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDL 1291
            ..|:.::|..:...|.:.||:|:|||:|||:.:|.|:|:..|.::||..|.:||:..| :.|...
Mouse  1529 MATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKD-SVFASF 1592

  Fly  1292 VK 1293
            |:
Mouse  1593 VR 1594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	426/1418 (30%)
		ABC_membrane	94..360	CDD:294371	70/287 (24%)
		ABCC_MRP_domain1	434..634	CDD:213217	87/236 (37%)
		ABC_membrane	736..980	CDD:294371	74/267 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/221 (50%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	428/1429 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841685
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650