DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and mrp-8

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_499598.2	Gene:	mrp-8 / 190710	WormBaseID:	WBGene00003414	Length:	1461	Species:	Caenorhabditis elegans

Alignment Length:	1373	Identity:	439/1373 - (31%)
Similarity:	704/1373 - (51%)	Gaps:	146/1373 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELET 71
            :.:.:.|.|:|:..|.:.|.:..|....|.|..|..:.|:...:...:|.|..:    |..|.:.
Worm   171 QKIEQTPEEKSSFLSKIFFCWLNPLIRAGAKQPLTNESLHNLNENATSEWLYTR----WRAEFDK 231

  Fly    72 NKK-----NASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFS-NPSPTSNGVAY 130
            .|.     ..|::....|:.....:.|.|.....:::..:.|:.|.:||...| :..|.|.|:|.
Worm   232 EKAGRKSGETSIVWPFIRIQRATIITLTLARLTADIVHYLNPILLKQLIDYVSLHDQPLSFGIAI 296

  Fly   131 AYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISN 195
            |..  :...|..:.:|.|.....:....:..:..:|:.|..|.|||:.:.....:.|.|:|..:.
Worm   297 ACI--MFSCSTTRSLLQNYQIAGMCRQAVYYQTVLSNAILHKILRLSPSARSNRTAGEILNHAAV 359

  Fly   196 DLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKT 260
            |:..:...:.:...:|..|.|..:...::...:|.||:.|:..::|||||.:...:.|...:.|.
Worm   360 DIEIIVHSVPYLQNMWSVPFQVTLAMTMLAITLGWAAMAGVCIMILFIPLNLCTSRFIKLSQQKQ 424

  Fly   261 AIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPV 325
            ....|:|.::..|::.||:|:|:||||..||..:...|.||:..:|:|    |::..........
Worm   425 MKIKDERTKLSNEMLNGIKVVKLYAWEESFEDQINRLRAKEVKMLRNV----CILSRIVDVANAA 485

  Fly   326 SIFLSLVG----FVLMG---RFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQK 383
            |.||..:|    :||..   ..||..|||:....:|.:|..|....:: :....:..||.||:::
Worm   486 SPFLVAIGSFTCYVLWSPDENGLTPSVAFVALTIFNQLRQPMRMVANL-INTLVQARVSNKRLRQ 549

  Fly   384 LLLSGEVVAKDENVVSNGAEEDLQEAREKLLV---TPTPMRAPEKPPHNSEDCVSISELKAKWTT 445
            .|...|:..|.|..:.|.            :|   .....:.|:.||
Worm   550 FLNDEEMERKTEVALGNA------------IVFKNASLNWKGPQNPP------------------ 584

  Fly   446 NSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFS 510
                 .|..::..:..|.|:||||..|.|||||:.|:|.|:.:..|.::|.||::|..|..|:|:
Worm   585 -----VLKDLSATIKPGQLIAIVGSVGGGKSSLLSAVLDEMVLLDGRVKVGGSIAYVPQHSWIFN 644

  Fly   511 GTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYR 575
            .|:::|||||..:....||.||..|.|:.||......:.|::|:.|.:|||||||||||||:||:
Worm   645 KTIKENILFGNELSNYFYDQVVGSCQLKTDFRHFQQGENTMVGENGITLSGGQKARISLARAVYQ 709

  Fly   576 DASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAV 638
            |..||||||||||||:.|.|.||::.:  .|.||.|..:||||.||:.:..|.|.::|.|::...
Worm   710 DKDIYLLDDPLSAVDAHVGRALFDKVIGPDGLLRSKTRVLVTHNLQYTKYVDTIYVIEDGQIVQH 774

  Fly   639 GTYESLHKSGLDFGIVLDDPVN-DNEAAEDRSRTS--SITD-------------QRRSSVKSVLS 687
            |::|.:......||.:..:..| |.:.|::.:.:|  |:|.             ::.|.:....|
Worm   775 GSFEDIAYVDGPFGRLWSECENSDEDVADEEAESSEASVTPPVPVLENGDNGAIEKSSQIDRTNS 839

  Fly   688 H-AESCPEDVGEEQKI--NLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDY 749
            | :|...:...:.||:  |::..||||....||..|.:..|.|.| |..:.||:....:..:...
Worm   840 HFSEKSRKSEEKPQKVEKNVENVQLGRVKKSVYQLYIKTMGIFNS-SAFLIFFIAHFTVMIMRSL 903

  Fly   750 FLSPWVSRNEKM-------VAHNYTTDAKDADFEMHAAYIY--------MLITVLSIMV-TIKRS 798
            :||.|.:.|..:       |.:..:|.:.|....:....|.        ||:..|:..| ||.
Worm   904 WLSDWSNENAAIKKATLSSVDYLNSTSSVDGPVSVETRLIVYAGFGGLEMLLLALAFTVLTIG-- 966

  Fly   799 FLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIM---TVIQ 860
                  ::|||..||:.:...:..|.:.||:..|.|.|:||.|:|:..:|::...|.|   |::.
Worm   967 ------SLRASYGLHSPLIHALLVAPISFFDTTPTGRIINRLSRDLDVIDKLQDNIRMCTQTLLN 1025

  Fly   861 DFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNG 925
            ..::    :::|:|..|:||:.|....::.|::..:|:.||..:||||::.|||:.|..|.|::|
Worm  1026 ACMI----LVLISISTPIFLVCAAPLILIYYFVMIYYIPTSRQLKRLESANRSPILSTIAESIHG 1086

  Fly   926 LSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIF---CVLFIAM-ITLS--FFI 984
            .|:||||..............|..:...|:...::|..|..:::.   ||||.:: .|||  :|.
Worm  1087 ASSIRAFDKTERTTTALSTNVDKFAQCRYLSHMSNRWLATRLELLGNTCVLFASLSATLSTKYFG 1151

  Fly   985 FPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHE 1049
            ..|..|   ||:::.|:.:|..:...||..:|:|:.::||||:.||:::|||.|.......:..|
Worm  1152 LTPGMA---GLSVSYALTITEVLNICVRSVSEIESNIVSVERVNEYQKLEPEAPWRIEKSLENEE 1213

  Fly  1050 SWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYND- 1113
            .||.:||||....|:||...|  ..|||::...|:..|::|::||||:|||||..||:|:...:
Worm  1214 KWPVKGKIELDGFSMRYRKNL--PLVLKNIDLKIEGGERIGVIGRTGSGKSSLTMALYRMIEGES 1276

  Fly  1114 GSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVA 1178
            |:::|||.:.:.:|||.||||:.|||||||:||||:|.|||||::||||::|..||..:||....
Worm  1277 GTIKIDDVEIDTIGLHQLRSKLIIIPQEPVVFSGTLRFNLDPFNQYSDDQIWNCLEICQLKQFAQ 1341

  Fly  1179 SVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRE 1243
            .....|:..|.|||.|.|||:|||:||.||:||..||:::|||||:||..||.::|..||..|.:
Worm  1342 EDDKTLDRYIAEGGKNMSVGERQLLCLCRALLRGARIVILDEATASVDTVTDGIVQRAIRQHFPQ 1406

  Fly  1244 CTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQ 1308
            .|.:::||||.||:||||::|:|||||.||.||..||...|             :.|..||.
Worm  1407 STTISIAHRLDTIVDSDRIVVLDAGRVAEFDTPSNLLLNPD-------------SLYSQLLN--- 1455

  Fly  1309 REFEKSEK 1316
               ||:.|
Worm  1456 ---EKNRK 1460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	431/1331 (32%)
		ABC_membrane	94..360	CDD:294371	70/273 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	86/201 (43%)
		ABC_membrane	736..980	CDD:294371	69/266 (26%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	115/221 (52%)
mrp-8	NP_499598.2	CFTR_protein	173..1459	CDD:273530	438/1368 (32%)
		ABC_membrane	259..527	CDD:294371	70/273 (26%)
		ABCC_MRP_domain1	568..770	CDD:213217	90/224 (40%)
		ABC_membrane	887..1168	CDD:294371	78/295 (26%)
		ABCC_MRP_domain2	1219..1439	CDD:213211	115/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720