Protein Alignment CG31792 and Abcb1a

DIOPT Version :9

• Sequence 1: NP_001260548.1
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_035206.2
• Gene: Abcb1a / 18671
• MGIID: 97570
• Length: 1276
• Species: Mus musculus
• Alignment Length: 1422
• Identity: 327/1422 - (22%)
• Similarity: 562/1422 - (39%)
• Gaps: 368/1422 - (25%)

  Fly    53 RAESLGNKLCSSWANELETNKKNASLLRVLFRVFG---RYFVFLGLVLFCLEVILTVQPMFLMKL 114
            ||:...:|:......|.:..|...|:| .:||..|   |.::.:|    .|..|:....:.||.|
Mouse    10 RADKNFSKMGKKSKKEKKEKKPAVSVL-TMFRYAGWLDRLYMLVG----TLAAIIHGVALPLMML 69

  Fly   115 I--------SSFSNPSPTSNGV-------------------AYAYAGGVILGSALKVILMNPYSF 152
            |        :|..|.|..|..:                   ||.|.|   :|:.:.::.....||
Mouse    70 IFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTG---IGAGVLIVAYIQVSF 131

  Fly   153 AVTHLGLKIRVGVSSMIYRKCLRLTKT---------DLGEIST------GHIINLISNDLG---- 198
            .....|.:|.     .|.:|.......         |:||::|      ..|...|.:.:|
Mouse   132 WCLAAGRQIH-----KIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQ 191

  Fly   199 RMDTF-----IQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTF-----------------ILL 241
            .|.||     |.||.. |...|..|.::.::....||.|....:|                 :|.
Mouse   192 AMATFFGGFIIGFTRG-WKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLA 255

  Fly   242 FIPLQMYLGKKISGL-RLKTAIRSDKRMRIMTEIIAGIQV----IKMYA-WELPFEKMVAHARHK 300
            .|...:..|.:...| |....:...||:.|...|.|.|.:    :.:|| :.|.|....:....|
Mouse   256 AIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISK 320

  Fly   301 EINSIRHVAYAKCLIWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFS 365
            |              :|..:.||   :|.|    ||:|.|...:.:..|.|:.|   ....||..
Mouse   321 E--------------YSIGQVLT---VFFS----VLIGAFSVGQASPNIEAFAN---ARGAAYEV 361

  Fly   366 VGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNS 430
            ..:.....::.|..:      ||.   |.:|:..|
Mouse   362 FKIIDNKPSIDSFSK------SGH---KPDNIQGN------------------------------ 387

  Fly   431 EDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAIL-------GELRV 488
               :....:...:.:......|.|:||:|.:|..||:||::|.|||:.:|.:.       |.:.:
Mouse   388 ---LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSI 449

  Fly   489 ESGEI---------EVTGSMSYASQEPWLFSGTVRQNILFGQ---PMDR--------RRYDLVVR 533
            :..:|         |:.|   ..||||.||:.|:.:||.:|:   .||.        ..||.:::
Mouse   450 DGQDIRTINVRYLREIIG---VVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMK 511

  Fly   534 KCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDS---SVAR 595
                      ||.:..|::|:|||.||||||.||::||::.|:..|.|||:..||:|:   :|.:
Mouse   512 ----------LPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQ 566

  Fly   596 RLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESL-HKSGLDFGIVLDDPV 659
            ...::...|    :..|::.|:|..::.||.|...:.|.:...|.::.| .:.|:.|.:|:....
Mouse   567 AALDKAREG----RTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTA 627

  Fly   660 ND-----NEAAEDRSR----------TSSITDQRRSSVKSV---------LSHAESCPEDVGEEQ 700
            .:     |||.:.:..          :.|...:|||:.||:         ||..|:..|||....
Mouse   628 GNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPAS 692

  Fly   701 -----KINLQRQQLGRNGLGVYVDYFRAG-------GGFL-SFSVVMTFFVCSQGLASLGDYFLS 752
                 |:|           .....||..|       ||.. :|||:.:..|   |:.:.|.   .
Mouse   693 FWRILKLN-----------STEWPYFVVGIFCAIINGGLQPAFSVIFSKVV---GVFTNGG---P 740

  Fly   753 PWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMF 817
            |...|....:            |.:    :::::.::|.:....:.|.|.......:.:|...:|
Mouse   741 PETQRQNSNL------------FSL----LFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVF 789

  Fly   818 RGISRASMYFFN--KNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVN---- 876
            :.:.|..:.:|:  ||..|::..|.:.|..||.....:.:..:.|:....|..||:..|..
Mouse   790 KSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLT 854

  Fly   877 --PLFLIPALAF-GIV-IYYLRSFYLKTSLDVKRLEAS-----------------TRSPVY-SHF 919
              .|.::|.:|. |:| :..|....||   |.|.||.|                 ||...: :.:
Mouse   855 LLLLAIVPIIAIAGVVEMKMLSGQALK---DKKELEGSGKIATEAIENFRTVVSLTREQKFETMY 916

  Fly   920 AASL-----NGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIA-MI 978
            |.||     |.:.....||                     :..|.::|..|:....|..|.| ::
Mouse   917 AQSLQIPYRNAMKKAHVFG---------------------ITFSFTQAMMYFSYAACFRFGAYLV 960

  Fly   979 TLSFFIFPP-----SSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGP 1038
            |.....|..     |:.....:|:.|....          :.:.....:|...:|...|..||..
Mouse   961 TQQLMTFENVLLVFSAIVFGAMAVGQVSSF----------APDYAKATVSASHIIRIIEKTPEID 1015

  Fly  1039 LEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLI 1103
            ..:|...||:..   :|.::|..:...| |...|..||:.||..:|..:.:.:||.:|.|||:::
Mouse  1016 SYSTQGLKPNML---EGNVQFSGVVFNY-PTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV 1076

  Fly  1104 NALFRLSYND--GSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSD----- 1161
            ..|.|. |:.  |||.:|.|:...:.:..||:::.|:.|||:||..::..|:    .|.|
Mouse  1077 QLLERF-YDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENI----AYGDNSRVV 1136

  Fly  1162 --DRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATAN 1224
              :.:..|.:|..:...:.|:.....|::.:.|:..|.||:|.:.:|||::|...||::||||:.
Mouse  1137 SYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSA 1201

  Fly  1225 VDPQTDALIQATIRNKFRE-CTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELL 1280
            :|.:::.::|..: :|.|| .|.:.:||||.||.::|.::|:..|:|.|.||..:||
Mouse  1202 LDTESEKVVQEAL-DKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLL 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	327/1422 (23%)
		ABC_membrane	94..360	CDD:294371	71/339 (21%)
		ABCC_MRP_domain1	434..634	CDD:213217	66/229 (29%)
		ABC_membrane	736..980	CDD:294371	52/277 (19%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	72/230 (31%)
Abcb1a	NP_035206.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		3/15 (20%)
		PTZ00265	47..1263	CDD:240339	317/1384 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..681		8/34 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000