DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and mrp-3

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1386	Identity:	435/1386 - (31%)
Similarity:	691/1386 - (49%)	Gaps:	185/1386 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSNIFS-ALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELE------ 70
            |.|.:|..| .|..|:| .....|.:.||.|.|::....:...|.|..:..:.|..:.|
Worm   194 PEENANFISRQLLLWFT-QIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREKQ 257

  Fly    71 -----------TNKKNASLL---------------RVL--------------FRVFGRYFVFLGL 95
                       |..:.|.||               ||:              :.:.|..|
Worm   258 VKLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEILGGSF----- 317

  Fly    96 VLFCLEVILTVQPMFLMKLISSFSNP-SPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGL 159
            :.|..:::....|.||..||.....| :|..||:..|.  |:.|...:|.:.||.|..|:|.:|.
Worm   318 IKFLSDLLQFANPTFLNYLILFIETPNAPLINGIGLAV--GLFLAGQIKSLFMNTYFIAMTRVGA 380

  Fly   160 KIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLM 224
            ||:..:|..:|.|.|.|:.|...|.:.|.::|::|.|:.|...........|.:|.|.::...|:
Worm   381 KIQTMLSCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLL 445

  Fly   225 YQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELP 289
            .|.||:|...|:..::..:|:.:.:.......:|:.....|:|:|::.|::.||:|:|:.|||..
Worm   446 SQTIGVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETA 510

  Fly   290 FEKMVAHARHKEINSIRHVA----YAKCLIWSFNRFLTPVSIFL-SLVGFVLMG--RFLTAEVAF 347
            .|:.:...|.||:..|:..|    :|.||     ....||.:.| |...|||:.  ..||..:||
Worm   511 MEETIERVRDKELKMIKQSALLKTFADCL-----NVGAPVFVALSSFTVFVLIDPKNVLTPNIAF 570

  Fly   348 LITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREK 412
            :..:.:|::|..:.....: |.||.:.:||.|||:..|...||   |...:.       :|.|.:
Worm   571 VSLSLFNLLRGPLMMAAEL-VAQTVQLVVSNKRVRTFLCEKEV---DTAAID-------KEIRGE 624

  Fly   413 LLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSS 477
            |..                :.|.|......| .::....||.:.....:..||.:||..||||||
Worm   625 LYT----------------NTVEIHSGSFAW-DSAEARILSDIEFLAGSKELVTVVGSVGSGKSS 672

  Fly   478 LIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFE 542
            |:.|.|||:....|.:.|.||::|.||:||:.:.::::|:|....::...|..|:..|||:.|.:
Worm   673 LLLAALGEMEKVCGYVGVRGSVAYLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDLK 737

  Fly   543 LLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGH 605
            .||..|.|.:|::|.:|||||||||:|||:||:...:|.|||||||||:.|.:.:|:..:  .|.
Worm   738 QLPDGDDTEIGEKGINLSGGQKARIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNGM 802

  Fly   606 LRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESL---------------------HKSGL 649
            |.....||||:...|||::.:|::|:.|::|..|||..|                     ..||.
Worm   803 LSHTTRILVTNCTSFLQESGKIIVMKDGRIKHCGTYNELLTDVEAREYLQEVDNEYAQAQESSGE 867

  Fly   650 DFG-----IVLDDPVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQK----INLQ 705
            :.|     .:|...:.........||.|.|:  |:.|..|::           |::|    |..:
Worm   868 ESGGEENSDILPGSIASGSRMSRLSRLSKIS--RKKSKSSIV-----------EKKKPDALITKE 919

  Fly   706 RQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLG-DYFLSPWVSRNEKMVAHNYTTD 769
            ...:||...|||:.||:| .|.:::.:.....|......:|| ..:|:.|...|  :..::..|.
Worm   920 EAAIGRVNPGVYLLYFKA-MGIVTYVLPYAIAVVLNVSFALGRSLWLTAWSDAN--IDINHPDTM 981

  Fly   770 AKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAM------RASIQLHNSMFRGISRASMYFF 828
            :..|...::|.:        .|...|   ||||:|.:      .||..||..:...:.|..:.:|
Worm   982 SVGARLGVYAGF--------GITEVI---FLFFSLVLLLIGGVAASKNLHKPLLHNVLRNPLSYF 1035

  Fly   829 NKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYL 893
            :..|.|.|:||.:|||..||..|.:....::...:.....:::::...|||:...:...|:.:::
Worm  1036 DITPIGRIINRLAKDMEVVDLRLSSSFRFLVMALINMVQTVLIVSYTTPLFIAIIIPVFIIYFFV 1100

  Fly   894 RSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFIS 958
            ..:.:|::..::|:.:.||||::|:|:.:|.|:||:|||..........|.:.:.|...||....
Worm  1101 LKYSIKSTRQLQRIASLTRSPIFSNFSETLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQM 1165

  Fly   959 TSRAFAYWMD----------IFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQ 1013
            .:|    |:.          ||....:|:|.....|    :|..:||:::.::.:|..:...|||
Worm  1166 ANR----WLSIRLELLGNIVIFSAAILAIIGKESGI----TAGMLGLSVSYSLNITFMLNMFVRQ 1222

  Fly  1014 SAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKS 1078
            ..|:|..::||||:.||.:.:.|.......:..| .:||..|.:...:.|.||...|  :.|||.
Worm  1223 INEVETNVVSVERIDEYSKTKSEAEWRLDNNNLP-SNWPTGGAVNIEDYSCRYRDEL--DLVLKQ 1284

  Fly  1079 LSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEP 1142
            :|..|.|.:|||:.||||||||||..||||: ...||::.||...|:.:||||||.|::|||||.
Worm  1285 ISLNILPGQKVGVCGRTGAGKSSLALALFRIVEAADGNISIDQTITSHIGLHDLREKLTIIPQEN 1349

  Fly  1143 VLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLAR 1207
            |||:.|:|.|:||..:::|.:||.|||...||..|..:...||:.:.|||.|||||||||:||.|
Worm  1350 VLFANTLRFNIDPKGQFTDQQLWLALENSNLKAHVELLPHKLESPVAEGGENFSVGQRQLLCLTR 1414

  Fly  1208 AILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVE 1272
            |:||.:::||:|||||.:|.:||.::|||||.||.:.|::|:|||||||:|.||::||||||:||
Worm  1415 ALLRKSKVLVLDEATAGIDNRTDTMVQATIREKFADSTIITIAHRLHTIIDYDRIIVMDAGRIVE 1479

  Fly  1273 FGTPYELLTADDTNAFQDLVK 1293
            .|.|.||| .:..:.|..|.|
Worm  1480 DGIPGELL-KNRNSQFYGLAK 1499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	431/1372 (31%)
		ABC_membrane	94..360	CDD:294371	78/273 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	80/201 (40%)
		ABC_membrane	736..980	CDD:294371	62/260 (24%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	120/221 (54%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	435/1386 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720