DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and mrp-5

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_510479.1	Gene:	mrp-5 / 181587	WormBaseID:	WBGene00003411	Length:	1427	Species:	Caenorhabditis elegans

Alignment Length:	1349	Identity:	432/1349 - (32%)
Similarity:	699/1349 - (51%)	Gaps:	92/1349 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSALSFWYTIPTFIKGQKVTLGAKDLYR-------ALKEHRAESLGNKLCSSWANELETNKK 74
            :.:||.:::.:..|...:..:..|....::.       .|...|.|.|       |.:|.:.|.|
Worm    73 AGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARLEVL-------WEDEKKANAK 130

  Fly    75 NASLLRVLFR-VFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPS-PTSNGVAYAYAGGVI 137
            :.||.:|::| :..|.:....:..|||.........|:.:||:...||. ...:.:.|:|  |:.
Worm   131 SPSLFKVIYRFISTRLWFSCAVFFFCLIFGFIGPTCFIRRLIAFAENPERDEQSRIVYSY--GIA 193

  Fly   138 LGSALKV-----ILMNPYSFAVTH-LGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISND 196
            |.:|:.|     :|....::||:: .|:::|..|.:::|:..  |...||...:...:||:.:||
Worm   194 LVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNV--LNSKDLCGKTESDVINIFAND 256

  Fly   197 LGRMDTFIQFTHYLWLAPLQAL-MVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKT 260
            ..|:...:.|...:.:.||..: .:.||: ..||..::.|:....:|..:|..|||.:...|...
Worm   257 GQRLFDAVTFAPLVLVGPLVLVGGIGYLL-MVIGRWSLLGILVFFVFDVIQFGLGKSMVACRNLA 320

  Fly   261 AIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPV 325
            .::::||:.:|.|||..|:::||..||..|...:...|.:|...||...||:.|..:....:..|
Worm   321 IVKTEKRISMMAEIIKYIRIVKMNGWEQIFSAKIDQFRKEEKVQIRKSGYAQSLAIACGPVVPVV 385

  Fly   326 SIFLSLVGFVLMGRFLTAEVAF-LITAYYNVV-RTNMTAYFSVGVTQTAETLVSIKRVQKLLLSG 388
            :..|:.||.||.|..|.|..|| .||.|:.:: ...|..|   |....||.:|:::|:|:.||..
Worm   386 AAILTFVGVVLAGNDLLASDAFSAITVYFVMLFGIRMIPY---GSRYLAEAVVAMRRIQEYLLLE 447

  Fly   389 EV----VAKDENVV--SNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNS 447
            :.    |...|:||  ..||....|....|..|..|      |.|..:|..|          ..:
Worm   448 QYAPYPVTNAEDVVLDCQGATYTYQPKAAKAPVDET------KEPTENEVIV----------VET 496

  Fly   448 PDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMS-YASQEPWLFSG 511
            |.:|.|...|.:..|..:|::|..|.|||::::||.|.:......:.|..|.: |..|:.|:|:|
Worm   497 PVFTCSFDKLSIKRGEHIAVIGAVGCGKSAILKAISGHMFTTDDALSVDRSQTVYVPQKAWIFNG 561

  Fly   512 TVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRD 576
            ||:.|||||..|:..||...|..|.|..|...|.:.|:|.:|:|||:||||||||::|||:|::.
Worm   562 TVQDNILFGDKMNSERYYKAVNGCQLTEDLTTLSVGDRTEVGERGATLSGGQKARVALARAVFQT 626

  Fly   577 ASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY 641
            .::||.||..:::|..||.::.||.::..|:.|.:::||:.::.|...|:::.:|.|.:.|.|.:
Worm   627 KNLYLFDDIFASLDKKVANKIHEEIIQKLLKKKALMMVTNNMELLHHFDRVLFVEGGNIVADGNH 691

  Fly   642 ESLHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITD-------QRRSSVKSVLSHAESCPEDV-GE 698
            :.|::....:...:|       |.|....||..|.       |.......:|.::.   ||: |:
Worm   692 DILYEKNDAYKTFVD-------ACETYQATSGATSPCGDGPAQPAPLDAEILRNSS---EDLKGD 746

  Fly   699 EQKINLQRQQLGRNGLG--VYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSR--NE 759
            ..|:....:.:|.:.:.  :|..|..|.||:..::.::..|:.:........|:||.|:.:  :|
Worm   747 ADKLISDEEDMGNSTIAWRIYKQYIHAAGGWPIWTCLVIGFIVNVVSNIFSTYWLSRWLKKGHDE 811

  Fly   760 KMVAHNYT------TDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFR 818
            .....|.|      |...|:......|.:|::..|:..:..:.::.:|..:::.|:.:||:.||:
Worm   812 TTTITNGTEFLEMKTSLADSPVTGFYAAVYLVALVVLTISGLFKACVFVKVSLTAATRLHDRMFQ 876

  Fly   819 GISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPA 883
            .:...:..||:..|.|.|||||||||.::|..||......:|:.:...|.::||..|.|.||:.|
Worm   877 AVIHGATSFFDSTPTGRILNRFSKDMDEIDVKLPFTAEVFLQNMITCLGFLVVITSVFPYFLLFA 941

  Fly   884 LAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDM 948
            :...:|.....|.:.....::||.|..:|||:|.|.:|||.|::||..|...:........:.|.
Worm   942 IPLFVVFVVFVSCFRAGIRNLKRSEHISRSPLYDHVSASLEGITTIHTFQQSNRFLEVLKKHLDC 1006

  Fly   949 HSSASYMFISTSRAFAYWMDIFCVLFIAMIT-LSFFIFPPSSAADVGLAITQAMGLTGTVQWTVR 1012
            :|.|.:||.|..|..|.|:|:..|:..|::. |:..:....|.||.|:||..|:.::|..|:.||
Worm  1007 NSGAIFMFQSAMRWLAVWLDLLVVVMTAIVALLTVMLTGTVSPADAGMAIAFAVQMSGIFQFAVR 1071

  Fly  1013 QSAELENTMISVERMIEYEEIEPE-GPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESV- 1075
            ...|||..|.||||:..|.:..|| |............|||..|:|.|.|::|||.   ||..:
Worm  1072 TQTELEAKMTSVERVSYYADNIPEDGEWNTRQGLDIESSWPANGQINFSEVNLRYR---KSHPLA 1133

  Fly  1076 LKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIP 1139
            |..::|.||..|||||:||||:|||||.|.:||| ...:|::.||..|...:||..||..||.|.
Worm  1134 LNDITFEIKGGEKVGIIGRTGSGKSSLANLIFRLYPVTNGTIYIDGVDIRTVGLVKLRRGISAIA 1198

  Fly  1140 QEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVC 1204
            |:|.|||||||.||||..||||..:|.|||:..||.:|.|:...||..::.||:|||||:|||.|
Worm  1199 QDPSLFSGTVRFNLDPSLEYSDSMIWEALEKCHLKTLVQSLDKKLEADVSHGGNNFSVGERQLFC 1263

  Fly  1205 LARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGR 1269
            ||||:|..:||:::|||||:||..||.|||..|:..|.:.||:.:||||..:.:.||::.:..|:
Worm  1264 LARALLMKSRIVILDEATASVDAGTDKLIQEVIKTVFADATVIIIAHRLDNVRNMDRIMHLKNGK 1328

  Fly  1270 VVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKPS 1318
            ::.|.||.|:. .||.:.::...|...|.:...:.:.|:...|||.:.|
Worm  1329 LINFTTPQEMF-KDDWSVYKLEDKDDDQHSAVVVGENSEHSMEKSSQGS 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	423/1310 (32%)
		ABC_membrane	94..360	CDD:294371	76/275 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	71/200 (36%)
		ABC_membrane	736..980	CDD:294371	73/252 (29%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/222 (50%)
mrp-5	NP_510479.1	MRP_assoc_pro	90..1340	CDD:188098	420/1294 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	142	1.000	Domainoid score	I2904
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1827
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.780