DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and pgp-4

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001257142.1	Gene:	pgp-4 / 181327	WormBaseID:	WBGene00003998	Length:	1280	Species:	Caenorhabditis elegans

Alignment Length:	1430	Identity:	324/1430 - (22%)
Similarity:	575/1430 - (40%)	Gaps:	355/1430 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNASLLRVLFRVFG--RYFV 91
            :|..|..:.|.||:          |.:....|..||..|.|..          |||..|  .|.:
Worm    13 VPMKIASEHVELGS----------RPDKKKKKSRSSQGNSLSN----------LFRHSGCADYLL 57

  Fly    92 FL-GLVL------------FCLEVILTVQPMFLMKLISSFSNPS----PTSNGVAYAYAGGVILG 139
            .| ||||            ...|.|..|    |||..:.:.|.:    ..|:|:.:......:||
Worm    58 LLGGLVLSAANGALLPFNSLIFEGITNV----LMKGEAQWQNGTFDYDTFSSGIQHYCLLYFLLG 118

  Fly   140 SALKVILMNPYSFAVTHLGLKIRVGVSSMIYRK--CLR------LTKTD---LGEISTGHIINLI 193
                 :||    |..|:..   ...:.:|..|:  |:|      :.:.|   ..|.:.|.:...:
Worm   119 -----VLM----FTCTYFS---NACLFTMAERRLYCIRKHLLQSVLRQDAKWFDENTVGGLTQKM 171

  Fly   194 SNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLF-IPLQ---MYLGKKIS 254
            |:.:.::...|...    :..|.:.:.|::....:|....:.:|.::|. :|||   |||..|
Worm   172 SSGIEKIKDGIGDK----IGVLVSGIATFISGVALGFYMCWQLTLVMLVTVPLQLGSMYLSAK-- 230

  Fly   255 GLRLKTAIRSDKRM-----RIMTEIIAGIQVIKMYAWELPFE-----KMVAHARHKEINSIRHVA 309
              .|..|.:::...     .:..|:||||:.:..:..: |||     ..:|.||...|.  :.:.
Worm   231 --HLNRATKNEMSAYSSAGGMANEVIAGIRTVIAFNAQ-PFEIERYGAQLAKARKMGIR--KAIV 290

  Fly   310 YAKCLIWSFNRFLTPVSIFLSLVGFVLM-GRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAE 373
            .|.|         :.:.:||.   |||| |.|           :|..:.|      |.||..:..
Worm   291 LALC---------SAMPLFLM---FVLMAGAF-----------WYGAILT------SYGVATSGT 326

  Fly   374 T-------LVSIKRVQKL-----LLSGEVVAKDE--NVVSNGAEEDL--QEARE------KLLVT 416
            |       ::..:|:.:.     .::|..:|.::  .|:.:..|.:.  ||.|.      ||:..
Worm   327 TFGVFWAVILGTRRLGEAAPHMGAITGARLAVNDIFKVIDHEPEINCTKQEGRRPDKVNGKLVFD 391

  Fly   417 PTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQA 481
            ......|.:|           ::|          .|.||:.:|:.|..:|:|||:|.|||:.|..
Worm   392 NIQFTYPTRP-----------DVK----------ILKGVSFEVNPGETIALVGHSGCGKSTSIGL 435

  Fly   482 IL-------GELRVESGEIE------VTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVR 533
            ::       |.::::...||      :..::....|||.:|..||.:|:..|.       |.:..
Worm   436 LMRFYNQCAGSIKLDGIPIEDYNIQWLRSTIGIVQQEPIIFLATVAENVRMGD-------DSITD 493

  Fly   534 K-----C--ALERDFELLPLKD--KTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAV 589
            |     |  |...|| :..|.:  .|::|.....||||||.|:::||::.|...|.|||:..||:
Worm   494 KDIENACRQANAHDF-IGKLSEGYNTVIGAGAVQLSGGQKQRVAIARAIVRKPQILLLDEATSAL 557

  Fly   590 DSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESL-HKSGLDFGI 653
            |:. :.|:.:..|......:..:.:.|:|..::.|.:|::.:.|.:...|.::.| .::|:...:
Worm   558 DTE-SERMVQTALDKASEGRTTLCIAHRLSTIRNASKILVFDQGLIPERGIHDQLIRQNGIYANM 621

  Fly   654 VL---------DDPVNDNEAAED----------------RSRTSSITDQRRSSVKSVLSHAESCP 693
            |.         |...:|:|..|:                |...|.:.|..|.| :|:||.....|
Worm   622 VRAQEIEKAKDDTTQDDDELVEEDNYSISRRLSTSEEELRKSKSLLRDSTRFS-QSMLSVTSQVP 685

  Fly   694 EDVGEEQKINLQRQQLGRNGL--GVYVDYFRAGGGFLSFSVVMTFFVCSQGL------ASLGDYF 750
                 :.::...|:::...|.  ...:|.||.........|:...|...:|:      ...|..|
Worm   686 -----DWEMESAREEMIEEGAMEASMMDIFRFAKPEKMNIVIALIFTLIRGITWPAFSVVYGQLF 745

  Fly   751 LSPWVSRNEKMVAHNYTTDAKDADFEMHA---AYIYMLITVLSIMVTIKRSFLFFNLAMRASIQL 812
                     |:.|..      ..|..::|   :..::|:.|.|.:.|.....|........|.:|
Worm   746 ---------KVFAEG------GEDLPVNALISSLWFVLLAVTSAVTTFISGSLLGKTGETMSSRL 795

  Fly   813 HNSMFRGISRASMYFFN--KNPAGSILNRFSKD----MGQVDEMLPTIIMTVIQDF------LLF 865
            ...:|:.|.:....:|:  |:..|::.:|.:.|    ...:|..|..::..|:..|      ..|
Worm   796 RMDVFKNIMQQDATYFDDPKHNVGNLTSRLATDSQNVQAAIDHRLAEVLNGVVSLFTGIAVAFWF 860

  Fly   866 GGNIIVIAIVNPLFLIPALAFGIVIYYLRSFY-----LKTSLDVKRL-----------EASTRSP 914
            |.::..|.::..|.|:  :|...|..||:  |     ::::::..|:           :|.|:..
Worm   861 GWSMAPIGLITALLLV--IAQSAVAQYLK--YRGPKDMESAIEASRIVTESISNWKTVQALTKQE 921

  Fly   915 VYSH--FAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAY----------WM 967
            ...|  .|||.|...  |||..|.        :|.:..:.:..|...:.|.||          |.
Worm   922 YMFHAFTAASKNPRK--RAFTKGL--------WQSLSFALAGSFFLWNFAIAYMFGLWLISNNWT 976

  Fly   968 DIFCVLFIA----MITLSFFI----FPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISV 1024
            ..|.|..:.    |.::|..:    ||....|.:...|...|         :||.|:::|..::.
Worm   977 TPFAVFQVIEALNMASMSVMMAASYFPEYVRARISAGIMFTM---------IRQKAKIDNRGLTG 1032

  Fly  1025 ERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKV 1089
            |                |.|.:        |.|....:...| |....:.:|.:.:...:..|.|
Worm  1033 E----------------TPDIR--------GDISMKGVYFAY-PNRNRQLILNNFNMSAQFGETV 1072

  Fly  1090 GIVGRTGAGKSSLINALFRLSYND---GSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRH 1151
            .:||.:|.|||:.|..:.|  |.|   |:|:|||.|..|:.:..||..|:::.|||.||:.|:|.
Worm  1073 ALVGPSGCGKSTSIQLIER--YYDAICGAVKIDDHDIRDISVKHLRHNIALVGQEPTLFNLTIRE 1135

  Fly  1152 NLD-PFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRI 1215
            |:. ..:..|.:::..|.....:...|.::..|.:|.:...|...|.||:|.:.:||||:|:.:|
Worm  1136 NITYGLENVSQEQVEKAATLANIHSFVENLPEGYDTSVGASGGRLSGGQKQRIAIARAIVRNPKI 1200

  Fly  1216 LVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELL 1280
            |::||||:.:|.:::.::|..:.......|.:.:||||.||.::|:::|...|:.:|.||...||
Worm  1201 LLLDEATSALDTESEKIVQEALDKARLGRTCVVIAHRLSTIQNADKIIVCRNGKAIEEGTHQTLL 1265

Fly 1281 1280
Worm 1266 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	324/1430 (23%)
		ABC_membrane	94..360	CDD:294371	66/307 (21%)
		ABCC_MRP_domain1	434..634	CDD:213217	58/221 (26%)
		ABC_membrane	736..980	CDD:294371	57/296 (19%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	70/224 (31%)
pgp-4	NP_001257142.1	ABC_membrane	65..338	CDD:279056	66/328 (20%)
		PTZ00265	68..1276	CDD:240339	303/1355 (22%)
		ABC_MTABC3_MDL1_MDL2	389..625	CDD:213216	65/265 (25%)
		ABC_membrane	724..993	CDD:279056	57/297 (19%)
		ABC_MTABC3_MDL1_MDL2	1041..1278	CDD:213216	72/228 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910