Protein Alignment CG31792 and pgp-6

DIOPT Version :9

• Sequence 1: NP_001260548.1
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_001041287.2
• Gene: pgp-6 / 181278
• WormBaseID: WBGene00004000
• Length: 1263
• Species: Caenorhabditis elegans
• Alignment Length: 1362
• Identity: 318/1362 - (23%)
• Similarity: 577/1362 - (42%)
• Gaps: 274/1362 - (20%)

  Fly    77 SLLRVLFR---VFGRYFVFLGLVL-----FCLEVILTVQPMF----------LMKLISSFSNPS- 122
            |.:||:|:   .|.::...||::.     ||       ||..          |:.:.::.:|.:
 Worm    26 SFIRVVFKCSSCFEKFLFLLGVLFSLMTGFC-------QPFMSYTFGEVSQVLVTITNAINNKTI 83

  Fly   123 -PTSNGVAY-AYAGGV--------ILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYR----KC 173
             |.....|| .|..|:        :.|.|.       :.||.....:...|| .:..||    ..
 Worm    84 DPADLEKAYEEYERGMNQVVFHFFLCGCAY-------FIFASLQHAIMKYVG-DNTTYRVRKQYI 140

  Fly   174 LRLTKTD---LGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFG 235
            .||.|.|   ...:||||:..:::::|.|....  |...:      ||::.::....:|.|..|.
 Worm   141 SRLLKKDAQYFDSVSTGHLSTVLNDNLERFREV--FNEKI------ALIIAFVTDFTLGTALAFY 197

  Fly   236 MTFILLFIPLQMYLGKKISGL-----RLKTAIRSDKRMRIMTEIIAGIQVIKMY--AWELPFEKM 293
            ..:.|....:...||...||.     .:||..:.:........|  ..|.:..|  ...|..:|.
 Worm   198 TDWRLASYGIFFSLGIAFSGFINSAGVMKTTGKQNTHYANAGSI--AFQTLGAYKTVCSLNGQKT 260

  Fly   294 VAHARHKEINSIRHVAYAKCLIWSFNR-----FLTPVSIFLSLVG--FVLMGRFLTAEVAFLITA 351
            ......:|:.:.......:.|::|.:|     |...::..:..||  .:..|   |.|.|.::..
 Worm   261 EIERYTEELKAGEKYGIRRALMYSISRGVTYFFCNSLNTVVLYVGATMIYSG---TLETAVVVRL 322

  Fly   352 YYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLS----GEVVAKDENVVSNGAEEDLQEAREK 412
            ::         |...|....:|.|..|.|:...:.|    .|::.||:||:    |:|..:...:
 Worm   323 FH---------YMLFGAFCLSEALPHISRLAGAISSTAPIAEMLIKDDNVI----EKDETDYDVE 374

  Fly   413 LLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSS 477
            :.|...               :|...:|..:.|......|.|::..|..|..:|:||.:|||||:
 Worm   375 VEVNGN---------------ISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKST 424

  Fly   478 LIQAILGELRVESGEIEVTGS-------------MSYASQEPWLFSGTVRQNILFGQP------- 522
            ::|.:|....::||.|.:.|.             :...||||.||:.|:.:||.||.|
 Worm   425 VVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEI 489

  Fly   523 ----MDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLD 583
                .....||.|   |:       .|...|||:|:||..||||||.||::||::.|:..|.|||
 Worm   490 YGALRKANAYDFV---CS-------FPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLD 544

  Fly   584 DPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESL-HKS 647
            :..||:|:. :.::.::.|....:.:..|:|.|:|..::.|.:|::|:.|::..||.::.| .|.
 Worm   545 EATSALDNE-SEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKR 608

  Fly   648 GLDFGIVL-------DD-----PVNDNEAAEDRSRTSSITDQRRSSVKSVL--SHAESCPEDVGE 698
            |:...:|.       ||     |:...:.:::.|...|...||.:|..:.:  ...|...:::.:
 Worm   609 GVYNDLVQAQLLESHDDHEELPPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSK 673

  Fly   699 E--QKINLQR--QQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCS-QGLASLGD---YFLSPWV 755
            |  :|.||:.  :|...:...:::..|.:....:|:.::....|.: :|.|.:|:   |:...|
 Worm   674 EGAKKSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAMIGEDMLYYSHLW- 737

  Fly   756 SRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGI 820
                                    |..:|.:.|...:....:.:.|..::.:.|.:|....|..:
 Worm   738 ------------------------ALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHM 778

  Fly   821 SRASMYFFN--KNPAGSILNRFSKDMGQ----VDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP-- 877
            ......|::  .:.|..:.||.:.|...    ||:.|..:||||:         .|.|||...
 Worm   779 LSLPCAFYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVV---------AISIAITTASL 834

  Fly   878 ---LFLIPALAFGIVIYYLRSFY---LKTSL--DVKRLEASTRSPVYSHFAASLNGLSTIRAFG- 933
               ...:..|.|..::|.....|   .:|::  |....|.|.|:.:     .:|..:.|:||..
 Worm   835 YCWKMTLEVLMFFPLLYLAEYCYEAATETAIQEDTIAFENSNRTAI-----EALENVRTVRALNL 894

  Fly   934 AGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAIT 998
            ...|:....:..|.:|.  ||...:..:..|..:.:.|.||:..::..|..:         ||:.
 Worm   895 EDKIMSLISEHLQKIHK--SYFKRAIIQGAANGLSLSCFLFVYSVSFKFGTY---------LALR 948

  Fly   999 QAMGLTGT--VQWTVRQSAELENTMISVERMIEYEE-IEPEG------------PLEATADKKPH 1048
            :.:....|  |..|:..:|.:..:  :...:.:|:: :...|            |..::..||.
 Worm   949 KEVAPMDTYLVLMTLSMTANMAGS--AAAYLPDYKKAVHAAGLIFHLFTYPATMPFSSSDGKKN- 1010

  Fly  1049 ESWPEQGKI--EFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSY 1111
               .|:|:|  |.|:......|   ...:|..::..:.|.:.:.:||.:|.|||::|:.|.|..:
 Worm  1011 ---IEKGEIIGENVQFHYDQRP---DRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYH 1069

  Fly  1112 N-DGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDR------LWCALE 1169
            . ||.|:||.::..|:.|:.|||.::::.|||.||:.::|.||    .|...|      |..||:
 Worm  1070 AVDGEVKIDSENVEDINLNHLRSNLALVSQEPTLFNCSIRENL----LYGLTRSVPQLELEKALQ 1130

  Fly  1170 EVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQ 1234
            .....:.|.....||:|.:.|.|:..|.||:|.:.:||||||:.::|::||||:.:|..::.::|
 Worm  1131 TANAFNFVFQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQ 1195

  Fly  1235 ATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTG 1296
            ..:.......:.:.|||||.|::::|.:.|:..|:|.|.||..|||.  ..:.:..||::.|
 Worm  1196 NALDTASERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR--KRSIYWRLVQKQG 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	314/1345 (23%)
		ABC_membrane	94..360	CDD:294371	59/312 (19%)
		ABCC_MRP_domain1	434..634	CDD:213217	70/223 (31%)
		ABC_membrane	736..980	CDD:294371	51/264 (19%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	74/229 (32%)
pgp-6	NP_001041287.2	PTZ00265	32..1252	CDD:240339	313/1351 (23%)
		ABC_membrane	47..331	CDD:294371	60/320 (19%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	77/247 (31%)
		ABC_membrane	699..970	CDD:279056	60/320 (19%)
		ABC_MTABC3_MDL1_MDL2	1019..1254	CDD:213216	78/243 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910