Protein Alignment CG31792 and pgp-5

DIOPT Version :9

• Sequence 1: NP_001260548.1
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_001257116.1
• Gene: pgp-5 / 181276
• WormBaseID: WBGene00003999
• Length: 1252
• Species: Caenorhabditis elegans
• Alignment Length: 1364
• Identity: 324/1364 - (23%)
• Similarity: 596/1364 - (43%)
• Gaps: 245/1364 - (17%)

  Fly    63 SSWANELETNKKNASLLRVLFRVFGRY---FVFLGLVLFCLEVILT--VQP----------MFLM 112
            ::|:|.       ...::|:.:...||   ..|||:|.    .|||  .||          ..|:
 Worm    13 TNWSNV-------CKFIKVIIKCTTRYEKLLFFLGVVF----SILTGMCQPFESYTLGETSQVLV 66

  Fly   113 KLISSFSNPSPTSNGVAYAYAGGVILGSALKVILM------NPYSFAVTHLGLKIRVGVSSM--I 169
            |:.::.:|.:.....:|:||.  :......:|:|:      ..::|......:...||.::.  :
 Worm    67 KVTNAINNKTIDPVDLAHAYK--LFESDMNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNV 129

  Fly   170 YRKCL-RLTKTDLG---EISTGHIINLISNDLGRMDTFIQ-FTHYLWLAPLQALMVTYLMYQEIG 229
            .|:.: ||.:.|:.   .:|||| ::::.||  .|:.|.: |...:      ||::..|....||
 Worm   130 RRQYISRLLRKDISYFDGMSTGH-LSIVLND--NMERFREVFNEKI------ALIIALLTDFVIG 185

  Fly   230 IAAVFGMTFILLFIPLQMYLGKKISGL-----RLKTAIRSDKRMRIMTEIIAGIQVIKMY--AWE 287
            ....|...:.|.........|..:|||     ::|...:.::.:.....|  ..|.:..|  ...
 Worm   186 TILAFYTDWRLACYGTVFSFGIVLSGLLDSWGKMKNNEKQNEHISNAGSI--AFQALGCYKTVSS 248

  Fly   288 LPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAY 352
            |..::.......:|:.:....|..:..::|.:|  :....|.:.:.||::  :..|.:.:..|..
 Worm   249 LNGQQQEVERYTEELKNGEKYALNRAFVFSLSR--SADYFFTNALNFVIL--YFGANMIYEGTIE 309

  Fly   353 YNVVRTNMTAYFSVGVTQTAETLVSIKR----------VQKLLLSGEVVAKDENVVSNGAEEDLQ 407
            ..|| ..:..|...|.....|.::.|.|          :..:||..:..| ||..     .|:::
 Worm   310 PGVV-VRILYYILFGSYCLGEAILHISRLASAIPLTVPIADILLDSDATA-DEFF-----SEEIK 367

  Fly   408 EAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTG 472
            :..:.:                    :|...:...:.|......|..::..|..|..:|:||.:|
 Worm   368 DTFQGI--------------------ISFKNVLFSYPTRPDVPVLKEISFNVQGGECIALVGASG 412

  Fly   473 SGKSSLIQAILGELRVESGEIEVTG-------------SMSYASQEPWLFSGTVRQNILFGQPMD 524
            ||||::||.:|....::||.|.:.|             :|....|||.||:.::.:||.||:| |
 Worm   413 SGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVVFQEPVLFNTSIEENIRFGKP-D 476

  Fly   525 RRRYDLV-VRKCALERDFEL-LPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLS 587
            ....::: ..|.|...||.. .|...|||:|:|||.||||||.||::||::.|:..|.|||:..|
 Worm   477 ATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQRIAIARTLVRNPRILLLDEATS 541

  Fly   588 AVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESL-HKSGLDF 651
            |:|:. :..:.:|.|:.....:..|:|.|:|..::.|::|::||.|::..||.::.| ..:|:..
 Worm   542 ALDNE-SEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEKGEIVEVGDHKQLIAMNGVYN 605

  Fly   652 GIVLD-------DPVNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKI-NLQRQQ 708
            .:|..       :.:|:||  |..:|.||.:|...:.:    ||.:...||...::.| .::.:.
 Worm   606 NLVQTQLMSTNYEKMNENE--ERVTRQSSHSDFPSNEI----SHQKIDQEDDYVKKLIAEIKEEG 664

  Fly   709 LGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDA 773
            ..::.:...:.|.|        |.....|:...|.|..|.|:     ..:.:::..:|...|.|.
 Worm   665 AKKSNICEIIKYCR--------SEYCILFIAVLGSAIQGIYY-----PLSSQLMIKSYEAYAFDK 716

  Fly   774 DFEMHAAYIYMLITVLSIMVTIKRSFLFF------NLAMRASIQLHNSMFRGISRASMYFFNK-- 830
            | ||.:...:..:::|.:..| :..|:||      ..|.:.||:|.:..|:.:......|::.
 Worm   717 D-EMLSKSHFWALSILFLAFT-RPIFIFFQYYFFGKTAEKLSIKLRSMSFKHLMSLPCAFYDDPC 779

  Fly   831 NPAGSILNRFSKDMGQ----VDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFL-----IPALAF 886
            :.|..:.||.:.|...    ||:.|.::|||::         .|::|::...|.     :..|.|
 Worm   780 HTATRLSNRLNADSSNVTAAVDDRLGSVIMTLV---------AILLAVIMSFFYSWKMSLQVLMF 835

  Fly   887 GIVIY---YLRSFYLKTSL--DVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGS--IL------ 938
            ..::|   |....::..::  |....|.|.|:.:     .:|..:.|:||....:  ||
 Worm   836 CPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAI-----EALENVRTVRALNMENRVILLVTSHL 895

  Fly   939 ---------EAEFDGYQDMHSSASYMFI-STSRAFAYW---------MDIFCVLFIAMITLSFFI 984
                     .|...|..:..:.:.|.|| :.|..|..|         ||.:.||....:|.|:..
 Worm   896 QKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLVLMTLSMTASYAG 960

  Fly   985 FPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHE 1049
            ...:...|...|| .|.||                    :..:..|..|.|....:...:.|
 Worm   961 SAVAYLPDHRKAI-HAAGL--------------------IFHLFTYPAIMPYDSSQGKRNIK--- 1001

  Fly  1050 SWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN-D 1113
                .|:||...:|..| .....:.:|..:|..:.....:.:||.:|:|||::|:.|.|..:. |
 Worm  1002 ----NGEIELKNVSFEY-AQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVD 1061

  Fly  1114 GSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWC--ALEEVELKDV 1176
            |.|:||:::..|:.||.||..:|::.||||||:.:::.|......::..:|..  ||:.......
 Worm  1062 GEVKIDEENVVDVNLHHLRESVSLVSQEPVLFNCSIKENFLFGISHNASQLEIDQALKVANAFSF 1126

  Fly  1177 VASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKF 1241
            |:....||:|.:.|.|:..|.||:|.:.:||||||:.::|::||||:.:|..::.::|..:....
 Worm  1127 VSQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTAS 1191

  Fly  1242 RECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLK 1305
            ...:.:.|||||.|::::|.:.|:..|:|.|.||..|||.  ..:.:..||::.| ...:||::
 Worm  1192 ERLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLR--KRSIYWRLVQKQG-IQVETLIE 1252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	318/1338 (24%)
		ABC_membrane	94..360	CDD:294371	58/297 (20%)
		ABCC_MRP_domain1	434..634	CDD:213217	72/214 (34%)
		ABC_membrane	736..980	CDD:294371	61/292 (21%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	72/223 (32%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	317/1329 (24%)
		ABC_membrane	41..322	CDD:294371	58/302 (19%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	78/238 (33%)
		ABC_membrane	688..955	CDD:294371	60/287 (21%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	77/240 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000