DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and mrp-1

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1388	Identity:	459/1388 - (33%)
Similarity:	714/1388 - (51%)	Gaps:	155/1388 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLPEN--------PRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCS 63
            |.|.|        |...::..:.|:| |::...:: |.|.:|..:||:...:..:||::......
Worm   195 DTPSNGYIGKNSCPEYTASFLNQLTFQWFSGLAYL-GNKKSLEKEDLWDLNERDKAENIIPSFIE 258

  Fly    64 SWANELE-------------TNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLI 115
            :...|:|             ..|.:.|:|..:|:.:....:..|......:::..|.|..|.:||
Worm   259 NLIPEVEGYRRKIKKNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLI 323

  Fly   116 SSFSNPS-PTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKT 179
            |...:.: |...||:.|..  :.|.|.|:.::::.|...:..||:.||..::|.:|.|.|.|:..
Worm   324 SFIEDKNQPMWIGVSIALL--MFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNE 386

  Fly   180 DLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIP 244
            .....:||.|:||:|.|:.|:.....|....|.||||.|:..|.:::.:|::.:.|...::|.||
Worm   387 ARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIP 451

  Fly   245 LQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVA 309
            ...::..|:...:::.....|:|:::|:||:.|::|:|:|:||...||||...|.|||..::.::
Worm   452 FNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLS 516

  Fly   310 Y---AKCLIWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQT 371
            |   |..|.|:...||..|..|...|.:......||.::.|:..|.:|::|..: |.|::..:|.
Worm   517 YLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPL-AVFAMVFSQA 580

  Fly   372 AETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSI 436
            .:...|..|: |...:.|.::...::...|                            ::..:.:
Worm   581 VQCSASNTRL-KEFFAAEEMSPQTSIAYGG----------------------------TDSAIKM 616

  Fly   437 SELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSY 501
            ......|.:...|..|..:...:..|.||||||..|||||||:.|:|||:...||.::|.||::|
Worm   617 DGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAY 681

  Fly   502 ASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKAR 566
            ..|..|:.:.::|.||||.:|.|.:.|..|:..|||.:|.|.||.:|:|.:|::|.:||||||.|
Worm   682 VPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQR 746

  Fly   567 ISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL---RGHLRDKIVILVTHQLQFLQQADQIV 628
            :||||:||::|.|.|||||||||||.|.:.:||..:   .|.|..|..:|:||.|.:|:..||::
Worm   747 VSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVI 811

  Fly   629 IMEMGKVKAVGTY--------------------ESLHKS-GLDFGIVLDDPVNDNEAAEDRSRTS 672
            :::...:..:|||                    ||.||. .:.||   :|....||...|..:.|
Worm   812 VLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFG---EDSKEVNELLRDLDQVS 873

  Fly   673 SITDQR----------------------------------------RSSVKSVLSHAESCPEDVG 697
            ....||                                        :.|:...:|..|..||...
Worm   874 PAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPK 938

  Fly   698 E--EQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFF---VCSQGLASLGDYFLSPWVSR 757
            :  .|.|..:..:.|:....||:.||||    :...:.:.||   |.|..|....:.:|:.| |.
Worm   939 QTKTQLIEKEAVETGKVKFEVYMSYFRA----IGIKIALVFFLVYVASSMLGVFSNLYLARW-SD 998

  Fly   758 NEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISR 822
            :.|.:|.:....:.:....:.   ||.::.:.........|.:.....:.||..||.::...|.|
Worm   999 DAKEIALSGNGSSSETQIRLG---IYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMR 1060

  Fly   823 ASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIV---NPLFLIPAL 884
            :.|.||:..|.|.|||||.||:..||..:|..:...|:..:   .:|.:|||:   .||.:...|
Worm  1061 SPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAV---SSIEIIAIILWATPLAISLLL 1122

  Fly   885 AFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMH 949
            ...||.:.:..||:.||..:||||:::|||:||||..|:.|.|:|||:|.......|.....|.:
Worm  1123 PLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDEN 1187

  Fly   950 SSASYMFISTSRAFAYWMDI---FCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTV 1011
            .:..|..|..:|..|..:::   ..||..|...:.|...|..||..|||:::.|:.:|.|:.|.|
Worm  1188 LATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAV 1252

  Fly  1012 RQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVL 1076
            |.::|||..:::|||:.||.....||....:...|   ||||.|:|.....|:||.|.|  :.||
Worm  1253 RMTSELETNIVAVERINEYTITPTEGNNSQSLAPK---SWPENGEISIKNFSVRYRPGL--DLVL 1312

  Fly  1077 KSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGS-VRIDDKDTNDMGLHDLRSKISIIPQ 1140
            ..::..|.|.||:|||||||||||||..||||:...||. :.||..:..|:.|..|||:::|:||
Worm  1313 HGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQ 1377

  Fly  1141 EPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCL 1205
            :|||||||:|.|||||..:|||::|.||....|...|.|:..||...|:|||.|.|||||||:||
Worm  1378 DPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICL 1442

  Fly  1206 ARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRV 1270
            |||:||..::||:|||.|.||.:||:|:|.|||.:|::|||||:||||:|:|||||:||:|.|.|
Worm  1443 ARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCV 1507

  Fly  1271 VEFGTPYELLTADDTNAFQDLVK 1293
            .||.||.:||:..| ..|..:.|
Worm  1508 AEFDTPKKLLSNPD-GIFYSMAK 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	453/1370 (33%)
		ABC_membrane	94..360	CDD:294371	80/269 (30%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/202 (44%)
		ABC_membrane	736..980	CDD:294371	75/252 (30%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	123/221 (56%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	459/1388 (33%)
		ABC_membrane	309..570	CDD:294371	79/262 (30%)
		ABCC_MRP_domain1	614..815	CDD:213217	88/200 (44%)
		ABC_membrane	976..1248	CDD:279056	83/278 (30%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	123/221 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830