DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and mrp-7

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_507812.3	Gene:	mrp-7 / 180289	WormBaseID:	WBGene00003413	Length:	1525	Species:	Caenorhabditis elegans

Alignment Length:	1400	Identity:	465/1400 - (33%)
Similarity:	726/1400 - (51%)	Gaps:	200/1400 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPRERSNIFSALSFWY--TIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSS---------- 64
            :|..:|:..:.|:.|:  :||.  .|.:..|...|::. |.|.......::|..|
Worm   207 SPELQSSFLNRLTLWWFNSIPW--TGARRDLEIDDIFE-LNERSGTEFLSELWESFWEPKRLKYI 268

  Fly    65 -----WANELETNKKN-----ASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFS 119
                 ||.:..:.::.     .|::..||.:|...|:....:.|..:.:....|..|.:|::..|
Worm   269 HDTSIWAKKDPSEQEKDPVVIPSVVSSLFMMFRWEFLLASTLKFVSDTMQFASPFLLHELLNFIS 333

  Fly   120 -NPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGE 183
             ..:|...|:|.:..  :...|.|:.:::|.|.:.:..:|.||:..:::.:|:|.|.::.:...:
Worm   334 AKNAPFWKGMALSIL--MFSVSELRSLILNGYFYIMFRMGTKIQTSLTAAVYKKTLLISNSARRD 396

  Fly   184 ISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPL--- 245
            .:.|.|:||::.|:.|...........|..|.|.......::..:|.:|:.|:..:::|:|:
Worm   397 RTVGEIVNLMAIDVERFQMITPQIQQFWSCPYQITFALVYLFITLGYSALPGVVIMVIFVPMNII 461

  Fly   246 -QMYLGK-KISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHV 308
             .|.:.| :|..::||     |:|.:::.|::.||:|:|:||||:|.|..:...|.||:..|:..
Worm   462 SSMIVRKWQIEQMKLK-----DERTKMVNEVLNGIKVVKLYAWEVPMEAYIDEIRTKELALIKKS 521

  Fly   309 AYAKCLIWSFNR---FLTPVSIFLSLVGFVLM--GRFLTAEVAFLITAYYNVVRTNMTAYFSVGV 368
            |..:.::.|||.   ||  |::| |...|||.  ...||.::||:..|.:|.:|:.|| ..::.:
Worm   522 AMVRNILDSFNTASPFL--VALF-SFGTFVLSNPSHLLTPQIAFVSLALFNQLRSPMT-MIALLI 582

  Fly   369 TQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDC 433
            .|..:.:||.||:::.|::.|:   ||..|......:                       .|.:.
Worm   583 NQAVQAVVSNKRLKEFLVAEEL---DEKCVDRSVNIE-----------------------RSHNA 621

  Fly   434 VSISELKAKWTTN--SPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVT 496
            |.:..|.|.|...  :.:.||..|:|.....:|:|:||..|||||||:||:|||:....|.|.|.
Worm   622 VRVENLTASWDPEEAAGEKTLQDVDLTAPRNSLIAVVGKVGSGKSSLLQALLGEMGKLRGRIGVN 686

  Fly   497 GSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSG 561
            |.::|..|:||:.:.|:|.||.||:|.||:|||.|:..|||:.|.::||..|:|.:|::|.:|||
Worm   687 GRVAYVPQQPWIQNMTLRDNITFGRPFDRKRYDQVLYACALKADIKILPAGDQTEIGEKGINLSG 751

  Fly   562 GQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQLQFLQQA 624
            |||||:||||:||::..:|||||||||||:.|.|.:||:.:  .|.||:|..|||||.|.:.:.|
Worm   752 GQKARVSLARAVYQNLDVYLLDDPLSAVDAHVGRHIFEKVIGPNGLLREKTRILVTHGLTYTKMA 816

  Fly   625 DQIVIMEMGKVKAVGTYESL-------------HKSGLD---------------FGIVLDDPVND 661
            |:|::|..||::..||:|.|             :|||.|               .|..:.|.:|.
Worm   817 DEILVMLEGKIEESGTFEHLIKRRGLFFDFMEEYKSGSDNSSEAGGSQDDDFEAIGGEIQDYMNP 881

  Fly   662 NEAA-------EDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGRNG------ 713
            .:..       ::..||..:|.|     .|.:|..|..|...........|.:.:.:.|
Worm   882 EDVVLTVTNDLDETIRTPELTTQ-----ISTMSSPEKPPTGTSPAAATESQNKLIKKEGIAQGKV 941

  Fly   714 -LGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDA---- 773
             :..|..|.:|.|..||.:.: .||:....|..|..::||.|        :..|..|:..|
Worm   942 EIATYQLYVKAAGYLLSIAFI-GFFIVYMTLQILRSFWLSAW--------SDEYDPDSPSAHPMA 997

  Fly   774 -----------DFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYF 827
                       .|...|.:...|:.::.:             ..|||..||..:...:.|:.|.|
Worm   998 KGWRLGVYGALGFSETACFFVALLALVFV-------------GQRASKNLHGPLIHNLMRSPMSF 1049

  Fly   828 FNKNPAGSILNRFSKDMGQVDEMLPT----IIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGI 888
            ::..|.|.||||.:||:..:|.|||.    ::|.|:|  :.|  .:|||.|..|||.:..|...:
Worm  1050 YDTTPLGRILNRCAKDIETIDMMLPMNFRYLVMCVLQ--VAF--TLIVIIISTPLFAVVILPLAL 1110

  Fly   889 VIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFG--------AGSILEAEFDGY 945
            :......:|:.||..:||||:..|||:||||..::.|.::|||||        :|.||
Worm  1111 IYLIFLRYYVPTSRQLKRLESVHRSPIYSHFGETIQGAASIRAFGKVDEFRQDSGRIL------- 1168

  Fly   946 QDMHSSASYMFISTSRAFAYWMDIF--CVLFIAMITLSFFIFPP-----SSAADVGLAITQAMGL 1003
             |......|..:.::|..|..::..  |::|.|.:   |.:...     :|...:|::::.|:.:
Worm  1169 -DTFIRCRYSSLVSNRWLAVRLEFVGNCIIFFAAL---FAVLSKEFGWITSPGVIGVSVSYALNI 1229

  Fly  1004 TGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEP 1068
            |..:.:.|||.:|:|..::||||:.||.....|.|..... ::|...||.:|.::|...|.||..
Worm  1230 TEVLNFAVRQVSEIEANIVSVERVNEYTNTPNEAPWRIEG-REPAPGWPSRGVVKFDGYSTRYRE 1293

  Fly  1069 YLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLR 1132
            .|  :.||..:|..:...||:||||||||||||...|||| :....|.:.|||.:.:.:||||||
Worm  1294 GL--DLVLHDISADVAAGEKIGIVGRTGAGKSSFALALFRMIEAAGGRIVIDDVEVSQIGLHDLR 1356

  Fly  1133 SKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSV 1197
            |.|:||||:|||||||:|.|||||..||||::|.|||...||...|.:..||..||:|.|.|.||
Worm  1357 SNITIIPQDPVLFSGTLRFNLDPFFTYSDDQIWRALELAHLKHFAAGLPDGLLYKISEAGENLSV 1421

  Fly  1198 GQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRV 1262
            ||||||.||||:||..|:||:|||||.||..||||||.|||.:|:||||.|:||||:||||.||:
Worm  1422 GQRQLVALARALLRHTRVLVLDEATAAVDVATDALIQETIREEFKECTVFTIAHRLNTIMDYDRI 1486

  Fly  1263 LVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQ 1297
            :|:|.|.::||.|| :.|.||..:||..:|....:
Worm  1487 MVLDKGSILEFDTP-DALMADKNSAFAKMVADAAE 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	459/1382 (33%)
		ABC_membrane	94..360	CDD:294371	73/276 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	98/203 (48%)
		ABC_membrane	736..980	CDD:294371	75/272 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	128/221 (58%)
mrp-7	NP_507812.3	MRP_assoc_pro	14..1518	CDD:188098	465/1396 (33%)
		ABC_membrane	310..575	CDD:294371	73/274 (27%)
		ABCC_MRP_domain1	622..826	CDD:213217	98/203 (48%)
		ABC_membrane	976..1227	CDD:279056	74/286 (26%)
		ABCC_MRP_domain2	1280..1500	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.730