DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and cft-1

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_504463.1	Gene:	cft-1 / 178939	WormBaseID:	WBGene00000477	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	1350	Identity:	342/1350 - (25%)
Similarity:	615/1350 - (45%)	Gaps:	200/1350 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSS-- 64
            :..:||  .||.:.:|:..|.|..........|.:..|:...||         ..|..|.||:
Worm    14 RQIQNE--TENEQAKSSFASKLLELPVSKLLQKCRSSTITVDDL---------PILEEKQCSNRV 67

  Fly    65 -----WANELETNKKNASLLRVLFRVFGRYF-VFLGLVLFCLEVILT--VQPMFLMKLISSFSNP 121
                 |       ||     ||:|.:..::: .|.|...|.:..|..  ...:.|..||.|....
Worm    68 MSGFKW-------KK-----RVIFSILMKFWKSFAGAFAFRMCAIFADYASILLLKYLIDSAEIS 120

  Fly   122 SPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLT-------KT 179
            :...|  .:..|..::....||.:|:..:::.|....:::...::::|.:|.|.||       ::
Worm   121 ATLFN--FFIIAVLILFFMQLKSLLLGVHTYLVGEDSVEMVTVLNNIIVKKALHLTSENTDWNRS 183

  Fly   180 DLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILL--- 241
            .:.::.|.| ...:||.|.       :.|:...|.::..:..:.:::.:|...:..:..:.|
Worm   184 KISKLLTTH-SEAVSNGLA-------YVHHSCSALIELTIALFWIWETLGTRTIIVVLIVALVYA 240

  Fly   242 -FIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSI 305
             |..:..|:.||...::||.   .|:|:.....::..::.|||::||..|.|.:...|.||::..
Worm   241 VFNIIDSYVYKKSLKVQLKC---RDERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVF 302

  Fly   306 RHVAYAKCLIWSFNRFLTPVSI----FLSLVGFVLMG--------RFLTAEVAFLITAYYNVVRT 358
            |     |.|  |.|.|:..:::    .::.|.|.:.|        ||   |.||::.|.:|.:|.
Worm   303 R-----KTL--SINSFMHSLNVTSPFVITFVSFAVYGLQYEISALRF---EDAFVLIAIFNYMRR 357

  Fly   359 NMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTP---- 419
            .:..           .:.|::.|.|.|.|..::                  .:.|:|..:|
Worm   358 PLHV-----------IIPSLEIVDKALHSATII------------------NQFLIVKQSPKINT 393

  Fly   420 MRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILG 484
            ..||:.|   .|..:.|..|.|.::.|..|.||:.|.:.|..|...|.:|....|||||:.:|.|
Worm   394 KTAPQPP---VEPDLDIKILNANFSWNGKDDTLNDVCVHVKKGEKHAFIGFPLCGKSSLLFSITG 455

  Fly   485 ELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDK 549
            ||::..|.:.|:..:|:|...|::||.::::|||||....:.:||.|:..|.|::|...||..:.
Worm   456 ELKMTKGNMWVSKGISFAPASPYIFSQSLKENILFGNDYVKSKYDKVIMACDLKKDIFSLPRCEA 520

  Fly   550 TILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVI 612
            |:|||:|..|:..|||:|||||.:|.||.||.||.....:|.:.:.::|...|  .|:||||.||
Worm   521 TVLGDKGYVLTSTQKAQISLARCLYEDADIYALDKAFGPMDRTTSNKIFTRVLGENGYLRDKTVI 585

  Fly   613 LVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSRTSSITDQ 677
            |.|:.::.::....:.:::.||::..|:|:.:    |:...::.|.:|       :||...|.::
Worm   586 LATNNIELIKTFTMVHVLKNGKIETSGSYDQI----LECSEIMSDLLN-------QSRIDKIIEE 639

  Fly   678 RRSSVKSVLSHAESCP-EDVGEEQKINLQRQQLGR--------NGLGVYVDYFRAGGG-FLSFSV 732
            :.|.        |..| :.|..:.|:..:|::...        ....||..|||:|.. |.:|.:
Worm   640 KYSD--------EKPPRKTVMFDDKVLKKRKKKQSMEDTAPVFENRSVYPFYFRSGSFIFTAFYI 696

  Fly   733 VMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIY---MLITVLSIMVT 794
            |:  .:|.....:|..::||.|:....|.|           :.|....|::   |....:|.:::
Worm   697 VL--LICRFVFQALAFFWLSFWLDPVWKKV-----------ECENCPQYVFIQTMSFFAISAIIS 748

  Fly   795 IKRSFLFFNLA-MRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTII--- 855
            ...|:.||.|. ::.|.:|:..:...|....|.|.:.....|::|..:.|:..||...|...
Worm   749 TMLSYTFFVLTNVQTSRKLYQHITSAIFAVPMIFLSPTNKESLMNMITSDLDIVDTQFPLFFKFS 813

  Fly   856 ----MTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVY 916
                :.::..|.:...|:.|.||....|||  ...|::.|:|.:.:..:||:.::.:......:
Worm   814 FECTLHILMIFAIVCVNVPVFAIFVVAFLI--FLVGLLRYFLPALHKISSLEEQKRDLFLCGSI- 875

  Fly   917 SHFAASLNGLSTIRAFG------AGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFI 975
            ..|.|.:    .:|.||      |.:.:.|:......|...::..:||....|...:.|....||
Worm   876 EDFEARI----MVRTFGKTRQTLAKTSVNADILTRCRMARYSTLRWISLRTEFISNLMICMCFFI 936

  Fly   976 AMITLSF-FIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPL 1039
            |.|.|.. :|    ..|...|::...:.::..|...:|.:..||:....|:|:....|.    |.
Worm   937 ASICLKVDYI----GNAQFALSVASILCISELVSTFIRTTCILESLTPHVQRISNVREY----PK 993

  Fly  1040 EATADK-KPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLI 1103
            |...|| ...:|||:.||||...|::....|   ..|:|.:|.||:.:||:||:|:.|:|||.|.
Worm   994 EPMIDKCTIRDSWPDDGKIEIKNLNVFANKY---RHVIKDVSLVIEEREKLGIIGKVGSGKSQLA 1055

  Fly  1104 NALFRLSYND--GSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWC 1166
            ..|..:|..|  ..:.:||.|..:|.:..|||:|::|||:..:||.|:|.|:||..:::|..:|.
Worm  1056 KTLVMMSSADKESHIVVDDLDIFEMSVKTLRSRITVIPQKAKIFSDTLRSNIDPCCQFADSDIWL 1120

  Fly  1167 ALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDA 1231
            |:|..:|::.|.|:..||...::.  ...|..|:..|.:.||:|:..:|.|:|::|..:.....:
Worm  1121 AIEACQLREYVKSLPDGLHQMVSP--EKMSNEQKCQVNVCRALLKGGQIFVIDQSTKMMKEPIKS 1183

  Fly  1232 LIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLT 1281
            |:...|||..::.|.:.:......:...|||:|::.|.::...||..|::
Worm  1184 LVNEAIRNSLKQSTTIWIGEDFSDVEHCDRVVVIENGVILTTDTPQNLIS 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	339/1338 (25%)
		ABC_membrane	94..360	CDD:294371	62/290 (21%)
		ABCC_MRP_domain1	434..634	CDD:213217	74/201 (37%)
		ABC_membrane	736..980	CDD:294371	55/260 (21%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	71/222 (32%)
cft-1	NP_504463.1	MdlB	76..631	CDD:224055	159/620 (26%)
		ABC_membrane	93..359	CDD:294371	61/288 (21%)
		P-loop_NTPase	407..607	CDD:304359	74/199 (37%)
		ABC_membrane	696..938	CDD:294371	54/261 (21%)
		P-loop_NTPase	1010..1228	CDD:304359	71/222 (32%)
		EcfA2	1012..1234	CDD:224047	72/226 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850