DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Abcc3

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_542148.2	Gene:	Abcc3 / 140668	RGDID:	71101	Length:	1523	Species:	Rattus norvegicus

Alignment Length:	1394	Identity:	485/1394 - (34%)
Similarity:	749/1394 - (53%)	Gaps:	166/1394 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FKNEDLPEN--PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW- 65
            |..|:|..|  |...:..||.||||:.....|.|.:..|...||:...:|..:..:..:|..:|
  Rat   197 FSPENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQ 261

  Fly    66 ------------------ANELET------NKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTV 106
                              |.|.|.      ..|..|.||.|.|.|....:.........:::..:
  Rat   262 KQQTQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLLMGACFKLIQDLLSFI 326

  Fly   107 QPMFLMKLISSFSNP-SPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIY 170
            .|..|..||...|:| :||..|  :..||.:.:.|.::.::::.:...:..:.|:||..:..:||
  Rat   327 NPQLLSILIRFISDPTAPTWWG--FLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIY 389

  Fly   171 RKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFG 235
            ||.|.:|.:...|.:.|.::||:|.|..|......|.:.||.||||.::..|.::|.:|.:|:.|
  Rat   390 RKALTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAG 454

  Fly   236 MTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHK 300
            :..|:|.|||...:..|:...:::.....|.|:::|:||:.||:|:|:||||..|.:.|...|..
  Rat   455 VAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQS 519

  Fly   301 EINSIRHVAYAKCL---IWSFNRFLTPVSIFLSLVG-FVLMGR--FLTAEVAFLITAYYNVVR-- 357
            |:..:|..||.:.:   ||    ..||..:.|..:| :|.:.:  .|.||.||:..:.:|:::
  Rat   520 ELQLLRKGAYLQAISTFIW----VCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIP 580

  Fly   358 TNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRA 422
            .|:......|:|||:   ||:||:|..|              |..|.|.|....|   |.:|.||
  Rat   581 LNLLPQLISGMTQTS---VSLKRIQDFL--------------NQDELDPQCVERK---TISPGRA 625

  Fly   423 PEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELR 487
                       ::|......|:.:.|. ||..:|:|:..|||||:||..|.|||||:.|:|||:.
  Rat   626 -----------ITIHNGTFSWSKDLPP-TLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEME 678

  Fly   488 VESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTIL 552
            ...|.:.|.||::|..|:.|:.:.|:::|:||||||:.:||...:..|||..|.::||..|:|.:
  Rat   679 KLEGAVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEI 743

  Fly   553 GDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVT 615
            |::|.:|||||:.|:||||:||.||:|:|||||||||||.||:.:|::.:  .|.|..|..:|||
  Rat   744 GEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVT 808

  Fly   616 HQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFG--------------------------IV 654
            |.:.||.|.|.|:::..|::..:|.|..|.:....|.                          ::
  Rat   809 HGISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVLL 873

  Fly   655 LDDPVN------DNEAA--EDRSR----TSSITDQRRSSVKSVLS-HAESCPEDVGEEQKIN--- 703
            |:|.::      |.|.|  |.|.:    .||::.:.....:.||. :..|..::|...|...
  Rat   874 LEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETGA 938

  Fly   704 LQRQQLGRNG---LGVYVDYFRAGGGFLSFSVVMTFFVC----SQGLASLG-DYFLSPWVSRNEK 760
            |.::::...|   |.||.||.::.|      :..|.|:|    .|...::| :.:||.|.:..|:
  Rat   939 LIKEEIAETGNVKLSVYWDYAKSVG------LCTTLFICLLYAGQNAVAIGANVWLSAWTNDVEE 997

  Fly   761 MVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASM 825
            ....|.|:....         :|..:.:|..::.:..:|.....|::|:..||.::.....||..
  Rat   998 HGQQNNTSVRLG---------VYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQ 1053

  Fly   826 YFFNKNPAGSILNRFSKDMGQVDEML-PTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIV 889
            .||:..|:|.||||||||:..:||:| |||:| :...|......|:||....|||.:..|...:.
  Rat  1054 SFFDTTPSGRILNRFSKDIYVIDEVLAPTILM-LFNSFYTSISTIVVIVASTPLFCVVVLPLAVF 1117

  Fly   890 IYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASY 954
            ..:::.||:.||..:||||:.:|||::|||:.::.|.|.|||:|.....:...|...|.:...:|
  Rat  1118 YGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTY 1182

  Fly   955 MFISTSRAFAYWMDIF------C-VLFIAMITLSFFIFPPSSAAD--VGLAITQAMGLTGTVQWT 1010
            .:|:::|    |:.:.      | |||.|:    |.:...:|...  |||:::.|:.:|.::.|.
  Rat  1183 PYIASNR----WLGVHVEFVGNCVVLFSAL----FAVIGRNSLNPGLVGLSVSYALQVTLSLNWM 1239

  Fly  1011 VRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESV 1075
            :|..::||:.:|:|||:.||.:.|.|.|....:::.| |.||..|.:||...|:||.|.|  |.|
  Rat  1240 IRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAP-EGWPRSGVVEFRNYSVRYRPGL--ELV 1301

  Fly  1076 LKSLSFVIKPKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIP 1139
            ||:|:..::..|||||||||||||||:...||| |...:|.:.||..:...:|||||||:::|||
  Rat  1302 LKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIP 1366

  Fly  1140 QEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVC 1204
            |:|:|||||:|.|||||..|||:.:|..||...|...|:|..|||:.:.:|||.|.|||||||||
  Rat  1367 QDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVC 1431

  Fly  1205 LARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGR 1269
            ||||:||.:|:||:|||||.:|.:||.|||.|||.:|.:|||||:||||:||||.:||||:|.|.
  Rat  1432 LARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGV 1496

  Fly  1270 VVEFGTPYELLTADDTNAFQDLVKQTGQA 1298
            |.||.:|..|:.|.  ..|..:.|..|.|
  Rat  1497 VAEFDSPVNLIAAG--GIFYGMAKDAGLA 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	477/1367 (35%)
		ABC_membrane	94..360	CDD:294371	79/274 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	92/201 (46%)
		ABC_membrane	736..980	CDD:294371	77/256 (30%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	129/221 (58%)
Abcc3	NP_542148.2	MRP_assoc_pro	7..1522	CDD:188098	483/1391 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660