DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and Cftr

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_066388.1	Gene:	Cftr / 12638	MGIID:	88388	Length:	1476	Species:	Mus musculus

Alignment Length:	1491	Identity:	420/1491 - (28%)
Similarity:	724/1491 - (48%)	Gaps:	217/1491 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNK 73
            :.::|.|:::..|.|.|.:|.|...||.:..|...|:|:|.....|:.|..||...|..| :.:|
Mouse     1 MQKSPLEKASFISKLFFSWTTPILRKGYRHHLELSDIYQAPSADSADHLSEKLEREWDRE-QASK 64

  Fly    74 KNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVIL 138
            ||..|:..|.|.|...|:|.|::|:..||...|||:.|.::|:|:...:.....:|.....|:.|
Mouse    65 KNPQLIHALRRCFFWRFLFYGILLYLGEVTKAVQPVLLGRIIASYDPENKVERSIAIYLGIGLCL 129

  Fly   139 GSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTF 203
            ...::.:|::|..|.:..:|:::|..:.|:||:|.|:|:...|.:||.|.:::|:||:|.:.|..
Mouse   130 LFIVRTLLLHPAIFGLHRIGMQMRTAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEG 194

  Fly   204 IQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRM 268
            :...|::|:||||..::..|::..:..:|..|:..:::.:..|..|||.:...|.:.|.:.::|:
Mouse   195 LALAHFIWIAPLQVTLLMGLLWDLLQFSAFCGLGLLIILVIFQAILGKMMVKYRDQRAAKINERL 259

  Fly   269 RIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWS---FNRFLTPVSIFLS 330
            .|.:|||..|..:|.|.||...|||:.:.|..|:...|..||.:....|   |:.|..   :|||
Mouse   260 VITSEIIDNIYSVKAYCWESAMEKMIENLREVELKMTRKAAYMRFFTSSAFFFSGFFV---VFLS 321

  Fly   331 LVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDE 395
            ::.:.::...:..:: |...::..|:|.::|..|...|....::...|:::|..|...|....:.
Mouse   322 VLPYTVINGIVLRKI-FTTISFCIVLRMSVTRQFPTAVQIWYDSFGMIRKIQDFLQKQEYKVLEY 385

  Fly   396 NVVSNGA---------EEDLQEAREKLLVTPTPMRAPEKPPHNS-EDCVSISELKAKWTTNSPDY 450
            |:::.|.         ||...|..||:      .::.....|:| |:.||.|.|   ....:|
Mouse   386 NLMTTGIIMENVTAFWEEGFGELLEKV------QQSNGDRKHSSDENNVSFSHL---CLVGNP-- 439

  Fly   451 TLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQ 515
            .|..:||.:..|.::||.|.|||||:||:..|||||....|.|:.:|.:|:.||..|:..||:::
Mouse   440 VLKNINLNIEKGEMLAITGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKE 504

  Fly   516 NILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIY 580
            ||:||...|..||..||:.|.|::|......:|.|:||:.|.:|||||:|||||||:||:||.:|
Mouse   505 NIIFGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARISLARAVYKDADLY 569

  Fly   581 LLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLH 645
            |||.|...:|.....::||.|:...:.:|..||||.:::.|::||:|:|:..|.....||:..|.
Mouse   570 LLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSKMEHLRKADKILILHQGSSYFYGTFSELQ 634

  Fly   646 KSGLDF------------------GIVLDD-----PVNDNEAAEDRSR-----TSSITDQRRSSV 682
            ....||                  ..:|.:     .|:|:.|...:.:     |..:.::|::|:
Mouse   635 SLRPDFSSKLMGYDTFDQFTEERRSSILTETLRRFSVDDSSAPWSKPKQSFRQTGEVGEKRKNSI 699

  Fly   683 K---------SVLSHAESC----PEDVGEEQ---------------------------------- 700
            .         |::.....|    .:|:.|::
Mouse   700 LNSFSSVRKISIVQKTPLCIDGESDDLQEKRLSLVPDSEQGEAALPRSNMIATGPTFPGRRRQSV 764

  Fly   701 -----------KINLQR-----------QQLGRNGLGV--------------------------- 716
                       ..||||           .|:..|.:.|
Mouse   765 LDLMTFTPNSGSSNLQRTRTSIRKISLVPQISLNEVDVYSRRLSQDSTLNITEEINEEDLKECFL 829

  Fly   717 --------------YVDYFRAGGGFLSFSV--VMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHN 765
                          |:.||....|.|...:  |:.|.|  :..|||  :.|  |:.:|..:.:.|
Mouse   830 DDVIKIPPVTTWNTYLRYFTLHKGLLLVLIWCVLVFLV--EVAASL--FVL--WLLKNNPVNSGN 888

  Fly   766 YTTDAKDADFEM--------HAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISR 822
            ..|...::.:.:        :..|||:.:....:.:::.|.....:..:.||..||..|...|..
Mouse   889 NGTKISNSSYVVIITSTSFYYIFYIYVGVADTLLALSLFRGLPLVHTLITASKILHRKMLHSILH 953

  Fly   823 ASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP-LFL--IPAL 884
            |.|...:|..||.||||||||:..:|:.||..|...||...:..|.|||::.:.| :||  :|.|
Mouse   954 APMSTISKLKAGGILNRFSKDIAILDDFLPLTIFDFIQLVFIVIGAIIVVSALQPYIFLATVPGL 1018

  Fly   885 AFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMH 949
               :|...||:::|.|:..:|:||:..|||:::|...||.||.|:|||...:..|..|....::|
Mouse  1019 ---VVFILLRAYFLHTAQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFRRQTYFETLFHKALNLH 1080

  Fly   950 SSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQS 1014
            ::..:|:::|.|.|...:|:..|||..::|....:.........|:.:|.||.:..|:||.|..|
Mouse  1081 TANWFMYLATLRWFQMRIDMIFVLFFIVVTFISILTTGEGEGTAGIILTLAMNIMSTLQWAVNSS 1145

  Fly  1015 AELENTMISVERMIEYEEIEPEG----------PLEATAD----KKPH----ESWPEQGKIEFVE 1061
            .:.::.|.||.|:.::.:|:.|.          |.|.::|    |..|    :.||..|::...:
Mouse  1146 IDTDSLMRSVSRVFKFIDIQTEESMYTQIIKELPREGSSDVLVIKNEHVKKSDIWPSGGEMVVKD 1210

  Fly  1062 LSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDM 1126
            |:::|..  ...:||:::||.|.|.::||::||||:|||:|::|..|:....|.:.||....|.:
Mouse  1211 LTVKYMD--DGNAVLENISFSISPGQRVGLLGRTGSGKSTLLSAFLRMLNIKGDIEIDGVSWNSV 1273

  Fly  1127 GLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEG 1191
            .|.:.|....:|.|:..:||||.|.||||..::.|:.:|...:||.||.|:......|...:.:|
Mouse  1274 TLQEWRKAFGVITQKVFIFSGTFRQNLDPNGKWKDEEIWKVADEVGLKSVIEQFPGQLNFTLVDG 1338

  Fly  1192 GSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTI 1256
            |...|.|.:||:||||::|...:|:::||.:|::||.|..:|:..::..|..|||:...||:..:
Mouse  1339 GYVLSHGHKQLMCLARSVLSKAKIILLDEPSAHLDPITYQVIRRVLKQAFAGCTVILCEHRIEAM 1403

  Fly  1257 MDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKP 1317
            :|..|.||::...|.::.:...||:  :.:.||..:..:.:      ::..|.......||
Mouse  1404 LDCQRFLVIEESNVWQYDSLQALLS--EKSIFQQAISSSEK------MRFFQGRHSSKHKP 1456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	414/1450 (29%)
		ABC_membrane	94..360	CDD:294371	75/268 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/199 (43%)
		ABC_membrane	736..980	CDD:294371	79/254 (31%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	76/220 (35%)
Cftr	NP_066388.1	CFTR_protein	1..1464	CDD:273530	420/1491 (28%)
		ABC_membrane	85..303	CDD:294371	66/217 (30%)
		ABCC_CFTR1	389..670	CDD:213258	101/291 (35%)
		CFTR_R	639..844	CDD:291094	20/204 (10%)
		Disordered R region. /evidence=ECO:0000250\|UniProtKB:P13569	654..826		18/171 (11%)
		ABC_membrane	861..1142	CDD:279056	88/289 (30%)
		ABCC_CFTR2	1204..1464	CDD:213256	83/263 (32%)
		Interaction with GORASP2. /evidence=ECO:0000250\|UniProtKB:P13569	1382..1476		18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1446..1476		3/11 (27%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:P13569	1474..1476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850