DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_005836.2	Gene:	ABCC4 / 10257	HGNCID:	55	Length:	1325	Species:	Homo sapiens

Alignment Length:	1348	Identity:	568/1348 - (42%)
Similarity:	826/1348 - (61%)	Gaps:	88/1348 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANEL-- 69
            :::..||.:.:|:.|.:.||:..|.|..|.|..|...|:|..|.|.|::.||.:|...|..|:
Human     6 QEVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70

  Fly    70 -ETNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSN---GVAY 130
             |.:.:..||.|.:.:.:.:.::.||:.....|....:||:||.|:|:.|.|..|..:   ..||
Human    71 AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAY 135

  Fly   131 AYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISN 195
            |||..:...:.:..||.:.|.:.|...|:::||.:..|||||.|||:...:|:.:||.|:||:||
Human   136 AYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSN 200

  Fly   196 DLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKT 260
            |:.:.|....|.|:||..||||:.||.|::.||||:.:.||..:::.:|||...||..|.||.||
Human   201 DVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKT 265

  Fly   261 AIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCL----IWSFNRF 321
            |..:|.|:|.|.|:|.||::|||||||..|..::.:.|.|||:.|..   :.||    :.||..
Human   266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILR---SSCLRGMNLASFFS- 326

  Fly   322 LTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLLL 386
            .:.:.:|::...:||:|..:||...|:....|..||..:|.:|...:.:.:|.:|||:|:|..||
Human   327 ASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLL 391

  Fly   387 SGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYT 451
            ..|:..::..:.|:|                             :..|.:.:..|.|...|...|
Human   392 LDEISQRNRQLPSDG-----------------------------KKMVHVQDFTAFWDKASETPT 427

  Fly   452 LSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQN 516
            |.|::..|..|.|:|:||..|:|||||:.|:||||....|.:.|.|.::|.||:||:||||:|.|
Human   428 LQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSN 492

  Fly   517 ILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYL 581
            ||||:..::.||:.|::.|||::|.:||...|.|::||||.:||||||||::|||:||:||.|||
Human   493 ILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYL 557

  Fly   582 LDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHK 646
            |||||||||:.|:|.|||.|:...|.:||.||||||||:|:.|.||:|::.||:...|||....|
Human   558 LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLK 622

  Fly   647 SGLDFGIVLDDPVNDNEAAED---------RSRT---SSITDQR--RSSVKS---VLSHAESCPE 694
            ||:|||.:|.   .|||.:|.         |:||   ||:..|:  |.|:|.   .....|:.|.
Human   623 SGIDFGSLLK---KDNEESEQPPVPGTPTLRNRTFSESSVWSQQSSRPSLKDGALESQDTENVPV 684

  Fly   695 DVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNE 759
            .:.||.:..      |:.|...|.:|||||..::.|..::.....:|....|.|::||.|.::..
Human   685 TLSEENRSE------GKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQS 743

  Fly   760 KMVAHNYT-------TDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMF 817
            .:   |.|       |:..|.::.:.   ||..:||.:::..|.||.|.|.:.:.:|..|||.||
Human   744 ML---NVTVNGGGNVTEKLDLNWYLG---IYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMF 802

  Fly   818 RGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIP 882
            ..|.:|.:.||::||.|.||||||||:|.:|::||...:..||..|...|.:.|...|.|...||
Human   803 ESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIP 867

  Fly   883 ALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQD 947
            .:..||:..:||.::|:||.||||||::|||||:||.::||.||.||||:.|....:..||.:||
Human   868 LVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQD 932

  Fly   948 MHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPS-SAADVGLAITQAMGLTGTVQWTV 1011
            :||.|.::|::|||.||..:|..|.:|:.::.....|...: .|..||||::.|:.|.|..||.|
Human   933 LHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCV 997

  Fly  1012 RQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVL 1076
            |||||:||.||||||:|||.::|.|.|.|  ..|:|..:||.:|.|.|..::..|.|  ....||
Human   998 RQSAEVENMMISVERVIEYTDLEKEAPWE--YQKRPPPAWPHEGVIIFDNVNFMYSP--GGPLVL 1058

  Fly  1077 KSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQE 1141
            |.|:.:||.:|||||||||||||||||:||||||..:|.:.||...|.::||||||.|:||||||
Human  1059 KHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQE 1123

  Fly  1142 PVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLA 1206
            ||||:||:|.|||||:|::|:.||.||:||:||:.:..:...::|::.|.|||||||||||||||
Human  1124 PVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLA 1188

  Fly  1207 RAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVV 1271
            |||||.|:||::|||||||||:||.|||..||.||..|||||:||||:||:|||:::|:|:||:.
Human  1189 RAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLK 1253

  Fly  1272 EFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQREFEKSEKPSL 1319
            |:..||.|| .:..:.|..:|:|.|:|....|.:.:::.:.|...|.:
Human  1254 EYDEPYVLL-QNKESLFYKMVQQLGKAEAAALTETAKQVYFKRNYPHI 1300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	559/1303 (43%)
		ABC_membrane	94..360	CDD:294371	104/272 (38%)
		ABCC_MRP_domain1	434..634	CDD:213217	106/199 (53%)
		ABC_membrane	736..980	CDD:294371	98/250 (39%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	135/220 (61%)
ABCC4	NP_005836.2	CFTR_protein	11..1269	CDD:273530	560/1310 (43%)
		ABC_membrane	96..365	CDD:294371	104/272 (38%)
		ABCC_MRP_domain1	410..610	CDD:213217	106/199 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..688		8/30 (27%)
		ABC_membrane	718..991	CDD:279056	106/278 (38%)
		ABCC_MRP_domain2	1039..1258	CDD:213211	135/220 (61%)
		PDZ-binding	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151546
Domainoid	1	1.000	226	1.000	Domainoid score	I2519
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I233
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm40263
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910