DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc9

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_031754288.1	Gene:	abcc9 / 101733439	XenbaseID:	XB-GENE-6074535	Length:	1577	Species:	Xenopus tropicalis

Alignment Length:	1402	Identity:	426/1402 - (30%)
Similarity:	714/1402 - (50%)	Gaps:	189/1402 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNK------KNA 76
            |:.|..::|:..|..|...|..:..|.:.:.....||  |.|.|....|.|.:..|      |:.
Frog   221 NLLSKATYWWMNPLIISAHKRPIDLKTIGKLPIAMRA--LTNYLSLKTAYEEQKKKLVDRPHKDP 283

  Fly    77 SLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMF---LMKLISSFSNPSPT-------------- 124
            |:.:.::|.|||..:......:..:::....|:.   :::|:.| .|..||
Frog   284 SIWKAIYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQLLDS-RNKGPTDQDFPKTNFSSVYF 347

  Fly   125 --SNG-VAYAYAGGVILGSALKVILMNPY---SFAVT-HLGLKIRVGVSSMIYRKCLRLTKTD-- 180
              |.| :...|...|:|..||  ||...:   |:.|| ..|:.:|..:.||||.|.|||:.::
Frog   348 LSSKGLIENYYVLAVLLFLAL--ILQRTFLQASYYVTIETGINLRGALLSMIYNKILRLSTSNMS 410

  Fly   181 LGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPL 245
            :||::.|.|.||::.:..::..|:.....||..|:|.:|...|:::.:|::|:.|...|:|..|:
Frog   411 MGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPIQIIMGVILLHKLVGVSALVGAAVIVLLAPM 475

  Fly   246 QMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAY 310
            |.::..|::.::..|...|.:|::...||:.||:::|:||||..|...|...|.||:.|::..|
Frog   476 QYFIATKLAEVQKNTLDYSTERLKKTNEILKGIKLLKLYAWENIFCNSVEETRIKELKSLKTFA- 539

  Fly   311 AKCLIWSFNRFLTPVSIFLS--------LVGFV----LMGRFLTAEVAFLITAYYNVVRTNMTAY 363
                      ..|.:|||::        |..||    :....||...||...:.::::.|.:...
Frog   540 ----------LHTSLSIFMNAAIPIAAVLATFVTHAYVSSSHLTPANAFASLSLFHILVTPLFLL 594

  Fly   364 FSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDL--QEARE------KLLVTPTPM 420
            .:| |....:.|||::::.:...|.|:   .|:...|| |..|  :..|:      :......|:
Frog   595 STV-VRFAVKALVSVQKLNEFFTSDEI---REDGFRNG-ETTLPFESCRKHPGIHSRAFNRKQPL 654

  Fly   421 R--------APEKPPHNS--EDCVSISELKA-----KWTTNSPDYTLSGVNLQVHAGALVAIVGH 470
            |        ||::....|  ||    :.||.     .|.|...  ||:.:::|:..|.|..|||.
Frog   655 RYQMDKYDQAPKRQVRTSDTED----AALKVCGGFFSWGTGLA--TLANIDIQIPTGELTMIVGQ 713

  Fly   471 TGSGKSSLIQAILGELRVESGEI--------------EVTG--------------SMSYASQEPW 507
            .|.|||||:.|||||::...|.:              ...|              |::||.|:||
Frog   714 VGCGKSSLLLAILGEMQTLEGRVVWNKFGSQRRAPGSSANGWDSACGSERSKNRHSVAYAGQKPW 778

  Fly   508 LFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARS 572
            |.:.|:.:||.||.|.:::||..|...|:|:.|.:|||..|:|.:|:||.:|||||:.||.:||:
Frog   779 LLNATLEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARA 843

  Fly   573 VYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKV 635
            :|::.:|..||||.||:|..::..|.:|.:...||:  :.|:||||:||:|..||.|:.|:.|.|
Frog   844 LYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLREDKRTVVLVTHKLQYLPHADWIIAMKDGSV 908

  Fly   636 KAVGTYESLHKSGLDFGIVLDDPVNDNE--------------AAEDRSRTSSITDQRRSSVKSVL 686
            ...||.:.:..             ||||              ..|..|....:|.:|::..:::.
Frog   909 LREGTLKDIQN-------------NDNELYEHWKTLMNRQDQELEKDSDADQVTMERKTLRRAMY 960

  Fly   687 SHAESCPEDVGEEQKINLQRQQLGRNGLGVYVD--------YFRAGGGFLSFSVVMTFFVCSQGL 743
            |.......:..||::......:.....:.:...        |..:||..|.|.::.:..:....:
Frog   961 SREAKVQAEEEEEEEEEEDEDETMSTAMRLRTKFPWRTCWRYLTSGGYLLLFLMIFSKLLKHSVI 1025

  Fly   744 ASLGDYFLSPWVSRNEKM---VAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLA 805
            .:: ||:|:.|.|....:   .:.|.|:.::.:..:.:....:.:::...|::.:..|.....:.
Frog  1026 VAI-DYWLASWTSETSNISYAQSDNVTSASELSSIQSYYVTGFSVLSATGIVLCLIASLTVEWMG 1089

  Fly   806 MRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNII 870
            :.|:..||:::.:.|..|.:.||:..|.|.||||||.|...:|:.:|..:.::.:..||....|.
Frog  1090 LNAAKNLHHNLLKKIILAPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIG 1154

  Fly   871 VIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAG 935
            ||:...|:.::..|..|:..|:::.::...|.|::.|:.||:.|:..||:.:..||:|||||..
Frog  1155 VISYATPISMVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRH- 1218

  Fly   936 SILEAEFDGYQDM-----HSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAAD--- 992
               ||.|.  |.|     .::.:|:|:|.:..   |:::......|.|.|:..:|..:...|
Frog  1219 ---EARFK--QRMLELTDTNNLAYLFLSAANR---WLEVRTDYLGACIVLTAAVFSITYGLDSGI 1275

  Fly   993 VGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEP---EGPLEATADKKPHESWPEQ 1054
            |||.:|.|:.:|..:.|.||..|:||..:.:|:::..:..||.   ||.:|   .::..|.||:.
Frog  1276 VGLGLTYALTVTNYLNWVVRNLADLEVQIGAVKKVNSFLNIESECYEGSME---QQQVPEDWPQS 1337

  Fly  1055 GKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRI 1118
            |:|...:|.:|||.  ..:.|||.|...|||.:||||.||||:|||||..|.||: ...||.:.|
Frog  1338 GEIRISDLCVRYEN--NHKPVLKHLKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVI 1400

  Fly  1119 DDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATG 1183
            |..|.:.:.|:.|||::|||.|:|:||||::|.||||..:.||:|||..|:..:||::|.::..|
Frog  1401 DGIDISKLPLNTLRSRLSIILQDPILFSGSIRFNLDPECKCSDERLWEGLDIAQLKNLVKALPGG 1465

  Fly  1184 LETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLT 1248
            |:..:||||.|||||||||.|||||.:|::.||:||||||::|..|:.::|..:...|.:.||:|
Frog  1466 LDAMVTEGGENFSVGQRQLFCLARAFVRNSSILIMDEATASIDMATENILQKVVMTAFADRTVVT 1530

  Fly  1249 VAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDT 1285
            :|||:|||:..|..:||..|.::|..||..||..:|:
Frog  1531 IAHRVHTILTGDVAIVMRRGNILEHDTPGNLLAQEDS 1567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	424/1396 (30%)
		ABC_membrane	94..360	CDD:294371	80/303 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	86/234 (37%)
		ABC_membrane	736..980	CDD:294371	62/251 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	108/221 (49%)
abcc9	XP_031754288.1	MRP_assoc_pro	222..1574	CDD:188098	425/1401 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010