DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and ABCC9

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001364202.1	Gene:	ABCC9 / 10060	HGNCID:	60	Length:	1549	Species:	Homo sapiens

Alignment Length:	1372	Identity:	425/1372 - (30%)
Similarity:	721/1372 - (52%)	Gaps:	142/1372 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETNKKNA------ 76
            |:.|..::|:.....|...|..:..|.:.:.....||  :.|.:|...|.| |..||.|
Human   221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRA--VTNYVCLKDAYE-EQKKKVADHPNRT 282

  Fly    77 -SLLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMF---LMKLISSFSNPSPTSNGVA-------- 129
             |:...::|.|||..:......:..:::....|:.   :::.::...|.:..:.|::
Human   283 PSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEF 347

  Fly   130 --YAYAGGVILGSALKVILMNPY---SFAVT-HLGLKIRVGVSSMIYRKCLRLTKTDL--GEIST 186
              .||...|:|..||  ||...:   |:.|| ..|:.:|..:.:|||.|.|||:.::|  ||::.
Human   348 LENAYVLAVLLFLAL--ILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTL 410

  Fly   187 GHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGK 251
            |.|.||::.:..::..|:.....||..|:|.:|...|:|..:|.:|:.|...|:|..|:|.::..
Human   411 GQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIAT 475

  Fly   252 KISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIW 316
            |::..:..|...|.:|::...||:.||:::|:||||..|.|.|...|.||::|::..|
Human   476 KLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFA------- 533

  Fly   317 SFNRFLTPVSIFLS--------LVGFV----LMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVT 369
                ..|.:|||::        |..||    ..|..|....||...:.::::.|.:....:| |.
Human   534 ----LYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTV-VR 593

  Fly   370 QTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKP-------- 426
            ...:.::|::::.:.|||.|:  .|::..:..:....:..::...|.|..:.. ::|
Human   594 FAVKAIISVQKLNEFLLSDEI--GDDSWRTGESSLPFESCKKHTGVQPKTINR-KQPGRYHLDSY 655

  Fly   427 --------PHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAIL 483
                    |..:|| ::|......::..|...|||.:::::..|.|..|||..|.|||||:.|||
Human   656 EQSTRRLRPAETED-IAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAIL 719

  Fly   484 GELRVESGEI------------EVTG-----SMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLV 531
            ||::...|::            |.|.     |::||:|:|||.:.||.:||.||.|.:::||..|
Human   720 GEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAV 784

  Fly   532 VRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARR 596
            ...|:|:.|.:|||..|:|.:|:||.:|||||:.||.:||::|::.:|..||||.||:|..::..
Human   785 TDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDH 849

  Fly   597 LFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPV 659
            |.:|.:...|:|  :.::||||:||:|..||.|:.|:.|.|...||.:.:....::........:
Human   850 LMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLM 914

  Fly   660 N--DNEAAEDRSRTSSITDQRRSSVKSVLS-HAESCPEDVGEEQKINLQRQQLGRNGLGVYV--- 718
            |  |.|..:| ......|.:|::..:::.| .|::..||..||:    :.::...:.:...:
Human   915 NRQDQELEKD-MEADQTTLERKTLRRAMYSREAKAQMEDEDEEE----EEEEDEDDNMSTVMRLR 974

  Fly   719 ---------DYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDAD 774
                     .|..:||.||...::.:..:....:.:: ||:|:.|.|.      ::.....| ||
Human   975 TKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAI-DYWLATWTSE------YSINNTGK-AD 1031

  Fly   775 FEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNR 839
            ...:.|. :.::....|.:.:..|.....:.:.|:..||:::...|....:.||:..|.|.||||
Human  1032 QTYYVAG-FSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNR 1095

  Fly   840 FSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDV 904
            ||.|...:|:.:|..:.::.:..||....|.:|:...|:||:..|..|:..|:::.::...|.|:
Human  1096 FSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDL 1160

  Fly   905 KRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI 969
            :.|:.||:.|:..||:.:..||:|||||...:..:.......|.::.| |:|:|.:..   |:::
Human  1161 QELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA-YLFLSAANR---WLEV 1221

  Fly   970 ------FCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMI 1028
                  .|::..|.|.   .|...|::..|||.:..|:.:|..:.|.||..|:||..|.:|:::.
Human  1222 RTDYLGACIVLTASIA---SISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVN 1283

  Fly  1029 EYEEIEPEGPLEATAD-KKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIV 1092
            .:..:|.|. .|.|.| .:..|.||::|:|:..:|.:|||..||  .|||.:...|||.:||||.
Human  1284 SFLTMESEN-YEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK--PVLKHVKAYIKPGQKVGIC 1345

  Fly  1093 GRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPF 1156
            ||||:|||||..|.||: ...||.:.||..|.:.:.||.|||::|||.|:|:||||::|.||||.
Human  1346 GRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPE 1410

  Fly  1157 DEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEA 1221
            .:.:|||||.|||..:||::|.|:..||:..:||||.|||||||||.|||||.:|.:.||:||||
Human  1411 CKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEA 1475

  Fly  1222 TANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTN 1286
            ||::|..|:.::|..:...|.:.||:|:|||:|||:.:|.|:||..|.::|:.|| |.|.|.:..
Human  1476 TASIDMATENILQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTP-ESLLAQENG 1539

  Fly  1287 AFQDLVK 1293
            .|...|:
Human  1540 VFASFVR 1546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	421/1358 (31%)
		ABC_membrane	94..360	CDD:294371	78/296 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	85/218 (39%)
		ABC_membrane	736..980	CDD:294371	62/249 (25%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	114/221 (52%)
ABCC9	NP_001364202.1	MRP_assoc_pro	222..1546	CDD:188098	423/1369 (31%)
ABCC9	NP_001364202.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..967		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650