Protein Alignment CG31792 and ABCC5

DIOPT Version :10

• Sequence 1: NP_724148.2
• Gene: CG31792 / 35163
• FlyBaseID: FBgn0051792
• Length: 1323
• Species: Drosophila melanogaster
• Sequence 2: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Alignment Length: 1374
• Identity: 474/1374 - (34%)
• Similarity: 735/1374 - (53%)
• Gaps: 144/1374 - (10%)

  Fly    11 ENPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESLG-NKLCSSWANEL-ETN 72
            ::|.:.:.:||.::| |.:....:..:|..|..:|:: :|.:|.:..:. .:|...|..|| |..
Human    98 QHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEELNEVG 161

  Fly    73 KKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTV---QPMFLMKLISSFSNPSPTSNGVAYAYAG 134
            ...|||.||:: :|.|..:.|.:|  ||.:....   .|.|::|.:..::  ..|.:.:.|:..
Human   162 PDAASLRRVVW-IFCRTRLILSIV--CLMITQLAGFSGPAFMVKHLLEYT--QATESNLQYSLL- 220

  Fly   135 GVILGSALKVILMNPYSFAVT-----HLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLIS 194
             ::||..|..|:.: :|.|:|     ..|:::|..:.:|.::|.|:|  .::.|.|.|.:||:.|
Human   221 -LVLGLLLTEIVRS-WSLALTWALNYRTGVRLRGAILTMAFKKILKL--KNIKEKSLGELINICS 281

  Fly   195 NDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEI--GIAAVFGMTFILLFIPLQMYLGKKISGLR 257
            ||..||.........|...|:.|::  .::|..|  |.....|....:||.|..|:..:..:..|
Human   282 NDGQRMFEAAAVGSLLAGGPVVAIL--GMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFR 344

  Fly   258 LKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFL 322
            .|....:|:|::.|.|::..|:.||||||...|.:.|...|.:|...:....|.:    |....:
Human   345 RKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQ----SITVGV 405

  Fly   323 TPVSIFL-SLVGF---VLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVT-----QTAETLVSI 378
            .|:.:.: |:|.|   :.:|..|||..||.:...:|    :||  |::.||     ..:|..|::
Human   406 APIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFN----SMT--FALKVTPFSVKSLSEASVAV 464

  Fly   379 KRVQKLLLSGEV---------------------------------------VAKDENVVSNGAEE 404
            .|.:.|.|..||                                       :.||:. .|.|.:|
Human   465 DRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKR-ASRGKKE 528

  Fly   405 D------------LQEAREKLLVTPTPMRAPEKPPHNSED--CVSISELKAKWTTNSPDYTLSGV 455
            .            |.|.:..||     :.:.|:|....|:  .:.:..|:.:       .||..:
Human   529 KVRQLQRTEHQAVLAEQKGHLL-----LDSDERPSPEEEEGKHIHLGHLRLQ-------RTLHSI 581

  Fly   456 NLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFG 520
            :|::..|.||.|.|..||||:|||.||||::.:..|.|.::|:.:|.:|:.|:.:.|:|.|||||
Human   582 DLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFG 646

  Fly   521 QPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDP 585
            :..|..||:.|:..|.|..|..:||..|.|.:|:|||:|||||:.||||||::|.|.|||:||||
Human   647 KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDP 711

  Fly   586 LSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLD 650
            |||:|:.|...:|...:|.||:.|.|:.||||||:|...|:::.|:.|.:...||:|.|.....|
Human   712 LSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGD 776

  Fly   651 FGIVLDD-PVNDNEAAEDRSRTSSITDQRRSSVK-----SVLSHAESCPEDVGEEQKINLQRQQL 709
            :..:.:: .:.:....|..|:..:...|::|..|     ||.......||   |.|.:.|:.:..
Human   777 YATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPE---EGQLVQLEEKGQ 838

  Fly   710 GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWV---SRNEKMVAHNYTT--- 768
            |.....||..|.:|.||.|:|.|:|..|:.:.|..:...::||.|:   |.|..:...|.|:
Human   839 GSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSD 903

  Fly   769 DAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPA 833
            ..||.....:.|.||.|...:.:::...|..:|....:|||.:||:.:||.|.|:.|.||:..|.
Human   904 SMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPT 968

  Fly   834 GSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLI---PALAFGIVIYYLRS 895
            |.|||||||||.:||..||......||:.:|....:.:||.|.|.||:   |.:....|::.:..
Human   969 GRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSR 1033

  Fly   896 FYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTS 960
            ..::   ::|||:..|:||..||..:|:.||:||.|:..|......:....|.:.:..::|....
Human  1034 VLIR---ELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAM 1095

  Fly   961 RAFAYWMDIFCVLFIA----MITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTM 1021
            |..|..:|:..:..|.    ||.|.....||:.|   ||||:.|:.|||..|:|||.::|.|...
Human  1096 RWLAVRLDLISIALITTTGLMIVLMHGQIPPAYA---GLAISYAVQLTGLFQFTVRLASETEARF 1157

  Fly  1022 ISVERMIEY-EEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKP 1085
            .||||:..| :.:..|.|.. ..:|.|...||::|::.|....:||...|  ..|||.:||.|||
Human  1158 TSVERINHYIKTLSLEAPAR-IKNKAPSPDWPQEGEVTFENAEMRYRENL--PLVLKKVSFTIKP 1219

  Fly  1086 KEKVGIVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTV 1149
            |||:|||||||:|||||..||||| ..:.|.::||....:|:||.|||||:||||||||||||||
Human  1220 KEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTV 1284

  Fly  1150 RHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNR 1214
            |.|||||::|::|::|.|||...:|:.:|.:...||:::.|.|.|||||:|||:|:|||:||..:
Human  1285 RSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCK 1349

  Fly  1215 ILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYEL 1279
            ||::|||||.:|.:||.|||.|||..|.:||:||:||||||::.|||::|:..|:||||.||..|
Human  1350 ILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVL 1414

  Fly  1280 LTADDTNAF 1288
            |:.|.:..:
Human  1415 LSNDSSRFY 1423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_724148.2	PLN03130	7..1313	CDD:215595	474/1374 (34%)
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	474/1372 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		5/37 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		8/35 (23%)