DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31792 and ABCC5

DIOPT Version :9

Sequence 1:NP_001260548.1 Gene:CG31792 / 35163 FlyBaseID:FBgn0051792 Length:1323 Species:Drosophila melanogaster
Sequence 2:NP_005679.2 Gene:ABCC5 / 10057 HGNCID:56 Length:1437 Species:Homo sapiens


Alignment Length:1369 Identity:472/1369 - (34%)
Similarity:735/1369 - (53%) Gaps:134/1369 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ENPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESLG-NKLCSSWANEL-ETN 72
            ::|.:.:.:||.::| |.:....:..:|..|..:|:: :|.:|.:..:. .:|...|..|| |..
Human    98 QHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEELNEVG 161

  Fly    73 KKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTV---QPMFLMKLISSFSNPSPTSNGVAYAYAG 134
            ...|||.||:: :|.|..:.|.:|  ||.:....   .|.|::|.:..::  ..|.:.:.|:.. 
Human   162 PDAASLRRVVW-IFCRTRLILSIV--CLMITQLAGFSGPAFMVKHLLEYT--QATESNLQYSLL- 220

  Fly   135 GVILGSALKVILMNPYSFAVT-----HLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLIS 194
             ::||..|..|:.: :|.|:|     ..|:::|..:.:|.::|.|:|  .::.|.|.|.:||:.|
Human   221 -LVLGLLLTEIVRS-WSLALTWALNYRTGVRLRGAILTMAFKKILKL--KNIKEKSLGELINICS 281

  Fly   195 NDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEI--GIAAVFGMTFILLFIPLQMYLGKKISGLR 257
            ||..||.........|...|:.|::  .::|..|  |.....|....:||.|..|:..:..:..|
Human   282 NDGQRMFEAAAVGSLLAGGPVVAIL--GMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFR 344

  Fly   258 LKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSFNRFL 322
            .|....:|:|::.|.|::..|:.||||||...|.:.|...|.:|...:....|.:    |....:
Human   345 RKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQ----SITVGV 405

  Fly   323 TPVSIFL-SLVGF---VLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVT-----QTAETLVSI 378
            .|:.:.: |:|.|   :.:|..|||..||.:...:|    :||  |::.||     ..:|..|::
Human   406 APIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFN----SMT--FALKVTPFSVKSLSEASVAV 464

  Fly   379 KRVQKLLLSGEV---------------------------------------VAKDENVVSNGAEE 404
            .|.:.|.|..||                                       :.||:. .|.|.:|
Human   465 DRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKR-ASRGKKE 528

  Fly   405 ---DLQEAREKLLVTPTP----MRAPEKPPHNSED--CVSISELKAKWTTNSPDYTLSGVNLQVH 460
               .||....:.::....    :.:.|:|....|:  .:.:..|:.:       .||..::|::.
Human   529 KVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQ-------RTLHSIDLEIQ 586

  Fly   461 AGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDR 525
            .|.||.|.|..||||:|||.||||::.:..|.|.::|:.:|.:|:.|:.:.|:|.|||||:..|.
Human   587 EGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDE 651

  Fly   526 RRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVD 590
            .||:.|:..|.|..|..:||..|.|.:|:|||:|||||:.||||||::|.|.|||:|||||||:|
Human   652 ERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALD 716

  Fly   591 SSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVL 655
            :.|...:|...:|.||:.|.|:.||||||:|...|:::.|:.|.:...||:|.|.....|:..:.
Human   717 AHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIF 781

  Fly   656 DD-PVNDNEAAEDRSRTSSITDQRRSSVK-----SVLSHAESCPEDVGEEQKINLQRQQLGRNGL 714
            :: .:.:....|..|:..:...|::|..|     ||.......||   |.|.:.|:.:..|....
Human   782 NNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPE---EGQLVQLEEKGQGSVPW 843

  Fly   715 GVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWV---SRNEKMVAHNYTT---DAKDA 773
            .||..|.:|.||.|:|.|:|..|:.:.|..:...::||.|:   |.|..:...|.|:   ..||.
Human   844 SVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDN 908

  Fly   774 DFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILN 838
            ....:.|.||.|...:.:::...|..:|....:|||.:||:.:||.|.|:.|.||:..|.|.|||
Human   909 PHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILN 973

  Fly   839 RFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLFLI---PALAFGIVIYYLRSFYLKT 900
            ||||||.:||..||......||:.:|....:.:||.|.|.||:   |.:....|::.:....:: 
Human   974 RFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIR- 1037

  Fly   901 SLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAY 965
              ::|||:..|:||..||..:|:.||:||.|:..|......:....|.:.:..::|....|..|.
Human  1038 --ELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAV 1100

  Fly   966 WMDIFCVLFIA----MITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVER 1026
            .:|:..:..|.    ||.|.....||:.|   ||||:.|:.|||..|:|||.::|.|....||||
Human  1101 RLDLISIALITTTGLMIVLMHGQIPPAYA---GLAISYAVQLTGLFQFTVRLASETEARFTSVER 1162

  Fly  1027 MIEY-EEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVG 1090
            :..| :.:..|.|.. ..:|.|...||::|::.|....:||...|  ..|||.:||.||||||:|
Human  1163 INHYIKTLSLEAPAR-IKNKAPSPDWPQEGEVTFENAEMRYRENL--PLVLKKVSFTIKPKEKIG 1224

  Fly  1091 IVGRTGAGKSSLINALFRL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLD 1154
            ||||||:|||||..||||| ..:.|.::||....:|:||.|||||:|||||||||||||||.|||
Human  1225 IVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLD 1289

  Fly  1155 PFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMD 1219
            ||::|::|::|.|||...:|:.:|.:...||:::.|.|.|||||:|||:|:|||:||..:||::|
Human  1290 PFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILD 1354

  Fly  1220 EATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADD 1284
            ||||.:|.:||.|||.|||..|.:||:||:||||||::.|||::|:..|:||||.||..||:.|.
Human  1355 EATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS 1419

  Fly  1285 TNAF 1288
            :..:
Human  1420 SRFY 1423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31792NP_001260548.1 CFTR_protein 12..1281 CDD:273530 470/1359 (35%)
ABC_membrane 94..360 CDD:294371 72/279 (26%)
ABCC_MRP_domain1 434..634 CDD:213217 88/199 (44%)
ABC_membrane 736..980 CDD:294371 78/256 (30%)
ABCC_MRP_domain2 1055..1276 CDD:213211 126/221 (57%)
ABCC5NP_005679.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..41
CFTR_protein 100..1430 CDD:273530 472/1367 (35%)
ABC_membrane <271..447 CDD:294371 53/187 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..538 7/37 (19%)
ABCC_MRP_domain1 577..759 CDD:213217 87/181 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..827 8/35 (23%)
ABC_membrane 863..1143 CDD:294371 91/285 (32%)
ABCC_MRP_domain2 1191..1411 CDD:213211 126/221 (57%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151526
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1827
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.610

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