DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc2

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_004915926.1	Gene:	abcc2 / 100485020	XenbaseID:	XB-GENE-1012796	Length:	1552	Species:	Xenopus tropicalis

Alignment Length:	1416	Identity:	477/1416 - (33%)
Similarity:	737/1416 - (52%)	Gaps:	170/1416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SFKNEDLPENPRERSNIFSALSF-WYTIPTFIKGQKVTLGAKDLYRALKEHRAESL--------- 57
            |.|||...|||...::..|.::| ||. ...:||.|..|..:||:...:|.:.:::
Frog   193 SEKNESTKENPELTASFLSRITFNWYN-SIVVKGYKKPLEMEDLWELNEEDKTKNMYEIFEKHMK 256

  Fly    58 -------------------------GNKLCSSWANEL--------ETNKKNAS------------ 77
                                     .|.:..:.:.::        |..||..|
Frog   257 HDVRKAKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRW 321

  Fly    78 LLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSNGVAYAYAGGVILGSAL 142
            |::.|.:.|....:...:.....:::..|.|..|..:::..::|| ......:.||..:::.:.|
Frog   322 LIKTLIKTFPSTLLTSAIFKLLHDLLAFVSPQILKVMVTFTADPS-QHQWQGFFYAVLLLVTALL 385

  Fly   143 KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFT 207
            :..|:..|......||:::|..:.:.:|:|.|.::.....|.:.|..:||:|.|..|......|.
Frog   386 QSFLLQQYFHGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLTNFI 450

  Fly   208 HYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMT 272
            |.||.:|||..:....:::|:|.:.:.|:..::|.||:...|......|::|.....||||:||.
Frog   451 HLLWSSPLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKRMKIMN 515

  Fly   273 EIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAY---AKCLIWSFNRFLTPVSIFLSLVGF 334
            ||:.||:::|:||||..||..|...|.||:..:.|..|   ....:::...||..|:.|...|.
Frog   516 EILNGIKILKLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTCAPFLVSVATFAVYVA- 579

  Fly   335 VLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQKLL----LSGEVVAKDE 395
            |.....|.||.||...:.:|::|..: |...:.::...:|.||..|::|.|    |....:..|.
Frog   580 VDPSNVLNAEKAFTSISLFNILRFPL-AMLPMLISSMVQTSVSSARLEKYLGGDNLDTSAIRCDP 643

  Fly   396 NVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVH 460
            |:                                 :..|..|:....|..:: :..::.|||.:.
Frog   644 NI---------------------------------DAAVQFSDATFSWEEDA-NPAVNNVNLDIK 674

  Fly   461 AGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDR 525
            .|.|||:||..|||||||:.|:|||:....|.|.:.||::|..|:.|:.:.|::.|||||..||.
Frog   675 EGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILFGSKMDE 739

  Fly   526 RRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVD 590
            .||..|:..|||..|.|:||..|::.:|::|.:||||||.|:||||:||.||.||:|||||||||
Frog   740 ERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDDPLSAVD 804

  Fly   591 SSVARRLFEECL--RGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGI 653
            :.|.:.:||:.:  .|.|::|..|||||.:.||:.||.||::...:|...|:|::|..:...|..
Frog   805 AHVGKHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQANNGAFAE 869

  Fly   654 VL-----DDPVNDNEAA--------------------ED--------------RSRTS-SITDQR 678
            .|     .:...||||.                    ||              |.|:| |:....
Frog   870 FLRLYAKQNDQTDNEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSMRQRKRSSVSMNGTL 934

  Fly   679 RSSVKSVLSHAESCPEDVGEEQK-INLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQG 742
            |.|||.|.........:..:.|| |..:..:.|:....:|:.|.||.|...||.:.:::.:  |.
Frog   935 RRSVKDVTKKKTGIGSNDTKGQKLIEKETVETGKVKFKLYLKYLRAVGWGFSFWIFVSYIL--QN 997

  Fly   743 LASLG-DYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAM 806
            .|.:| :.:||.|....||.  :|.|..|...|..:.   ::..:.|...:..:..:||....|:
Frog   998 AAFVGQNIWLSDWTGDAEKY--YNITYPASQRDMRVG---VFGALGVAQALFVLLGAFLVSGGAV 1057

  Fly   807 RASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIV 871
            |||..||..:...|.|..|.||:..|.|.|:|||:||:..|||.:|....:.|..||...|.:.:
Frog  1058 RASRMLHTQLLHNILRVPMRFFDTTPTGRIVNRFAKDILTVDETIPMSFRSWIACFLGVIGTLFI 1122

  Fly   872 IAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGS 936
            |.:..|:|....:...|..|:::.||:.||..::||::.||||:||||..:::|||.|||:|...
Frog  1123 ICLATPIFAAVIVPLAIFYYFVQRFYVTTSRQLRRLDSVTRSPIYSHFGETVSGLSVIRAYGHQD 1187

  Fly   937 ILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSF---FIFPPSSAAD---VGL 995
            ......:...|.:..:.|.:|.::|..|..::     |:..:|:.|   |........|   |||
Frog  1188 RFLQHNEDTIDNNQKSVYSWIVSNRWLAIRLE-----FVGNLTVFFAALFAVLGRGTVDSGTVGL 1247

  Fly   996 AITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFV 1060
            :|:.|:.:|.|:.|.||.::|||..:::|||:.||.::|.|.  :...|.:|.:.|||:|.::||
Frog  1248 SISSALNITQTLNWLVRMTSELETNIVAVERVDEYIKVEREA--QWVEDHRPPKDWPEKGVVQFV 1310

  Fly  1061 ELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYN-DGSVRIDDKDTN 1124
            :..:||.|.|  :.||:.:|..|...||||||||||||||||.|.:||:..: .|.:.||..|..
Frog  1311 DYKVRYRPEL--DLVLQGISCTINSMEKVGIVGRTGAGKSSLTNCIFRIIESAGGKIMIDGLDIA 1373

  Fly  1125 DMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKIT 1189
            .:||||||.|::||||:||||||.:|.|||||::|:|:.:|.|||...||..|..:...|..:::
Frog  1374 SIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPFNQYTDEDIWKALELSHLKPFVEGLQEKLFHEVS 1438

  Fly  1190 EGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLH 1254
            |||.|.|||||||||||||:||.::||::|||||.||.:||.|||.|||::|.:|||||:|||||
Frog  1439 EGGENLSVGQRQLVCLARALLRKSKILILDEATAAVDLETDNLIQRTIRSEFADCTVLTIAHRLH 1503

  Fly  1255 TIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTG-QATYDTLL 1304
            |||||.|::|:|||:::|||:|.|||...  ..|..:.|..| .:|..|:|
Frog  1504 TIMDSSRLMVLDAGKIIEFGSPDELLQRQ--GHFFSMAKDAGIDSTQSTIL 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	465/1381 (34%)
		ABC_membrane	94..360	CDD:294371	75/268 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	94/201 (47%)
		ABC_membrane	736..980	CDD:294371	74/244 (30%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	127/221 (57%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	473/1406 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930