DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc8b

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1419	Identity:	428/1419 - (30%)
Similarity:	706/1419 - (49%)	Gaps:	202/1419 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSALSFWYTIPTFI-KGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANELETN----KKNAS 77
            |:.|..::|: :.||| ...:..:..|.:.:..|..||.|...:|..::.:::|:.    :.:..
Zfish   238 NLLSKSTYWW-MNTFITSAHQRPIDLKTIGKLPKSMRALSNFQQLRKAFDSQMESGCVHLQGSGW 301

  Fly    78 LLRVLFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPSPTSN------GV-------- 128
            :.|.|.:.||...:......|..:::....|:.:..::...|..:.|:.      ||
Zfish   302 MWRALRQAFGAPLLLSICFRFISDLLGFAGPLCISGILQHISRDNHTAPPPVKLLGVHFISSEVF 366

  Fly   129 -AYAYAGGVILGSAL---KVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRL--TKTDLGEISTG 187
             |.||...|:|..||   :..|...|..|:.: |:.:|..|.:.||.|.:||  :...:|:::|.
Zfish   367 FANAYVLAVLLFLALLLQRTFLQASYYVAIEN-GINLRGAVQTKIYNKIMRLCTSNMSMGDMTTA 430

  Fly   188 HIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKK 252
            .|.||::.|..::..|......||..|:|.::...|:|..:|.:|:.|.|.|.:..|||.::..:
Zfish   431 QICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLLGASALIGATVITVLAPLQYFVATR 495

  Fly   253 ISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWS 317
            :|..:..|...:.:|::...|::.||:::|:||||..|...|...|.:|:.|:|..|    |..|
Zfish   496 LSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSSVEETRRQELTSLRTFA----LYTS 556

  Fly   318 FNRFLT---PVSIFLSLVGFVLMGRF-------LTAEVAFLITAYYNVVRTNMTAYFSVGVTQTA 372
            .:.|:.   |::..|::  ||:....       |:..|||...:.::::.|.:....|| :..|.
Zfish   557 LSIFMNAAIPIAAVLTI--FVVHVHLQSSSDFALSPAVAFGSLSLFHILVTPLFLLSSV-LHSTV 618

  Fly   373 ETLVSIKRVQKLLLSGEVVAKDE-----------NVVS--------------NGAEEDLQEAREK 412
            :.|||::::.:.|.|.|:....:           |:.|              |.|::|:....|:
Zfish   619 KALVSVQKLSEFLSSAEIETDQDPIAQTPANNNGNIKSVYALQLQAKLVNRKNKAKQDVNRNFEQ 683

  Fly   413 LLVTPTPMRAPEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSS 477
               ....:||..:  |....|:.|......||...|  ||:.::::|..|.|..|||..||||||
Zfish   684 ---QDQELRASAQ--HEDNICIKIVNGYFSWTQGCP--TLTNIDIKVPFGQLTMIVGQVGSGKSS 741

  Fly   478 LIQAILGELRVESGEIEVT-------------------------GSMSYASQEPWLFSGTVRQNI 517
            |:.|.|||::..||.|...                         ||::||||.|||.:.||.:||
Zfish   742 LLLAALGEMQKISGSITWNSLPRSDSDENIRAHDMSGRQSFTRRGSVAYASQRPWLLNATVEENI 806

  Fly   518 LFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDR----GASLSGGQKARISLARSVYRDAS 578
            ||....:.:||..|:..|.|..|.:.||..|:|::|:|    |..|||||:.|||:||::|:..:
Zfish   807 LFDTAPNVKRYKDVIEVCQLGPDIDTLPQGDQTVIGERVRHLGIILSGGQRQRISVARALYQQTN 871

  Fly   579 IYLLDDPLSAVDSSVARRLFEECLRGHLRD--KIVILVTHQLQFLQQADQIVIMEMGKVKAVGTY 641
            :..||||.||:|..::..|..|.:...||.  :.|:||||:||:|..||.|:.|..|.|:..||
Zfish   872 VVFLDDPFSALDIHLSDHLMHEGILKFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGTVQTQGT- 935

  Fly   642 ESLHKSGLDFGIVLDDPVNDNEAAE-----------DRSRTSSITDQRRSSVKSVLSHAESCPED 695
                             :.|.:.||           :|....:.|:.:|.|.:..:.::......
Zfish   936 -----------------LKDIQCAEPELFEQWRTLMNRQDKENSTELKRKSFRRAMMYSRDTVAT 983

  Fly   696 VGEEQKINLQRQQL-------GRNGLGV------------YVDYFRAGGGFLSFSVVMTFFVCSQ 741
            ..|::..::...::       ..:.||.            :..|.:|.|.||     :...:.||
Zfish   984 DDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFATYLKAAGLFL-----LPLLIVSQ 1043

  Fly   742 ----GLASLGDYFLSPWVS-----RNEKMVAHNYTTDAKDADFEMHAAY--IYMLITVLSIMVTI 795
                .|....|::|:.|.|     ::|.  |....|..||..|. |:.|  ::.|:..|.|::.:
Zfish  1044 LAKHSLMVAIDFWLAHWTSDVIAAQSES--AERNCTFTKDCVFS-HSWYLQVFCLLCALGIVLCL 1105

  Fly   796 KRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQ 860
            ..|.......:|.:.:||.|:.|.|..|.|..|...|.|:||||||.|...:|:.:|..:..:.:
Zfish  1106 VTSLAVEWTGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILNRFSTDTNTIDQHIPVTMECLSR 1170

  Fly   861 DFLLFGGNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNG 925
            ..||....:.||:.|.|:|||..|...:..|:::.::...|.|:::||.||..|:.||::.::.|
Zfish  1171 STLLCVSAVGVISYVTPVFLIALLPLTVACYFIQKYFRVASRDLQQLEDSTEMPLLSHYSQTIEG 1235

  Fly   926 LSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI-------FCVLFIAMITLSFF 983
            |:|||||......:.:...:.|.::.:|....:.:|    |:::       ..||..|:.:::..
Zfish  1236 LTTIRAFRHEQRFKKKLLEHTDANNISSLFLTAANR----WLEVRMEYIGALVVLIAAVASITNA 1296

  Fly   984 IFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEG------PLEAT 1042
            ::...||..|||.:|.|:.::..:.|.||..|::|..:..|:|:......:||.      |.:..
Zfish  1297 LYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKRVSGLIHTQPESYDNIMTPAQVP 1361

  Fly  1043 ADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALF 1107
            |      .||:.|:|:...||:||:..||  .|||.:|..|:|.:||||.||||:||||...|||
Zfish  1362 A------GWPKYGEIQIQNLSVRYDSSLK--PVLKHVSAHIRPGQKVGICGRTGSGKSSFSLALF 1418

  Fly  1108 RL-SYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEEV 1171
            |: ...:|.:.||..|.:.:.|..||||.|||.|:|:|||||:|.||||..:.:|:.||.|||..
Zfish  1419 RMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDPERKATDEMLWEALEIA 1483

  Fly  1172 ELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQAT 1236
            :|..||.::..||:..:||||.|||.|||||.|||||.:|.:.||:||||||::|..|::::|..
Zfish  1484 QLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDEATASIDMATESILQKV 1548

  Fly  1237 IRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDT--NAF 1288
            :...|.:.||:|:|||:|||:.||.|:||..|.::|:..|..||...|:  :||
Zfish  1549 VMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLLEQKDSVFSAF 1602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	424/1408 (30%)
		ABC_membrane	94..360	CDD:294371	75/295 (25%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/230 (38%)
		ABC_membrane	736..980	CDD:294371	73/261 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	111/221 (50%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	425/1414 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650