DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	NP_001135594.1	Gene:	abcc10 / 100216149	XenbaseID:	XB-GENE-6465377	Length:	1501	Species:	Xenopus tropicalis

Alignment Length:	1292	Identity:	437/1292 - (33%)
Similarity:	683/1292 - (52%)	Gaps:	146/1292 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NKKNASLLRV---LFRVFGRYFVFLGLVLFCLEVILTVQPMFLMKLISSFSNPS--PTSNGVAYA 131
            :|.::::||:   |...||..:..|||:......:..:.|: |:.|:.:|...:  |.|.|:.|.
Frog   275 SKSSSTILRLLPTLHASFGARYYALGLLKLGAVTLAFLGPL-LLNLLVNFMEAADEPLSWGILYT 338

  Fly   132 YAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGHIINLISND 196
            .  |:.....|..:|.|.::..|..|.|.:|..|.:.:|||.:|...|.|...|.|.|:|.:|.|
Frog   339 L--GLFSSCFLAALLQNQFTHEVNKLILAVRASVLTSVYRKAIRGVGTGLAGFSKGEIVNFMSTD 401

  Fly   197 LGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKISGLRLKTA 261
            ..|:..|.:..|.:|..|||..:..||:|.::|||.:.|:...:|.:|:...:..:|........
Frog   402 ADRISNFCRSFHEVWSLPLQFSVTLYLLYLQVGIAFLGGLGLAVLLLPINKVIANRIVDYNSDLL 466

  Fly   262 IRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAY--AKCL-IWSFNRFLT 323
            ...|.|:::|||:::|::|:|.|.||..|.:.|...|.||:.|:|.:..  |.|: :|:    ..
Frog   467 NHKDARVKLMTELLSGMRVVKFYTWEKHFAEAVTSLREKELRSLRALKMLDAVCVYLWA----AL 527

  Fly   324 PVSI-FLSLVGFVLMGRFLTAEVAFLITAYYN--VVRTNMTAYFSVGVTQTAETLVSIKRVQKLL 385
            ||.| .::.:.:||:|..|||...|...|...  ::..|...:...||   .|..||::|:|..:
Frog   528 PVLISIITFITYVLLGHQLTAAKVFTALALVGMLILPLNNFPWVLNGV---LEAKVSLERIQLFM 589

  Fly   386 LSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPEKPPHNSEDCVSISELKAKW----TTN 446
                          :..|:||.....            ::||.:....:.:......|    :.:
Frog   590 --------------DLPEQDLLNYYS------------QEPPADPSSALELRSAAFSWMPEESED 628

  Fly   447 SPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTG---SMSYASQEPWL 508
            |....|...:|.|..|.||.:||..|.|||||:.|:.|||....||:..:.   ...:|:||||:
Frog   629 SGSLQLFIEHLSVQKGVLVGVVGKVGCGKSSLLAALTGELSRSGGELFASHQELGFGFAAQEPWI 693

  Fly   509 FSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISLARSV 573
            ...|:|:|||||:..:.:.|..|:..|||..|..:||..|:|.:|:.|.:||||||||::|||:|
Frog   694 QFATIRENILFGKEFNGKLYQGVLEACALNDDLSILPSGDQTEVGENGVTLSGGQKARLALARAV 758

  Fly   574 YRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGKVKAV 638
            |:|..||||||||:|||:.||..|.|:|:.|.|::|..||.||:.:.|.:||.:::||.||:...
Frog   759 YQDKDIYLLDDPLAAVDADVAAHLMEKCILGILKNKTRILCTHRTELLDKADIVLLMEGGKMVGS 823

  Fly   639 GTYESLHKSGLDFGIVLDDPV---NDNEAAEDRSRTSSITDQRRSSVKSVLSHAES-------CP 693
            ||.:.:.            |:   :.|..:..:::.:.|:.....|::.....||:       ..
Frog   824 GTPDKIL------------PLVESSRNRGSRGQTQMNHISQAAEQSLEEDEEEAENEGNPIQPIT 876

  Fly   694 EDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSRN 758
            .:||:|:|      |.|...|.||..|::|.||.|:.||::..|: .|...::.|::||.|:|..
Frog   877 AEVGQEEK------QEGAVALQVYWAYWKAVGGCLAGSVLLALFL-MQASRNISDWWLSHWISSL 934

  Fly   759 EKMVAHNYTTDAKDADF------------------EMHAA------------YIYMLITVLSIMV 793
            :....:...|:...:.|                  .:|:|            .:|..|.|.:.:.
Frog   935 QDSPRNVSLTNLTPSSFPSASLLLFSQGGLVSPISSVHSAEKNSSLDITFYLSVYGGIAVANSIF 999

  Fly   794 TIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTV 858
            |..|:|||....:.|::.:|..:...:.:|::.||:..|.|.|:||||.|:..||:.||    .|
Frog  1000 TALRAFLFALGTVHAAVVIHRRLLSSVLQATVSFFDSTPIGRIINRFSSDLYCVDDSLP----FV 1060

  Fly   859 IQDFLLFG----GNIIVIAIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHF 919
            :..||.|.    |.:::|:...|..|...|...::.|||:.||..:|.::|||::.|.||:|:||
Frog  1061 LNIFLAFTFGLLGMLVMISYGLPWILPVLLPLCLLYYYLQRFYRHSSRELKRLQSITLSPIYTHF 1125

  Fly   920 AASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDI----FCVLFIAMITL 980
            :.:|.||:||||.......|||.....:::....:    .|.|...|:||    ..|:.:|.|::
Frog  1126 SETLTGLTTIRATRHADRFEAECVSRLEVNQRCMF----ASNAAVQWLDIRLQMIGVMVVAAISV 1186

  Fly   981 SFFIFPPSSAAD---VGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEP----EGP 1038
            ...|.....:.|   ||||::.|:.:||.:...:....:.|..|:||||..||....|    ||.
Frog  1187 IAIIQHQRKSGDPGLVGLALSYALSITGILSGLISSFTQTEAMMVSVERTEEYSTTLPSESAEGS 1251

  Fly  1039 LEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLI 1103
            |:...|      ||..|.|||..:.|.|.  |...:.|..:||.|.|.||:|||||||:|||:|.
Frog  1252 LQVELD------WPTNGHIEFRNVVLCYR--LGLPNALDGISFTISPGEKIGIVGRTGSGKSTLF 1308

  Fly  1104 NALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCA 1167
            .|||| :...:||:.||:..::.:.|..|||:::||||:..||||:||.||||...::|..:...
Frog  1309 LALFRMMELKEGSILIDNVPSHLLNLELLRSRLAIIPQDAFLFSGSVRVNLDPLSYHTDVEILKV 1373

  Fly  1168 LEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDAL 1232
            |::..|:|||..:. ||:..:.:.|.|||:|||||:|||||:|...:||.:|||||:||.|||.|
Frog  1374 LDQCHLQDVVRRIG-GLDADVGDRGKNFSLGQRQLLCLARALLTHAKILCIDEATASVDHQTDEL 1437

  Fly  1233 IQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQ 1289
            :|.|||.:|||.||||:||||:|||||||||||.||::||..:|..|...:|:|.::
Frog  1438 LQRTIRERFRERTVLTIAHRLNTIMDSDRVLVMHAGKLVELDSPANLSKREDSNFYR 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	435/1282 (34%)
		ABC_membrane	94..360	CDD:294371	80/273 (29%)
		ABCC_MRP_domain1	434..634	CDD:213217	88/206 (43%)
		ABC_membrane	736..980	CDD:294371	78/281 (28%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	117/221 (53%)
abcc10	NP_001135594.1	MRP_assoc_pro	180..1484	CDD:188098	434/1280 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920