DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31792 and abcb10

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	716	Identity:	180/716 - (25%)
Similarity:	300/716 - (41%)	Gaps:	173/716 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 DRSRTSSITDQRRSSVKSVLSHAESCP---EDVGEEQKINLQRQQLGRNGLGVYVDYFRAGGGFL 728
            |.::||.....:.||.|:.   |:|.|   |||  ::.:.|...|..|         ..|..|||
Zfish    92 DSNQTSKSVVNQESSAKTT---ADSLPVPSEDV--KKLLQLAHPQRWR---------LTAAVGFL 142

  Fly   729 SFSVVMTFFVCSQGLASLGDYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYMLITVLSIMV 793
            ..|..:|.         ...:||.       |::...||:..:|....         :|.|.:|:
Zfish   143 VISSTVTM---------SAPFFLG-------KVIDTIYTSPTEDFSSS---------LTSLCLML 182

  Fly   794 TIKRSFLFFNLAMRASI------------QLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQ 846
            |  ..||....|..|.:            :|..|:|..|.:..:.||:|...|.::||.|.|...
Zfish   183 T--GVFLCGGAANAARVYLMQISGQQIVRKLRESLFSSILKQELGFFDKTRTGELINRLSADTAI 245

  Fly   847 VDEMLPTIIMTVIQDFLLFGGNIIVIAIVNP------LFLIPALAFGIVIY--YLRSFYLKTSLD 903
            |...|...:...::.....|..:.::..|:|      |.::|.:|...||:  :|||...:|.
Zfish   246 VGRCLTDNLSDGLRSLAQAGAGVGMMLYVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQ-- 308

  Fly   904 VKRLEASTRSPVYSHFAASLNGLSTIRAFG---------------------AGSILEAEFDGYQD 947
             ..|..:|:..     ...::.|.|:||||                     ..:::.|.|.|...
Zfish   309 -DALAEATQLA-----EERISNLRTVRAFGKELTEVQKYSQKVDHIFELAKKEAVVSAGFYGVTG 367

  Fly   948 MHSSA---SYMF---------------ISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVG 994
            :..:.   |.::               :|:...:|:|:.|....|     .||:
Zfish   368 LSGNVIILSVLYKGGLLMASEAMTVGQLSSFLMYAFWVGISIAGF-----SSFY----------- 416

  Fly   995 LAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLE----ATADKKPHESWPEQG 1055
            ..:.:.:| .||..|.:            ::|       :||.||.    .|::..       :|
Zfish   417 SELMKGLG-AGTRLWEL------------IDR-------KPEFPLNEGLVLTSELL-------KG 454

  Fly  1056 KIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYND-GSVRID 1119
            ::||..:|..| |..|...:.:.||..:.....:.:||.:|:|||||::.|.||...| |.|.:|
Zfish   455 ELEFRNVSFAY-PTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVSLLLRLYDPDSGIVSVD 518

  Fly  1120 DKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNL-----DPFDEYSDDRLWCALEEVELKDVVAS 1179
            ..|..|:..:.|||.|..:.|||||||.::..|:     ||.....:| ::.|.:.....|.:..
Zfish   519 GHDIRDLNPYWLRSHIGTVSQEPVLFSCSIAENIAYGAPDPSQVTVED-IYRAAQIANAHDFIQE 582

  Fly  1180 VATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQATIRNKFREC 1244
            ...|.:|.:.|.|...|.||:|.|.:|||:|::.:||::||||:.:|.:.:.|:|..:.......
Zfish   583 FPKGYDTVVGEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAENEFLVQEALERLMDGR 647

  Fly  1245 TVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQR 1309
            |||.:||||.||..:|.|.|:|..||:|.|:..:|| |:|...|:.|:::      ...|:..|:
Zfish   648 TVLIIAHRLSTIQSADSVAVLDQHRVMEIGSHSQLL-ANDQGLFRKLMEK------QAFLQAEQK 705

  Fly  1310 E 1310
            :
Zfish   706 Q 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	173/685 (25%)
		ABC_membrane	94..360	CDD:294371
		ABCC_MRP_domain1	434..634	CDD:213217
		ABC_membrane	736..980	CDD:294371	57/302 (19%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	82/226 (36%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	166/669 (25%)
		ABC_membrane	141..402	CDD:279056	57/295 (19%)
		P-loop_NTPase	457..697	CDD:304359	87/248 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000