DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc6b.2

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_003198194.2	Gene:	abcc6b.2 / 100002917	ZFINID:	ZDB-GENE-110208-2	Length:	1502	Species:	Danio rerio

Alignment Length:	1362	Identity:	465/1362 - (34%)
Similarity:	723/1362 - (53%)	Gaps:	154/1362 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWA----------- 66
            |.|.::..|.|.||:.....:||.:..|.|:||:...:|..:|.:...|...||
Zfish   207 PVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQQKKS 271

  Fly    67 --NELET-NKKNASLLRVLFR------------------VFGRYFVFLGLVLFCLEVILTVQPMF 110
              ||.:| ..|.:|.::.|||                  :|..||:...|.|...:.::...|..
Zfish   272 SLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQDALMFSIPQV 336

  Fly   111 LMKLISSF-SNPSPTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCL 174
            |..|:... ...:|...|  |.:|..:.|.|.|:.:..:.|.:....:|::::..|..::|||.|
Zfish   337 LSLLLGYVRDEDAPLWKG--YLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVYRKSL 399

  Fly   175 RLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFI 239
            .:........:.|.|:||:|.|..::..|:.:.:.|||||::..:..:.::|.:|.:.:.|:|.:
Zfish   400 VINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAGITTV 464

  Fly   240 LLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINS 304
            :|..||..::.|..|.|:.......|:|:::|.||::||:::|.||||..|.:.|...|.||:|:
Zfish   465 ILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREKELNA 529

  Fly   305 IR--HVAYAKCLIWSFNRFLTPVSIFLSLVGFVLMGRF--------LTAEVAFLITAYYNVVRTN 359
            ::  .:.|: ..|.|||....       |:.|.:.|.:        |.|:..|:..|..|:::..
Zfish   530 LKKSQILYS-VSIASFNSSTL-------LIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAP 586

  Fly   360 MTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRAPE 424
            : :...:.::.|.:.:||:||:      |..:.:||                  |...:..|.|.
Zfish   587 L-SQLPIAMSTTMQVVVSLKRL------GTFLDQDE------------------LKLDSVQRVPY 626

  Fly   425 KPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVE 489
            .|  |.|..| |:.....|:.:|.. .|..:|::|..|:|||:|||.|||||||:.|:|||:..:
Zfish   627 NP--NIESVV-INNGTFSWSKDSTP-CLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKK 687

  Fly   490 SGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGD 554
            ||.|.:|||:.|..|:.|:.:.|::.|||||.......|..|:..|||..|.|:||.:|.|.:|:
Zfish   688 SGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGE 752

  Fly   555 RGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVTHQ 617
            :|.:||||||.|:||||:|||::.||||||||||||:.|.:.:||:.:  .|.|::|..:||||.
Zfish   753 KGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHG 817

  Fly   618 LQFLQQADQIVIMEMGKVKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDRSRTS------SITD 676
            |.||.|||.|::|..|::|.:|:|..|......|..:....|::.:.:.....|.      ||.|
Zfish   818 LSFLPQADLILVMADGEIKEMGSYAELLSRKNAFAELKAFSVSERKESATLKGTRKSVSFLSIKD 882

  Fly   677 QRRSSVKSVLSHAESCPEDVGEEQKINLQRQQLGR--------NG---LGVYVDYFRAGGGFLSF 730
            .....::..|..|.....:...:.|:|..|.::||        .|   |.:||:|||..|  |:|
Zfish   883 FSTDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIG--LAF 945

  Fly   731 SVVMTFFVCSQGLASLG-DYFLSPWVSRNEKMVAHNYTTDAKDADFEMHAAYIYML-ITVLSIMV 793
            .:.:.|....|.:|||. :|:||.|.  ::.::  |.|....|....::.|..:.. |.:....|
Zfish   946 IIPIIFLYAFQQVASLAYNYWLSLWA--DDPVI--NGTQVNTDLKLGVYGALGFAQGIAIFGTTV 1006

  Fly   794 TIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLP---TII 855
            .|....:.      ||.|||..:...:..:.|.||...|:|::||||||::..:|.|:|   .|:
Zfish  1007 AISLGGII------ASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIM 1065

  Fly   856 MTVIQDFLLFGGNIIVI-------AIVNPLFLIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRS 913
            :..:  |.|....|||:       .|:.||.|:.|        :::|||:.||..::|||:.:||
Zfish  1066 LGYV--FKLLEVCIIVLMATPFAGVIILPLTLLYA--------FIQSFYVATSCQLRRLESVSRS 1120

  Fly   914 PVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSRAFAYWMDIF-CVLFIAM 977
            |:|:||..::.|.|.|||||.......:.:...|::.::.:.....||..|..::.. .:|.:|.
Zfish  1121 PIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAA 1185

  Fly   978 ITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELENTMISVERMIEYEEIEPEGPLEAT 1042
            ..||.......|...||||::.::.:||.:.|.||...::||.::||||:.||.|...|.|.  |
Zfish  1186 AILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPW--T 1248

  Fly  1043 ADKKPHES-WPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIKPKEKVGIVGRTGAGKSSLINAL 1106
            .:..|..| ||..|.|.|....|:|...|  :..||.:|..:..:||||||||||||||||...:
Zfish  1249 FEDSPLPSDWPRSGSIGFQAYGLQYRKGL--DWALKEISLSVNEREKVGIVGRTGAGKSSLALGI 1311

  Fly  1107 FR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGTVRHNLDPFDEYSDDRLWCALEE 1170
            || |....|.:.||..:..::|||:|||:|:||||:||||||::|.||||||.|:|:.:|.:||.
Zfish  1312 FRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLEL 1376

  Fly  1171 VELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDNRILVMDEATANVDPQTDALIQA 1235
            ..||..|:.:...|..:.:|||.|.|:|||||:|||||:||..:|||:|||||.||.:||.|||:
Zfish  1377 AHLKTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQS 1441

  Fly  1236 TIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYELLTADDTNAFQDLVKQTGQ 1297
            |||.:|.:|||||:||||:||||..||:|||.|.:.|..:|            .:|:.|.||
Zfish  1442 TIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSP------------SNLISQHGQ 1491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	461/1344 (34%)
		ABC_membrane	94..360	CDD:294371	72/276 (26%)
		ABCC_MRP_domain1	434..634	CDD:213217	97/201 (48%)
		ABC_membrane	736..980	CDD:294371	73/256 (29%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	120/221 (54%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	465/1362 (34%)
		ABC_membrane	320..587	CDD:294371	72/276 (26%)
		ABCC_MRP_domain1	633..834	CDD:213217	97/202 (48%)
		ABC_membrane	950..1215	CDD:279056	82/284 (29%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	120/221 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760